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| 1 | 淋巴瘤中MYC蛋白的表达和MYC基因的重排情况显示文摘MYC易位是伯基特淋巴瘤( BL )和一组弥漫性大B细胞性淋巴瘤( DLBCL)的最典型特征,然而在淋巴瘤中仍未阐明MYC基因重排与临床关联,及其与MYC蛋白表达的相关性。采用组织微阵列技术,通过免疫组化法利用抗MYC单克隆抗体Y69和双重分离荧光原位杂交探针对1214个淋巴瘤进行MYC基因重排的检测。结果发现侵袭性B细胞淋巴瘤( BL和DLBCL)显示较高水平的MYC蛋白着色,大于50%的瘤细胞着色;很大一部分浆母细胞性淋巴瘤、B或T细胞淋巴母细胞性淋巴瘤和结外NK/T细胞性淋巴瘤显示大于50%的瘤细胞MYC蛋白着色,只有极少数的浆细胞骨髓瘤、套细胞淋巴瘤和经典的霍奇金淋巴瘤表现出较高水平的染色;当小B细胞性淋巴瘤中出现MYC蛋白着色时,小于50%的瘤细胞阳性。在侵袭性B细胞淋巴瘤中,MYC重排和MYC免疫组化显示较高的一致性,然而一些DLBCL和所有伴MYC蛋白表达的T细胞和NK细胞淋巴瘤却缺乏MYC基因的重排。本组结果指出MYC蛋白在淋巴瘤中的表达情况,并表明其表达并不特定于淋巴瘤亚型和细胞谱系,并与可预测的临床行为无关。另外,MYC蛋白的表达不一定与MYC基因重排有关,因此有必要高度谨慎说明MYC蛋白免疫组化在淋巴瘤鉴别诊断中的作用。 | Chisholm K M Bangs C D Bacchi C E 魏建国 刘勇 | 2015 | 临床与实验病理学杂志2015，31，5： | 8 |
| 2 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 3 | Comparison of reflux esophagitis and its complications between African Americans and non-Hispanic whites显示文摘AIM: To determine the effect of ethnicity on the severity of reflux esophagitis (RE) and its complications. METHODS: A retrospective search of the endoscopy database at the University of Florida Health Science Center/Jacksonville for all cases of reflux esophagitis and its complications from January 1 to March 31, 2001 was performed. Inclusion criteria were endoscopic evidence of esophagitis using the LA classif ication, reflux related complications and self-reported ethnicity. The data obtained included esophagitis grade, presence of a hiatal hernia, esophageal ulcer, stricture and Barrett's esophagus, and endoscopy indication. RESULTS: The search identified 259 patients with RE or its complications, of which 171 were non-Hispanic whites and 88 were African Americans. The mean ages and male/female ratios were similar in the two groups. RE grade, esophageal ulcer, stricture and hiatal hernia frequency were likewise similar in the groups. Barrett's esophagus was present more often in non-Hispanic whites than in African Americans (15.8% vs 4.5%; P < 0.01). Heartburn was a more frequent indication for endoscopy in non-Hispanic whites with erosive esophagitis than in African Americans (28.1% vs 7.9%; P < 0.001). CONCLUSION: Distribution of RE grade and frequency of reflux-related esophageal ulcer, stricture andhiatal hernia are similar in non-Hispanic whites and African Americans. Heartburn was more frequently and nausea/vomiting less frequently reported as the primary endoscopic indication in non-Hispanic whites compared with African Americans with erosive esophagitis or its complications. African Americans have a decreased prevalence of Barrett's esophagus compared with non-Hispanic whites. | Kenneth J Vega Sian Chisholm M Mazen Jamal | 2009 | World Journal of Gastroenterology2009，15，23： | 4 |
| 4 | Comparison of some French-American hybrid wines with white Riesling using gas chromatography-olfactometry显示文摘 | CHISHOLM MARY G GUIHER L ElSE A VONAH THERESE M | 1994 | The American Journal of Enology and Viticulture1994，45，2： | 1 |
| 5 | Urinary tissue factor levels in patients with bladder and prostate cancer显示文摘 | Lwaleed BA Francis JL Chisholm M | 2000 | Eur J Surg Oncol2000，26，： | 1 |
| 6 | Phytop]ankton population dynamics at the Bermuda Atlantic Time-Series station in the Sargasso Sea显示文摘 | DuRand M D Olson R J Chisholm S W | 2001 | Deep-Sea Res Pt II2001，48，： | 1 |
| 7 | Spectral discrimination of coral mortality states following a severe bleaching event 显示文摘 | CLARK C D MUMBY P J CHISHOLM J R M | 2000 | International Journal of Remote Sensing2000，21，11： | 1 |
| 8 | Reductive deehlorination of ehloroaeetanilide herbicide (alaehlor) using zero- valent iron nanopartieles 显示文摘 | Thompson J M Chisholm B J Bezbaruah A N | 2010 | Environmental Engineering Scienee2010，27，3： | 1 |
| 9 | Decoupled catalytic hydrogen evolution from a molecular metal oxide redox mediator in water splitting显示文摘 | Rausch B Symes M D Chisholm G Cronin L | 2014 | Science2014，345，6202： | 1 |
| 10 | Electrodeposition of thick chromium coating from an environmentally acceptable chromium (III) glycine complex 显示文摘 | EI-Sharif M Mcdougall J Chisholm C U | 1999 | Trans IMF1999，77，4： | 1 |
| 11 | Long- term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats 显示文摘 | Chalkley SM Hettiarachchi M Chisholm DJ | 2002 | Am J Pbysiol Endocrinol Metab2002，282，6： | 1 |
| 12 | Expulsion of dummy transmitters by rainbow trout 显示文摘 | Chisholm I M Hubert W A | 1985 | Trans Am Fish Soc1985，114，： | 1 |
| 13 | Impact of clinical pharmacy services on renal transplant patients' compliance with immunosuppressive medications显示文摘 | Chisholm MA Mulloy LL Jagadeesan M | 2001 | Clin Transplant2001，15，5： | 1 |
| 14 | Deepwater North West Borneo:Hydrocarbon accumulation in an active fold and thrust belt显示文摘 | Ingram G M Chisholm T J Grant C J | 2004 | Marine and Petroleum Geology2004，21，： | 1 |
| 15 | Characteristics of electro- deposited chromium显示文摘 | EI-Sharif M Chisholm C V | 1997 | Trans IMF1997，75，6： | 1 |
| 16 | Miliary tuberculosis in children: a review of 94 cases显示文摘 | Hussey G Chisholm T Kibel M | 1991 | Pediatr Infect Dis J1991，10，： | 1 |
| 17 | Strong Polarization Enhancement In Asymmetric Three-Com- ponent Ferroelectric Superlattices显示文摘 | Lee H N Christen H M Chisholm M F etal | 2005 | Nature2005，433，： | 1 |
| 18 | Trends in psychiatric- mental health nursing educationl显示文摘 | Delaney K Chisholm M Clement J | 1999 | Archives of Psychiatric Nurs- ing1999，13，： | 1 |
| 19 | Long- term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats 显示文摘 | Chalkley SM Hettiaraehchi M Chisholm DJ | 2002 | Am J Physiol Endocrinol Mebab2002，282，6： | 1 |
| 20 | Cobalt limitation and uptake in Prochlorococcus 显示文摘 | Saito M A Moffett J W Chisholm S W | 2002 | Limnology and Oceanography2002，47，： | 1 |
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