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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 5 | Sensitivity analysis of a fixed-bed gas-solid TSA: the problem of design with uncertain models 显示文摘 | Ratto M Lodi G Costa P | 1996 | Separations Technology1996，6，4： | 1 |
| 6 | Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde 显示文摘 | Costa S Coelho P Costa C | 2008 | Toxicology2008，252，13： | 1 |
| 7 | Acetylcholine as a mitogen:muscarinic receptor - mediated proliferation of rat astrocytes and human astrocytoma cells 显示文摘 | Costa P Peters J | 1996 | Eur Phamacol1996，297，： | 1 |
| 8 | The effects of niobium and nickel on the corrosion resistance of the zinc phosphate layers显示文摘 | Banczek E P Rodrigues P R P Costa I | 2008 | Surface and Coatings Technology2008，202，10： | 1 |
| 9 | Induction of cold hardiness by salt stress involves synthesis of cold and abscisic acid responsive proteins in Pmato显示文摘 | Ryu S tS Costa A Xin Z G Li P H | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 10 | Determination of triglycer- ides in human plasma using near-infrared spectroscopy and multivariate calibration methods 显示文摘 | da Costa Filho P A Poppi R J | 2001 | Analytica Chimica Acta2001，446，12： | 1 |
| 11 | Preliminary experimental and theoretical analysis of limit performance of molten carbonate fuel cells显示文摘 | Arato E Bosio B costa P | 2001 | Journal of Power Sources2001，102，： | 1 |
| 12 | Fatigue behaviour of AA6082 friction stir welds under variable loadings显示文摘 | COSTA J D FERREIRA J A M BORREGO L P | 2012 | In- ternational Journal of Fatigue2012，37，： | 1 |
| 13 | An Introduction to the Five-factor Model and its Applications 显示文摘 | McCrae R R Costa P T | 1992 | Journal of Personality1992，60，2： | 1 |
| 14 | Molecularcloning and characterization of a vacuolar classⅢperoxidaseinvolved in the metabolism of anticancer alkaloids in Catha-ranthus roseus显示文摘 | COSTA M M HILLIOU F DUARTE P | 2008 | Plant Physiology2008，146，2： | 1 |
| 15 | Ratio between positive lymph no- and total dissected axillaries lymph nodes as an independent prognostic factor for disease free survival in patients with breast caneer显示文摘 | Megale Costa L J Soares H P Gaspar H A | 2004 | Am J Clin Oncol2004，27，3： | 1 |
| 16 | Non-invasive ventilation in chronic obstructive pulmonary disease patients: helmet versus facial mask显示文摘 | Navalesi P Costa R Ceriana P | 2007 | Intensive Care Med2007，33，1： | 1 |
| 17 | New catalysts fordeep hydrotreatment of diesel fuel: Kinetics of 4,6-dimethyldibenzothiophenehydrodesulfurization over aluminasupportedmolybdenum carbide显示文摘 | Costa P Da Potvin C Manoli J M | 2002 | Journal of MolecularCatalysis A: Chemistry2002，184，12： | 1 |
| 18 | Video-nystagmography findings in healthy elderly subjects显示文摘 | Amor Dorado J C Rubio Rodríguez J P Costa Ribas C | 2003 | Acta Otorrinolaringol Esp2003，54，3： | 1 |
| 19 | Can the integration\sof multiple biomarkers and sediment geochemistry aidsolving the complexity of sediment risk assessment?Acase study with a benthic fish显示文摘 | Costa P M Caeiro S Vale C | 2012 | Environmental Pollution2012，161，0： | 1 |
| 20 | Connectivity between estuaries and marine environment:Integrating metrics to assess estuarine nursery function显示文摘 | VASCONCELOS R P REIS-SANTOS P COSTA M J | 2011 | Ecological Indicators2011，11，5： | 1 |
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