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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 3 | Fiber Optic Lever Displacement Transducer显示文摘 | Cook R O Hamm C W | 1979 | Applied Optics1979，18，19： | 1 |
| 4 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 5 | The deuterium to hydrogen ratios of sap in trees: implications for water sources and tree ring deuterium to hydrogen ratios显示文摘 | White J W C Cook E R Lawrence J R | 1985 | Geochimica Et Cosmochimiea Aeta1985，49，： | 1 |
| 6 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds显示文摘 | Hirt C W Amsden A A Cook H K | 1974 | J Comput Phys1974，14，： | 1 |
| 7 | Estimating paleorecharge and paleoclimate from unsaturated zone profiles显示文摘 | COOK P G EDMUNDS W M GAYE C B | 1992 | Water Resources Research1992，28，： | 1 |
| 8 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 9 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 10 | Betaine in sub- acute and sub-chronic rat studies显示文摘 | HAYES K C PRONCZUK A COOK M W | 2003 | Food Chem Toxicol2003，41，12： | 1 |
| 11 | The inner centro- mere protein (INCENP) antigens: movement from inner een- tromere to midbody during mitosis显示文摘 | Cooke C A Heck M M Earnshaw W C | 1987 | J Cell Biol1987，105，5： | 1 |
| 12 | A synthetic oestrus- exciting compound显示文摘 | Cook J W Dodds E C Hewtt C L | 1933 | Nature1933，131，： | 1 |
| 13 | Expression of the cyclin dependent kinase inhibitor p27 in keratocanthoma显示文摘 | HU W COOK T OH C W | 2000 | J Am Acad Dermatol2000，42，： | 1 |
| 14 | Construction of a 1° x 1° fossil fuel emission data set for carbonaceous aerosol and implementation and radiative impact in the ECHAM4 model显示文摘 | Cooke W F Liousse C | 1999 | Journal of Geophysical Research1999，104，22： | 1 |
| 15 | Analysis of deformation of vertically loaded piles显示文摘 | Cooke R W Wroth C P | 1978 | Proc J GT Div ASCE1978，104，12： | 1 |
| 16 | Photopolymeri- zation of N,N-dimethylaminobenzyl alcohol as amine co- initiator for light-cured dental resins显示文摘 | SCHROEDER W F COOK W D VALLO C I | 2008 | Dental Materials2008，24，5： | 1 |
| 17 | Effect of partial middle turbinectomy on nasal airflow and resistance 显示文摘 | COOK P R BEGEGNI A BRYANT W C | 1995 | Otolaryngol Head Neck Surg1995，113，： | 1 |
| 18 | An arbitrary Lagrangian Eulerian computing method forall follow speeds 显示文摘 | HIRT C W AMSDEN A A COOK J L | 1974 | J Comput Plays1974，14，3： | 1 |
| 19 | An arbitrary lagrangian-eulerian computing method for all flow speeds显示文摘 | Hirt C W Amsden A A Cook J L | 1974 | Journal of Computational Physics1974，14，3： | 1 |
| 20 | The ra tios of sap in trees : Implications for water sources and tree ring ratios显示文摘 | WHITE J W C COOK E R LAWRENCE J R etal | 1985 | Geochimica et Cosmochimica Acta1985，49，23： | 1 |
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