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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Comparison of potent odorants in a faltered coffee brew and in an instant coffee beverage by aroma extract dilution analysis (AEDA)显示文摘 | SANZ C CZERNY M CID C | 2002 | European Food Research and Technology2002，214，： | 1 |
| 3 | In situ synthesis of magnetic multiwalled carbon nanotube composites for the clean - up of ( fluoro ) quinolones from human plasma prior to ultrahigh pressure liquid chromatography analysis 显示文摘 | Morales -Cid G Fekete A Simonet B M | 2010 | Anal Chem2010，82，： | 1 |
| 4 | Oxidative stress by Helicobacter pylofi causes apoptosis through mitochondrial pathway in gastric epithelial cells显示文摘 | Calvino - FernOndez M Benito - Martinez S Parra - Cid T | 2008 | Apoptosis2008，13，10： | 1 |
| 5 | Platelet concentrates prepared and stored under currently optimal conditions:minor impact on platelet adhesive and cohesive function after storage 显示文摘 | Lozano M Estebanell E Cid J | 1999 | Transfusion1999，39，9： | 1 |
| 6 | Application of double loop electrochemical potential dynamic reactivation test to austenitic and duplex stainless steels 显示文摘 | Lopez N Cid M Puiggali M | 1997 | Materials Science and Engineering1997，229，1： | 1 |
| 7 | Tranexamic acid reduces allogeneic red cell transfu- sions in palients undergoing total knee arthroplasty: results of a meta- analysis of randomized controlled trials 显示文摘 | Cid J Lozano M | 2005 | Transfusion2005，45，8： | 1 |
| 8 | The cryoglobulinaemias显示文摘 | Ramos-Casals M Stone JH Cid MC | 2012 | Lancet2012，379，9813： | 1 |
| 9 | An integrative evolution theory of histo-blood group ABO and related genes显示文摘 | Yamamoto F Cid E Yamamoto M | 2014 | Sci Rep2014，4，： | 1 |
| 10 | BDNF variability in opioid addicts and response to methadone treatment: preliminary findings显示文摘 | de Cid R Fonseea F Grataco' s M | 2008 | Genes Brain Behav2008，7，： | 1 |
| 11 | The clinical implications of platelet transfusions associated with ABO or Rh(D)incompatibil- ity显示文摘 | Lozano M Cid J | 2003 | Transfus Med Rev2003，17，1： | 1 |
| 12 | The clinical implications of platelet transfusions associated with ABO or Rh (D) incompatibility显示文摘 | Lozano M Cid J | 2003 | Transfus Med Rev2003，17，1： | 1 |
| 13 | Analysis and enhancement of astaxanthin accumulation in Haematococcus pluvialis显示文摘 | Orosa M Franqueira D Cid A | 2005 | Bioresouree Technology2005，96，： | 1 |
| 14 | Treatment of polymyalgia rheumatica: a systematic review 显示文摘 | Hernmdez-Rodriguez J Cid M C L6pez-Soto A | 2009 | Archives Internal Medicine2009，169，20： | 1 |
| 15 | Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty:results of a meta-analysis of randomized controlled trials显示文摘 | Cid J Lozano M | 2005 | Transfusion2005，45，8： | 1 |
| 16 | Sources of intense geomagnetic storms over the rise of solar cycle 23显示文摘 | Cid C Hidalgo M A Saiz E Y Cerrato | 2004 | Solar Phys2004，，： | 1 |
| 17 | Biogenic amines in traditional fermented sausages produced in selected European countries 显示文摘 | Latorre- Moratalla M L Veciana- Nogus T Borer- Cid S | 2007 | Food Chemistry2007，107，2： | 1 |
| 18 | Tranexamic acid reduces allogeneic red celltransfusions in patients undergoing total knee arthroplasty: re-sults of a meta-analysis of randomized controlled trials 显示文摘 | Cid J Lozano M | 2005 | Transfusion2005，45，8： | 1 |
| 19 | Concentrations of polybrominated di- phenyl ethers ,hexachlorobenzenne and polycyclic aromatic hydrocarbons in various foodstuffs before and after cooking显示文摘 | Gemma Perell6 Roser Marti - Cid Victoria Castell Juan M Llobet Jose L Domingo | 2009 | Food and Chemical Toxicology2009，，47： | 1 |
| 20 | Excellent Dye Fixa- tion on Cotton Dyed in Supercritical Carbon Dioxide Using Fluorotri- azine Reactive Dyes 显示文摘 | FERNANDEZ Cid M V SPRONSEN J | 2005 | Green Chemistry2005，7，8： | 1 |
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