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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | In utero transplantation of human bone marrow-derived multipotent mesenchymal stem cells in mice显示文摘 | Chou SH Kuo TK Liu M Lee OK | 2006 | 中国生物学文摘2006，20，5： | 6 |
| 3 | Fiber inclination model of three dimensional textile structural composites 显示文摘 | Yang J M Chou T W | 1986 | Journal of Composites Material1986，20，5： | 3 |
| 4 | 经颅磁刺激用于治疗帕金森病运动障碍显示文摘帕金森病(ParkinsoffsDisease,PD)是一种进展性神经退行性疾病,在60岁以上的老年人中接近1%罹患PD,在80岁以上的老年人中则为4%。目前的治疗方法包括药物治疗和手术治疗,后者包括深部脑刺激。在过去的二十年里,重复经颅磁刺激(RepetitiveTtranscranialMagneticStimulation,rTMS)~渐被认为或是治疗PD的方案。本荟萃分析旨在帮助医疗人员更好地理解rTMS用于治疗帕金森病运动障碍的疗效。 | Chou YH Hickey PT Sundman M 吴毅 | 2015 | 中国康复2015，30，5： | 3 |
| 5 | Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells 显示文摘 | Chou C C Pan S L Teng C M | 2003 | Eur J Pharm Sci2003，19，5： | 2 |
| 6 | Layered perovskites with giant spontaneous polarization for nonvolatile memories 显示文摘 | CHOU U JANG M G KIM M G | 2002 | Phys Rev Lett2002，89，87： | 2 |
| 7 | An analytical and experimental study of strength and failure behaviour of plain weave composites显示文摘 | Ito M Chou TW | 1998 | J composite Materials1998，32，1： | 2 |
| 8 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 9 | Differential expression of the down regulatory function of CD8 cells in Triehosanthin-induced immunosupplession and its genetic control in humans显示文摘 | Chou KY Chan M Bias WB | 1996 | Eur J Immunogenetics1996，23，： | 1 |
| 10 | Rescue for acute myocarditis with shock by extracorporeal membrane oxygenation显示文摘 | Chen YS Wang M J Chou NK | 1999 | Ann Thorac Surg1999，68，6： | 1 |
| 11 | Transforming growth factor-1 up-regulation is independent of angiotensin in paraquat-induced lung fibrosis显示文摘 | CHEN C M CHOU H C HSU H H | 2005 | Toxicol2005，216，： | 1 |
| 12 | Response of the newborn ureteropelvic iunction complex to indneed and later reversed partial ureteral obstruction in the rabbit model显示文摘 | Cheng EY Maizels M Chou P | 1993 | J Urol1993，150，2： | 1 |
| 13 | β-Rhizobia from Mimosa pigra, a newly discovered invasive plant in Taiwan 显示文摘 | CHEN W M JAMES E K CHOU J H | 2005 | New Phytologist2005，168，3： | 1 |
| 14 | Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties显示文摘 | Price MJ Chou CC Frantzen M | 2006 | Int J Cardiol2006，111，2： | 1 |
| 15 | The fold of α-synuclein fibrils显示文摘 | Vilar M Chou HT Lührs T | 2008 | Proc Natl Acad Sci USA2008，105，25： | 1 |
| 16 | Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice显示文摘 | Chou M W Yan J Nichols J | 2003 | Cancer Lett2003，193，： | 1 |
| 17 | Direct observation of short-circuit diffusion during the formation of a single cupric oxide nanowire显示文摘 | Cheng C L Ma Y R Chou M H | 2007 | Nanotechnology2007，18，24： | 1 |
| 18 | Isolation and characterization of 23 polymorphic microsatellite markers for diversity and stock analysis in tiger shrimp (Penaeus monodon) 显示文摘 | Yu W P Chou H H You E M | 2004 | Mol Eco Notes2004，4，： | 1 |
| 19 | Reactively sputtered N-doped titanium oxide films as visible-light photoeatalyst 显示文摘 | WONG M S CHOU H P YANG T S | 2006 | Thin Solid Films2006，494，12： | 1 |
| 20 | Surface heat budgets and sea surface temperature in the Pacific warm pool during TOGA COARE 显示文摘 | Chou S H Zhao W Chou M D | 2000 | J Climate2000，13，3： | 1 |
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