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| 1 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 2 | Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations显示文摘BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients.They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller glia.AIM To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.METHODS In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D culture.Putative progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was investigated.RESULTS Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal organoids.Such retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as monolayers.CONCLUSION Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies. | Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink Poul Hyttel Mark Gillies Henriette Haukedal Miriam Kolko | 2020 | World Journal of Stem Cells2020，12，10： | 2 |
| 3 | Nucleation of microcellular thermoplastic foam with additives: part I: theoretical considerations显示文摘 | Colton J S Suh N P | 1987 | Polymer Engineering and Science1987，27，7： | 2 |
| 4 | Nucleation of microcellular foam:theory and practice显示文摘 | Colton J S Suh N P | 1987 | Polymer Engineering and Science1987，27，7： | 2 |
| 5 | Nucleation of microcellular thermoplastic foam with additives: part Ⅱ: experimental results and discussion显示文摘 | Colton J S Suh N P | 1987 | Polymer Engineering and Science1987，27，7： | 2 |
| 6 | Apolipoprotein E and Alzheimer’s disease显示文摘Genetic variation in apolipoprotein E(APOE)influences Alzheimer’s disease(AD)risk.APOEε4 alleles are the strongest genetic risk factor for late onset sporadic AD.The AD risk is dose dependent,as those carrying one APOEε4 allele have a 2-3-fold increased risk,while those carrying twoε4 alleles have a 10-15-fold increased risk.Individuals carrying APOEε2 alleles have lower AD risk and those carrying APOEε3 alleles have neutral risk.APOE is a lipoprotein which functions in lipid transport,metabolism,and inflammatory modulation.Isoform specific effects of APOE within the brain include alterations to Aβ,tau,neuroinflammation,and metabolism.Here we review the association of APOE with AD,the APOE isoform specific effects within brain and periphery,and potential therapeutics. | Benjamin R.Troutwine Laylan Hamid Colton R.Lysaker Taylor A.Strope Heather M.Wilkins | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 7 | The Nucleation of Microcellular Thermoplastic Foam with Additives: Part Ⅱ-Experimental Results and Discussion显示文摘 | J S Colton N P Suh | 1987 | Polymer Engineering and Science1987，27，7： | 1 |
| 8 | Verification of the United Nations Chemical Weapons Convention:the application of electrospray mass spectrometry 显示文摘 | Borrett VT Mathews RJ Colton R | 1996 | Rapid Commun Mass Spectrom1996，10，1： | 1 |
| 9 | Bioengineering in devel- opment of the hybrid artificial pancreas 显示文摘 | Colton CK Avgoustiniatos ES | 1991 | J Biomech Eng1991，113，2： | 1 |
| 10 | The Nucleation of Microcellular Thermoplastic Foam with Additives: Part Ⅰ: Theoretical Considerations 显示文摘 | Colton J S Suh N P | 1987 | Polymer Engineering & Science1987，27，： | 1 |
| 11 | Fuactures of the olecranon in adults显示文摘 | Colton CL | 1998 | J Bone Jiont Surg(Am)1998，80，5： | 1 |
| 12 | The Nucleation of Microcellular Thermoplastic Foam With Additives: Part (I) Theoretical Considerations 显示文摘 | J S Colton N P Suh | 1987 | Polym Eng & Sci1987，27，： | 1 |
| 13 | Electrospy mass spectrometric study of the nature and lability of cationic complexes generated by the reaction of solutions of neutral iron(Ⅲ),cobalt(Ⅲ),nickel(Ⅲ) and copper(Ⅲ) dithiocarbamates with nitrosonium tetrafluoroborate显示文摘 | Bond A M Colton R D′Agostion D | 1993 | Inorg Chem1993，32，： | 1 |
| 14 | Nucleation of microcellular foam:theory and practice显示文摘 | J S Colton N P Suh | 1987 | Polym Eng Sci1987，27，： | 1 |
| 15 | Nucleation of microcellular foam:Theory and practice显示文摘 | N P Suh | 1987 | Polym Erg Sci1987，27，： | 1 |
| 16 | Scanning probe microscopy显示文摘 | Colton Richard J Baselt David R Dufrêne Yves F Green John-Bruce D Lee Gil U | 1997 | Chemical Biology1997，1，3： | 1 |
| 17 | Location and timing of initial osteoid deposition in postmeningitic labyrinthitis ossificans determined by multiple fluorescent labels显示文摘 | Tinling SP Colton J Brodie HA | 2004 | Laryngoscope2004，114，4： | 1 |
| 18 | Dynamic triaxial tests of high strength concrete显示文摘 | Gran J K Florence A L Colton J D | 1989 | Journal of Engineering Mechanics ASCE1989，115，5： | 1 |
| 19 | The Nucleation of microcellular thermoplastic foam with additives (Part I) : Theoretical considerations 显示文摘 | COLTON J S SUH N P | 1987 | Polym Eng Sci1987，27，： | 1 |
| 20 | Nucleation of microcellular foam:theory and practice显示文摘 | J S Colton N P Suh | 1987 | Polym Eng Sci1987，27，： | 1 |
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