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| 1 | Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion显示文摘AIM To examine the role that enzyme Acyl-CoA:diacylglycerol acyltransferase-1(DGAT1) plays in postprandial gut peptide secretion and signaling.METHODS The standard experimental paradigm utilized to evaluate the incretin response was a lipid challenge.Following a lipid challenge,plasma was collected via cardiac puncture at each time point from a cohort of 5-8 mice per group from baseline at time zero to 10 h.Incretin hormones [glucagon like peptide-1(GLP-1),peptide tyrosine-tyrosine(PYY) and glucose dependent insulinotropic polypeptide(GIP)] were then quantitated.The impact of pharmacological inhibition of DGAT1 on the incretin effect was evaluated in WT mice.Additionally,a comparison of loss of DGAT1 function either by genetic ablation or pharmacological inhibition.To further elucidate the pathways and mechanisms involved in the incretin response to DGAT1 inhibition,other interventions [inhibitors of dipeptidyl peptidase-IV(sitagliptin),pancreatic lipase(Orlistat),GPR119 knockout mice] were evaluated.RESULTS DGAT1 deficient mice and wildtype C57/BL6J mice werelipid challenged and levels of both active and total GLP-1 in the plasma were increased.This response was further augmented with DGAT1 inhibitor PF-04620110 treated wildtype mice.Furthermore,PF-04620110 was able to dose responsively increase GLP-1 and PYY,but blunt GIP at all doses of PF-04620110 during lipid challenge.Combination treatment of PF-04620110 and Sitagliptin in wildtype mice during a lipid challenge synergistically enhanced postprandial levels of active GLP-1.In contrast,in a combination study with Orlistat,the ability of PF-04620110 to elicit an enhanced incretin response was abrogated.To further explore this observation,GPR119 knockout mice were evaluated.In response to a lipid challenge,GPR119 knockout mice exhibited no increase in active or total GLP-1 and PYY.However,PF-04620110 was able to increase total GLP-1 and PYY in GPR119 knockout mice as compared to vehicle treated wildtype mice.CONCLUSION Collectively,these data provide some insight into the mechanism by which inhibition of DGAT1 enhances intestinal hormone release. | Benjamin S Maciejewski Tara B Manion Claire M Steppan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，4： | 2 |
| 2 | Analysis of soil wetting and solute transport in subsurface trickle irrigation显示文摘 | Cote Claire M Bristow Keith L Charlesworth pllilip B | 2003 | Irrigation Science2003，22，3： | 1 |
| 3 | Morphology, origin and infrared microthermometry of fluid inclusions in pyrite from the Radka epithermal copper deposit, Srednogorie zone, Bulgaria显示文摘 | Kalin Kouzmanov Laurent Bailly Claire Ramboz Olivier Rouer Jean-Michel Bény | 2002 | Mineralium Deposita (-)2002，，6： | 1 |
| 4 | Endocrinepancreas developmet in growth-retarded human infants显示文摘 | BLONDEAU B CLAIRE M | 2002 | Diabetes2002，51，： | 1 |
| 5 | TMS1,a novel pro-apoptotic caspase recruitment domain protein,is a target ofmethylation-induced gene silencing in human breast cancers显示文摘 | Kerry E C Beth/M Claire E B | 2000 | Cancer Res2000，60，22： | 1 |
| 6 | The Effects of Microbiotic Soil Crustson Soil Water Loss显示文摘 | George D B Roundy B A Clair L L | 2003 | Arid Land Research and Management2003，17，2： | 1 |
| 7 | Circulating transforming growth factor beta 1 (TGF-betal) in Guillain-Barre syndrome : decreased concentrations in the early course and increase with motor function显示文摘 | Crange A Blec L Clair B | 1998 | J Neurol NeurosurgPsychiatry1998，64，2： | 1 |
| 8 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 9 | Precautions for the structural analysis of the gelatinous layer in tension wood 显示文摘 | CLAIR B GRIL J BABA K | 2005 | IAWA Journal2005，26，2： | 1 |
| 10 | Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophagns显示文摘 | Zhao B Song J St Clair RW | 2007 | Am J Physiol Cell Physiol2007，292，1： | 1 |
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| 12 | Delta-opioid receptors are critical for tricyclic anti-depressant treatment of neuropathic allodynia显示文摘 | MALIKA B CLAIRE GR IPEK Y | 2008 | Biological Psychiatry2008，63，6： | 1 |
| 13 | Simultaneous hydrodesulfurization, hydrodeoxygenation, and hydrogenation with molybdenum carbide 显示文摘 | Dhandapani B Clair T S Oyama S T | 1998 | Applied Catalysis1998，168，： | 1 |
| 14 | Simultaneous optimization of capsule and tablet formulation using response surface methodology 显示文摘 | Iskandarani B Clair J H Patel P | 1993 | Drug Dev Ind Pharm1993，19，16： | 1 |
| 15 | Mechanical behavior of cellulose microfibrils in tension wood in relation with maturation stress generation 显示文摘 | CLAIR B ALMERAS T YAMAMOTC H | 2006 | Biophysical Journal2006，91，3： | 1 |
| 16 | Thalidomide in systemic mastocytosis: results from an open‐label, multicentre, phase II study显示文摘 | Bérengère Gruson Olivier Lortholary Danielle Canioni Olivia Chandesris Fanny Lanternier Julie Bruneau Bernard Grosbois Cristina Livideanu Claire Larroche Isabelle Durieu Stéphane Barete Henri Sevestre Momar Diouf Guillaume Chaby Jean‐Pierre Marolleau Patr | 2013 | Br J Haematol2013，，3： | 1 |
| 17 | Incidence and Survival Rates for Female Malignant Germ Cell Tumors 显示文摘 | Harriet OS Marianne B Claire FV | 2006 | Obstet Gynecol2006，107，5： | 1 |
| 18 | DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways:fail-safe protection against carcinogenesis显示文摘 | Carol B Harris B Claire M at al | 2002 | Murat Pes2002，511，： | 1 |
| 19 | Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora显示文摘 | Ann Marie B Bernard JM Claire ES | 1992 | J Clin Microbiol1992，30，： | 1 |
| 20 | Leucine supplementation im- proves muscle protein synthesis in elderly men independently of hy- peraminoacidaemia显示文摘 | Isabelle R Mich~le B Claire S | 2006 | The Journal of Physilolgy2006，575，： | 1 |
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