|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Autophagy is required for self-renewal and differentiation of adult human stem cells显示文摘 | Souzan Salemi Shida Yousefi Mihai A Constantinescu Martin F Fey Hans-Uwe Simon | 2012 | Cell Research2012，22，2： | 17 |
| 2 | 2-D eddy resolving simulations of flow past a circular array of cylindrical plant stems显示文摘In the present study, 2-D large eddy simulations(LES) are conducted for flow past a porous circular array with a solid volume fraction(SVF) of 8.8%, 15.4% and 21.5%. Such simulations are relevant to understanding flow in natural streams and channels containing patches of emerged vegetation. In the simulations discussed in the paper, the porous cylinder of diameter D contains a variable number of identical solid circular cylinders(rigid plant stems) of diameter d= 0.048 D. Most of the simulations are conducted at a Reynolds number of 2 100 based on the diameter D and the velocity of the steady uniform incoming flow. Though in all cases wake billows are shed in the regions where the separated shear layers(SSLs) forming on the sides of the porous cylinder interact, the effect of these wake billows on the mean drag is different. While in the high SVF case(21.5%), the total drag force oscillates quasi-regularly in time, similar to the canonical case of a large solid cylinder, in the cases with a lower SVF the shedding of the wake billows takes place sufficiently far from the cylinder such that the unsteady component of the total drag force is negligible. The mean amplitude of the oscillations of the drag force on the individual cylinders is the largest in a streamwise band centered around the center of the porous cylinder, where the wake to wake interactions are the strongest. In all cases the maximum drag force on the individual cylinders is the largest for the cylinders directly exposed to the flow, but this force is always smaller than the one induced on a small isolated cylinder and the average magnitude of the force on the cylinders directly exposed to the flow decreases monotonically with the increase in the SVF. Predictions of the global drag coefficients, Strouhal numbers associated with the wake vortex shedding and individual forces on the cylinders in the array from the present LES are in very good agreement with those of 2-D direct numerical simulations conducted on finer meshes, which suggests LES is a better option to numerically investigate flow in channels containing canopy patches, given that LES is computationally much less expensive than DNS at high Reynolds number. To prove this point, the paper also discusses results of 2-D LES conducted at a much higher Reynolds number, where the near-wake flow is strongly turbulent. For the higher Reynolds number cases, where the influence of the turbulence model is important, the effect of the sub-grid scale model and the predictive capabilities of the unsteady Reynolds averaged Navier-Stokes(RANS) approach to predict flow past porous cylinders are discussed. | Kyoungsik Chang George Constantinescu Sanghyun Park | 2018 | Journal of Hydrodynamics2018，30，2： | 8 |
| 3 | Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases 显示文摘 | Edwards LJ Constantinescu CS | 2009 | lnflamm Allergy Drug Targets2009，8，3： | 6 |
| 4 | Inflammatory model in patients with primary open angle glaucoma and diabetes显示文摘AIM: To assess the inflammatory cytokines expression in aqueous humor in diabetic primary open angle glaucoma(POAG) patients. METHODS: A cross-sectional study on 87 eyes, distributed as following: 26 eyes from diabetic patients, 16 eyes with POAG and 21 eyes from diabetic POAG patients; healthy controls(24 eyes) were recruited from patients undergoing conventional cataract surgery. A volume of 100 μL of aqueous humor(AH) was collected during phacoemulsification and 21 inflammatory markers were quantified using a Luminex~? cytometric bead assay: IL-1 Ra, IL-1α, IL-1β, IL-5, IL-6, IL-10, IL-17, GM-CSF, IFNγ, CCL2, CCL3, CCL4, CXCL5, CXCL8, bFGF, VEGF, TNFα. Main changes in cytokine profile were analyzed and compared between groups. Data on demographics, duration of glaucoma, intraocular pressure(IOP), number of anti-glaucoma substances were recorded for correlation analysis and prediction models. RESULTS: Significant differences in cytokine expression between groups were detected for CXCL5(P<0.001), CXCL8(P=0.004), IL-1α(P<0.001), IL-2(P<0.001), CCL4(P=0.003), CCL5(P<0.001) and TNFα(P=0.05). Post-hoc analysis identified IL-2(P=0.009) and CXCL5(P<0.001) as 'separation markers' between POAG and diabetic POAG eyes. In POAG patients, the 'separation markers' could highly predict the TNFα levels F(1, 16)=14.639, P<0.001, whereas in diabetic patients F(1, 24)=4.844, P=0.006 and diabetic POAG patients F(1, 19)=2.358, P=0.05 the level of prediction was inferior.CONCLUSION: Our results reveal an inflammatory model based on increased TNFα levels in POAG eyes.Simultaneous co-stimulatory molecules and additional inflammatory pathways need to be further explored in diabetic POAG cases, since the prediction model could only partially explain the increased TNFα level in this category of patients. | Anca Pantalon Otilia Obada Daniela Constantinescu Crenguta Feraru Dorin Chiselita | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 4 |
| 5 | Stem cell generation and choice of fate:roleof cytokines and cellular microenviroment显示文摘 | CONSTANTINESCU SN | 2000 | J Cell Mol Med2000，4，4： | 1 |
| 6 | Heteroclinic Orbits in the T and the Lu Systems 显示文摘 | Tigan G Constantinescu D | 2009 | Chaos Solitons & Fractals2009，42，1： | 1 |
| 7 | Improvement of thermoelectric properties in Ca3Co4O9 ceramics by Ba doping 显示文摘 | CONSTANTINESCU G RASEKH S TORRES M A | 2015 | Journal of Materials Science Materials in Electronics2015，26，6： | 1 |
| 8 | Variable MLH1 promoter methylation patterns in endometrial carcinomas of endometrioid subtype lacking DNA mismatch repair显示文摘 | Helmle KE Otto C J Constantinescu G | 2005 | Int J Gynecol Cancer2005，15，6： | 1 |
| 9 | A Computationalframework for uncertainty quantification and stochastic optimization in unit commitment with wind power generation显示文摘 | Constantinescu E M Zavala V M Rocklin M | 2011 | IEEE Transactions on Pow- er Systems2011，26，1： | 1 |
| 10 | Ensem- ble-based chemical data assimilation, h general ap- proach 显示文摘 | Constantinescu E M Sandu A Chai T | 2007 | Quarterly Journal of the Royal Meteoro- logical Society2007，133，626： | 1 |
| 11 | Pro-jected number of people with Parkinson disease in the most populous nations 2005 through 2030 显示文摘 | Dorsey ER Constantinescu R Thompson JP | 2007 | Neurology2007，68，5： | 1 |
| 12 | Outcomes of subsequent pregnancies in female kidney transplant recipients 显示文摘 | Constantinescu S Silva P Khan SS | 2007 | Am J Transplant2007，，2： | 1 |
| 13 | Captopril and lisinopril suppress production of interleukin-12 by human peripheral blood mononuclear cells显示文摘 | Constantinescu CS Goodman DBP Ventura ES | 1998 | Immunol Lett1998，62，： | 1 |
| 14 | Turbulence modeling applied to flow over a sphere 显示文摘 | Constantinescu G S Chapelet M Squires K | 2003 | AIAA Journal2003，41，9： | 1 |
| 15 | Variable MLH1 promoter methylation patterns in endometrial carcinomas of endometrioid subtype lacking DNA mismatch repair显示文摘 | Helmle KE Otto CJ Constantinescu G | 2005 | Gynecol Cancer2005，15，6： | 1 |
| 16 | LES and DES investigations of turbulent flow over a sphere at Re = 10,000 flow 显示文摘 | Constantinescu G S Squires K D | 2003 | Turbulence and Combustion2003，70，14： | 1 |
| 17 | Biochemical characterization and quantitation of the collagenous components of urethral stricture tissue 显示文摘 | Baskin LS Constantinescu SC Howard PS | 1993 | J Urol1993，150，2： | 1 |
| 18 | Imaging athero- sclerosis by carotid intima-media thickness in vivo: how to, where and in whom 显示文摘 | Onut R Balanescu A P Constantinescu D | 2012 | Maediea ( Buchar )2012，7，2： | 1 |
| 19 | Projected number of people with Parkinson disease in the most popu- lous nations, 2005 through 2030显示文摘 | Dorsey ER Constantinescu R Thompson JP | 2007 | Neurology2007，68，： | 1 |
| 20 | Mining for JAK-STAT mutations in cancer显示文摘 | Constantinescu SN Girardot M Pecquet C | 2008 | Trends Biochem Sci2008，33，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员