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| 1 | 无机活性元素骨组织工程支架材料修复山羊颌骨缺损显示文摘目的:应用无机活性元素骨组织工程支架材料,对山羊的下颌骨角部大型箱状缺损施行骨重建,观察支架材料骨构建效能和生物相容性的情况。方法:实验于2004-02/12在安徽医科大学附属省立医院实验中心及相关实验室完成。①实验材料:无机活性元素骨组织工程支架材料由美国波士顿大学分子生物相容学研究室研制提供;21只雌性健康山羊由安徽医科大学动物实验中心(皖医实动准字01号)提供,实验过程中动物处置符合动物伦理学标准。②实验方法:取山羊15只,按4,8,12周3个时间点分为3组,位下颌角部手术制备30 mm×25 mm×10 mm的大型箱状缺损。采用自身配对设计,左侧置入支架材料为实验组,右侧空白对照为对照侧;剩余6只山羊为对照组,不手术。③观察指标:术后4,8,12周应用X射线片、组织学和放射性核素显像观察缺损区新骨形成情况;并测定骨密度;应用血液学检查及骨髓基质细胞体外复合细胞培养评价材料的生物相容性。结果:①一般观察:实验山羊无手术死亡,创口Ⅰ期愈合。②X射线片:实验侧有渐进性骨密度增高,阻射影逐级增强,对照侧呈透光阴影。③放射性核素显像:实验侧有较明显的核浓聚和再生血管化现象,对照侧无骨重建,故无骨代谢变化。④骨密度测量系数:实验侧呈递增式上升,对照侧维持较低水平,提示无自发性成骨。⑤组织学观察:实验侧呈时间递增性骨重建现象,在12周时新骨已完全形成并钙化基本完成,而对照侧直到12周仍无成骨现象。⑥生物相容性:各组的血常规、细胞形态、生化和相关酶学指标均在正常范围内。结论:无机活性元素骨组织工程支架材料有良好的成骨和再血管化功能,且生物相容性好,提示由该支架材料诱导的组织工程化骨构建有望成为临床骨组织大型缺损的替代材料。 | 叶茂昌 Chou L 王来平 李容新 陈梅梅 康然刚 周媛 白冰 龚飞飞 黄婕 周瑜 | 2007 | 中国组织工程研究与临床康复2007，11，48： | 4 |
| 2 | Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells 显示文摘 | Chou C C Pan S L Teng C M | 2003 | Eur J Pharm Sci2003，19，5： | 2 |
| 3 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 4 | Prevalence of Depression Among Elderly Chinese With Diabetes 显示文摘 | Chou KL Chi L | 2005 | Int J Geriatr Psychiatry2005，20，： | 1 |
| 5 | The fold of α-synuclein fibrils显示文摘 | Vilar M Chou HT Lührs T | 2008 | Proc Natl Acad Sci USA2008，105，25： | 1 |
| 6 | Direct observation of short-circuit diffusion during the formation of a single cupric oxide nanowire显示文摘 | Cheng C L Ma Y R Chou M H | 2007 | Nanotechnology2007，18，24： | 1 |
| 7 | Interval type-2 fuzzy neural network control for X-Y-Theta motion control stage using linear ultrasonic motors 显示文摘 | Faajeng L Syuanyi Chen Pohuan Chou | 2009 | Neurocomputing2009，72，46： | 1 |
| 8 | Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia显示文摘 | Hou H A Chou W C Lin L I | 2008 | Leuk Res2008，32，6： | 1 |
| 9 | Propofol alone versus propofol in combination with meperidine for sedation during colonoscopy显示文摘 | HSIEH Y H CHOU A L LAI Y Y | 2009 | J Clin Gastroenterol2009，43，7： | 1 |
| 10 | A comparative study of damage sensing in fiber composites using uniformly and non-uni- forrnly dispersed carbon nanotubes 显示文摘 | Gao L Chou T W Thostenson E T | 2010 | Carbon2010，48，13： | 1 |
| 11 | Effect of Tai Chi on depressive symptoms amongst Chinese older patients with depressive disorders:a randomized clinical trial显示文摘 | CHOU K L LEE P W YU E | 2004 | Int J Geriatr Psych2004，19，11： | 1 |
| 12 | Global causes of maternaldeath: a WHO systematic analysis显示文摘 | Say L Chou D Gemmill A | 2014 | Lancet Glob Health2014，2，6： | 1 |
| 13 | Environmental influence on coastal phytoplankton and zooplankton diversity:A multivariate statistical model analysis显示文摘 | Chou W R Fang L S Wang W H | 2012 | Environmental Monitoring and Assessment2012，184，9： | 1 |
| 14 | Reduced graphene oxide with superior cycling stability and rate capability for sodium storage显示文摘 | Wang Y X Chou S L Liu H K | 2013 | Carbon2013，57，： | 1 |
| 15 | A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal Cdk5 activator 显示文摘 | Chou K C Watenpaugh K D Heinrikson R L | 1999 | Biochem Biophys Res Commun1999，259，2： | 1 |
| 16 | Optimal dietary protein and lipid levels for juvenile cobia ( Rachycentron canadum)显示文摘 | Chou R L Su M S Chen H Y | 2001 | Aquaculture2001，193，： | 1 |
| 17 | Prosthetic survival and clinical results with use of large - segment replacements in the treatment of high grade bone sarcomas 显示文摘 | MALAWER M M CHOU L B | 1995 | J Bone Joint Surg1995，77，： | 1 |
| 18 | The Equilibrium Exchange Rate of the Chinese Renminbi 显示文摘 | Chou W L Shih Y C | 1998 | Journal of Comparative Economics1998，26，1： | 1 |
| 19 | Exchange Rate Variability and China' s Exports 显示文摘 | Chou W L | 2000 | Journal of Comparative Economics2000，，28： | 1 |
| 20 | Electrodeposition of MnO2 Nanowires on Carbon Nanotube Paper as Free-standing, Flexible Electrode for Supercapacitors 显示文摘 | Chou S L Wang J Z Chew S Y | 2008 | Electrochem Commun2008，10，11： | 1 |
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