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| 1 | Vitamin D and acute myocardial infarction显示文摘Vitamin D deficiency is a prevalent condition,cutting across all ethnicities and among all age groups,and occurring in about 30%-50% of the population. Besides vitamin D established role in calcium homeostasis,its deficiency is emerging as a new risk factor for coronary artery disease. Notably,clinical investigations have suggested that there is an association between hypovitaminosis D and acute myocardial infarction(AMI). Not only has it been linked to incident AMI,but also to increased morbidity and mortality in this clinical setting. Moreover,vitamin D deficiency seems to predispose to recurrent adverse cardiovascular events,as it is associated with post-infarction complications and cardiac remodeling in patients with AMI. Several mechanisms underlying the association between vitamin D and AMI risk can be involved. Despite these observational and mechanistic data,interventional trials with supplementation of vitamin D are controversial. In this review,we will discuss the evidence on the association between vitamin D deficiency and AMI,in terms of prevalence and prognostic impact,and the possible mechanisms mediating it. Further research in this direction is warranted and it is likely to open up new avenues for reducing the risk of AMI. | Valentina Milazzo Monica De Metrio Nicola Cosentino Giancarlo Marenzi Elena Tremoli | 2017 | World Journal of Cardiology2017，9，1： | 7 |
| 2 | Role of oxidative stress in endothelial insulin resistance显示文摘The International Diabetes Federation estimates that 316million people are currently affected by impaired glucose tolerance(IGT).Most importantly,recent forecasts anticipate a dramatic IGT increase with more that 470million people affected by the year 2035.Impaired insulin sensitivity is major feature of obesity and diabetes and is strongly linked with adverse cardiometabolic phenotypes.However,the etiologic pathway linking impaired glucose tolerance and cardiovascular disease remains to be deciphered.Although insulin resistance has been attributed to inflammatory programs starting in adipose tissue,emerging evidence indicates that endothelial dysfunction may represent the upstream event preceding peripheral impairment of insulin sensitivity.Indeed,suppression of reactive oxygen species-dependent pathways in the endothelium has shown to restore insulin delivery to peripheral organs by preserving nitric oxide(NO)availability.Here we describe emerging theories concerning endothelial insulin resistance,with particular emphasis on the role oxidative stress.Complex molecular circuits including endothelial nitric oxide synthase,prostacyclin synthase,mitochondrial adaptor p66^(Shc),nicotinamide adenine dinucleotide phosphate-oxidase oxidase and nuclear factor kappa-B are discussed.Moreover,the review provides insights on the effectiveness of available compounds(i.e.,ruboxistaurin,sildenafil,endothelin receptor antagonists,NO donors)in restoring endothelial insulin signalling.Taken together,these aspects may significantly contribute to design novel therapeutic approaches to restore glucose homeostasis in patients with obesity and diabetes. | Francesco Paneni Sarah Costantino Francesco Cosentino | 2015 | World Journal of Diabetes2015，6，2： | 5 |
| 3 | High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX显示文摘 | Indrabahadur Singh Nihan Ozturk Julio Cordero Aditi Mehta Diya Hasan Claudia Cosentino Carlos Sebastian Marcus Kruger Mario Looso Gianni Carraro Saverio Bellusci Werner Seeger Thomas Braun Raul Mostoslavsky Guillermo Barreto | 2015 | Cell Research2015，25，7： | 5 |
| 4 | Potential Use of a Poultry Manure Digestate as a Biofertiliser:Evaluation of Soil Properties and Lactuca sativa Growth显示文摘Anaerobic digestion is a process that is widely used for the treatment of organic wastes. The digestate can be used as a soil amendment or crop fertiliser. The aims of our work were to evaluate 1) the physicochemical composition and pathogen content in a digestate from poultry manure, according to international regulations, and 2) the effect of its soil application on the major chemical and biological soil properties and on the growth of Lactuca sativa. The experiment consisted of two groups of pots(with and without crop). Treatments applied to each group were as follows: low and high doses of digestate and inorganic fertiliser, and no application(control)(low dose: 70 kg nitrogen(N) ha^(-1) and 21 kg phosphorus(P) ha^(-1); high dose: 210 kg N ha^(-1) and 63 kg P ha^(-1)). Soil samples were taken 7 and 34 d(harvest) after treatment applications. Heavy metal and pathogen contents in the digestate were below the upper limit values. Despite the high pH and electrical conductivity values of the digestate, both soil parameters presented acceptable values for crop growth. Although there were no initial increases in total inorganic N and available P in soil with digestate application, an increase in the fresh weight of crop was observed with the high dose application. This is probably associated with the slow nutrient release from the digestate during the development of the crop. Changes in the microbial community were temporary and occurred at the initial sampling stage of the experiment. | Natalia MóRTOLA Romina ROMANIUK Vanina COSENTINO Maximiliano EIZA Patricia CARFAGNO Pedro RIZZO Patricia BRES Nicolás RIERA Marcos ROBA Mariano BUTTI Daiana SAINZ Lucrecia BRUTTI | 2019 | Pedosphere2019，29，1： | 2 |
| 5 | Diabetes and Inflammation显示文摘 | Francesco Cosentino Gabriele Egidy Assenza | 2004 | Herz2004，，8： | 2 |
| 6 | Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study显示文摘Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway,thus affecting the development of levodopa-induced dyskinesia in Parkinson’s disease(PD).In the present study,we analyzed whether the use of this class of medication was associated with a reduced occurrence of levodopa-induced dyskinesia,using electronically-stored information of idiopathic PD patients enrolled at Novara University Hospital“Maggiore della Carità”.We conducted a retrospective case-control study identifying PD patients with dyskinesias(PwD;n=47)as cases.For each PwD we selected a non-dyskinetic control(NoD),nearly perfectly matched according to sex,Unified Parkinson’s Disease Rating Scale(UPDRS)part III score,and duration of antiparkinsonian treatment.Binary logistic regression was used to evaluate whether dyskinesias were associated with ACEi/ARBs use.Ninety-four PD patients were included,aged 72.18±9 years,with an average disease duration of 10.20±4.8 years and 9.04±4.9 years of antiparkinsonian treatment.The mean UPDRS part III score was 18.87±7.6 and the median HY stage was 2.In the NoD group,25(53.2%)were users and 22(46.8%)non-users of ACEi/ARBs.Conversely,in the PwD group,11(23.4%)were users and 36 non-users(76.6%)of this drug class(Pearson chi-square=8.824,P=0.003).Concerning general medication,there were no other statistically significant differences between groups.After controlling for tremor dominant phenotype,levodopa equivalent daily dose,HY 3-4,and disease duration,ACEi/ARBs use was a significant predictor of a lower occurrence of dyskinesia(OR=0.226,95%CI:0.080-0.636,P=0.005).Therefore,our study suggests that ACEi/ARBs may reduce levodopa-induced dyskinesia occurrence and,thanks to good tolerability and easy management,represent a feasible choice when dealing with the treatment of hypertension in PD patients.The study was approved by the Ethics Committee of Novara University Hospital“Maggiore della Carità”(CE 65/16)on July 27,2016. | Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca Marino Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 7 | Reactive oxygen species mediate endothelial dependent relaxations in tetrahydrobiopterin-deficient mice 显示文摘 | Cosentino F Barker JE Brand MP | 2001 | Arterioscler Thromb VASc Biol2001，21，4： | 1 |
| 8 | Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients:effect of cell stimulation and possible relevance for activation-induced apoptosis显示文摘 | Cosentino M Zaffaroni M Marino F | 2002 | J Neuroimmunol2002，133，： | 1 |
| 9 | High glucose causes up regu- lation of cyclooxygenase 2 and alters prostanoid profile in human en- dorthelial cells role of protein kinase C and reactive oxygen species 显示文摘 | Cosentino F Eto M Depaolis P | 2003 | Circulation2003，107，7： | 1 |
| 10 | Influence of dopa- mine receptor gene polymorphisms on circulating T lymphocytes: a pilot study in healthy subjects 显示文摘 | Cosentino M Ferrari M Kustrimovic N | 2015 | Hum Immunol2015，76，10： | 1 |
| 11 | Betunilic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents 显示文摘 | Kashiwada Y Hashimoto F Cosentino L M | 1996 | J Med Chem1996，39，5： | 1 |
| 12 | Diabetes and vascular disease:pathophysiology ,clinical consequences ,and medical therapy: Part Ⅰ显示文摘 | Creager MA Luscher TF Cosentino F | 2003 | Circulation2003，108，12： | 1 |
| 13 | Finite- time stabilization via dynamic output feedback 显示文摘 | F Amato M Afiola C Cosentino | 2006 | Automatica2006，42，2： | 1 |
| 14 | Effect of zofenopril and ramipril on cardiovascular mortality in patients with chronic heart failure 显示文摘 | Borghi C Cosentino E R Rinaldi E R | 2013 | Am J Cardiol2013，112，1： | 1 |
| 15 | Diabetes and Vascular Disease Pathophysiology,Clinical Conse- quences,and Medical Therapy:Part II显示文摘 | Beckman JA Paneni F Cosentino F | 2013 | Eur Heart J2013，34，31： | 1 |
| 16 | Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents 显示文摘 | KASHiWADA Y HASHIMOTO F COSENTINO LM | 1996 | J Med Chem1996，39，5： | 1 |
| 17 | Laparoscopy versus minilaparotomy in women with symptomatic uterine myomas:short-term and fertility results显示文摘 | Malzoni M Tinelli R Cosentino F | 2009 | Fertil Steril2009，12，： | 1 |
| 18 | Endogenous catecholamine synthesis,metabolism,storage and uptake in human neutrophils显示文摘 | Marino F Bombefli R | 1999 | Life Sciences1999，64，11： | 1 |
| 19 | Interaction between serum cholesterol levels and the renin-angiotensin system on the new onset of arterial hypertension in subjects with high-normal blood pressure 显示文摘 | Borghi C Veronesi M Cosentino E | 2007 | J Hypertens2007，25，： | 1 |
| 20 | Coronary atherosclerot- ic burden in patients with infection by CagA positive strains of Heli- cobacter pflori 显示文摘 | Niccoli G Franceschi F Cosentino N | 2010 | Coron Artery Dis2010，21，4： | 1 |
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