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| 1 | Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions显示文摘Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials. | Guido Giordano Massimo Pancione Nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario Rosario D’Andrea | 2017 | World Journal of Gastroenterology2017，23，32： | 7 |
| 2 | Substantially reduced expression of PIAS1 is associated with colon cancer development 显示文摘 | Coppola D Parikh V Boulware D | 2009 | J Cancer Res Clin Oncol2009，135，9： | 1 |
| 3 | First report of Aberia caffra and Quercus cerris as hosts of Inonotus rickii显示文摘 | Annesi T Coppola R D Amico L | 2005 | Plant Disease2005，89，： | 1 |
| 4 | Pancreatic fractures:the role of CT and the indications for endoscopic retrograte pancreatography显示文摘 | Coppola V Vallone G Verrengia D | 1997 | Radiol Med1997，94，4： | 1 |
| 5 | Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy显示文摘 | Grosso S Cordelli D Franzoni E Coppola G Capovilla G Zamponie N | 2007 | Seizure2007，16，4： | 1 |
| 6 | Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies 显示文摘 | Coppola D Szabo M Boulware D | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 7 | Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor显示文摘 | Ambrose D Resnicoff M Coppola D | 1994 | J Cell Physiol1994，159，1： | 1 |
| 8 | Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells显示文摘 | Song L Coppola D Livingston S | 2005 | Cancer Biol Ther2005，4，3： | 1 |
| 9 | Functional and evolutionary insights into human brain development through global tnmscriptome analysis显示文摘 | Johnson MB Kawasawa YI Mason CE Krsnik Z Coppola G Bogdanovié D | | 0，，04： | 1 |
| 10 | Diagnostic and pathogenetic implications of colorectal carcinomas with muhidirectional differentia- tion:a report of 4 cases 显示文摘 | Ouban A Nawab R A Coppola D | 2002 | Clin Colorectal Cancer2002，1，： | 1 |
| 11 | Prognostic significance of p53,bcl-2, vientin and S-100 positive langerhans cells in endometrial carcinomas显示文摘 | Fu L Nicosia SV | 1998 | Hum Pathol1998，29，： | 1 |
| 12 | Correlation of osteopontin correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies显示文摘 | Coppola D Szabo M Boulware D | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 13 | The miR-15a-miR-16-1 cluster controls prostatecancer by targeting multiple oncogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 14 | Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture 显示文摘 | INDOLFI C TORELLA D COPPOLA C | 2002 | Am J Physiol Heart Circ Physiol2002，283，2： | 1 |
| 15 | Correlation of osteopontinprotein expression and pathological stage across a wide variety oftumor histologies 显示文摘 | Coppola D Szabo M Boulware D | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 16 | The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 17 | Analysis of P53,P21WAF1,and TGF-B1in TGF-B1 protein expression predicts long survival显示文摘 | Coppola D Lu L Fruehauf JP | 1998 | Am J Clin Pathol1998，110，1： | 1 |
| 18 | The miR - 15a - miR - 16 - 1 cluster controis prostate cancer by targeting multiple oncogenic activities 显示文摘 | Bonci D Coppola V | 2008 | Nature Medicine2008，14，： | 1 |
| 19 | Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tu- morigenesis显示文摘 | Takahashi Y Coppola D Matsushita N | 2007 | Nat Cell Bid2007，9，10： | 1 |
| 20 | S-adenosylhomocysteine treatment of adult female fibroblasts alters X-chromosome inactivation and improves in vitro embryo development after somatic cell nuclear transfer 显示文摘 | Jeon B G Coppola G Perrault S D | 2008 | Reproduction2008，135，6： | 1 |
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