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| 1 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 2 | A cobweb bidding model for competitive electricity markets显示文摘 | Contreras J Candiles O Ignacio de la Fuente J | 2002 | IEEE Transaction on Power Systems2002，17，1： | 1 |
| 3 | Comparison of a new type of polytetrafluoroethylene patch (Mycro Mesh)and polypropylene prosthesis (Marlex) for repair of abdominal wall defects显示文摘 | Bello JM Buja J Contreras LA | 1996 | J Am Coll Surg1996，183，1： | 1 |
| 4 | Auction design in day-ahead electricity markets (republished)显示文摘 | Contreras J Candiles O De la Fuente J | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 5 | Tissue response to polypropylene meshes used in the repair of abdominal wall defects 显示文摘 | Bellon JM Contreras LA Bujan J | 1998 | Biomaterials1998，19，79： | 1 |
| 6 | 1,25-Vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathway 显示文摘 | Hlaing SM Garcia LA Contreras JR | 2014 | J Mol Endocrinol2014，53，3： | 1 |
| 7 | Simulating oligopolistic pool-based electricity markets:a multiperiod approach显示文摘 | Torre S de la Conejo A J Contreras J | 2003 | IEEE Transactions on Power Systems2003，18，4： | 1 |
| 8 | Auction design in day-ahead electricity markets(republished)显示文摘 | Candiles O De la Fuente J I | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 9 | Research fronts in library and information science in Spain (1985–1994)显示文摘 | F. Moya Anegón E. Jiménez Contreras Mercedes De La Moneda Corrochano | 1998 | Scientometrics1998，，2： | 1 |
| 10 | Finding multiperiod Nash equilibria in pool-based electricity markets 显示文摘 | De La TORRE S CONTRERAS J CONEJO A J | 2004 | IEEE Transactions on Power System2004，19，1： | 1 |
| 11 | A cobweb bidding model for competitive electricity market显示文摘 | CONTRERAS J CANDILES O IGNACIO De La FUENTE J | 2002 | IEEE Transactions on Power System2002，17，1： | 1 |
| 12 | Optimal coordinated wind-hydro bidding strategies in day-ahead markets显示文摘 | Sanchez de la Nieta A A Contreras J Muiloz J I | 2013 | Power Systems IEEE Transactions on2013，28，2： | 1 |
| 13 | Effectiveness of an Intervention to Provide Information to Patients with Hypertension as Short Text Message and Reminders Send to Their Mobile Phone (HTA-Alert)显示文摘 | Marquez Contreras E de la Figuera yon Wichmann M Gil Guill6n V | 2004 | Aten Primaria2004，34，8： | 1 |
| 14 | A cobweb bidding model for competitive electricity markets显示文摘 | Contreras J de la Fuente J I Gomez T | 2002 | IEEE Trans on Power System2002，17，1： | 1 |
| 15 | Role of angiotension Ⅱ AT1 receptor blockers in the trealment of arterial hypertension显示文摘 | Contreras F De la Parte MA Cabrera J | 2003 | Am J Ther2003，10，6： | 1 |
| 16 | The use of biomaterials in the repair of abkominal wall defects:a comparative study between polypropylene meshes (Marlex) and a new polytetrafluoroethylene prosthesis (Dual Mesh)显示文摘 | Bellon JM Contreras LA Bujan J | 1997 | J Biomater Appl1997，12，2： | 1 |
| 17 | Power cngineering lab:electricity market simulator显示文摘 | CONTRERAS J CONEJO A J de la TORRE S | 2002 | IEEE Transactions on Power Systems2002，17，2： | 1 |
| 18 | Experience with an electricity market simulation tool显示文摘 | Contreras J Conejo A J La Torre S | 2003 | Production Planning and Control2003，14，2： | 1 |
| 19 | Power engineering lab: electricity market simulator显示文摘 | Contreras J Conejo A J De la Torre S | 2006 | IEEE Trans on Power Systems2006，17，2： | 1 |
| 20 | Simulating oligopolistic pool-based electricity markets: a multiperiod approach 显示文摘 | De La TORRE S CONEJO A J CONTRERAS J | 2003 | IEEE Transactions on Power Systems2003，18，4： | 1 |
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