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| 1 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
| 2 | Profile Evolution and Energy Dissipation for Internal SolitonTransmitting over Different Submarine Ridges显示文摘Fundamental experiments were carried out in a wave flume on internal solitary wave (ISW) of depression-type propagating over a submerged ridge. The seabed ridge included either triangular or semicircular shape- regarded as topographic obstacles. Influenced by the submarine ridge, the transmitted waves were found to always consist of a leading pulse (a solitary wave) followed by a dispersive wave train. The wave profile propagating over a triangular ridge was similar to that caused by a semicircular obstacle. Apparently, the smooth face of a semicircular ridge produced time lag of wave propagation. From experimental results available, the reduction in wave energy induced by a semicircular ridge was larger than that by a triangular one. The events of wave distortion, strong breaking, internal bolus, and stratification mixing happened in case that the crest of an ISW was great enough to interact with the topographic obstacle. The reduction in wave energy was induced by strong breaking, and it depended on the ridge height rather than the geometric shape of the ridge. | Chen-Yuan CHEN I-Fan TSENG Hsien-Chueh Peter YANG Cheng-Wu CHEN Tsung-Hao CHENe | 2006 | China Ocean Engineering2006，20，4： | 2 |
| 3 | HLA 2DRB and 2DQB alle contribution to narcolep sy suscep tibility in Chinese patients with narcolep sy显示文摘 | Han F Chene Z Weih L | 2003 | Natl Med J Chinam2003，83，： | 1 |
| 4 | Gene expression profiling in clinically localized prostate cancer:a four-gene expression model predicts clinical behavior显示文摘 | Latil A Bieche I Chene L | 2003 | Clin Cancer Res2003，，15： | 1 |
| 5 | High-temperature behavior of HPC with polypropene fibres,from spalling to min-constructure显示文摘 | Pierrre Kalifa Gregoire Chene Christophe Galle | 2001 | Cement and Concrete Research2001，，31： | 1 |
| 6 | High-temperature behavior of HPC with polypropylene fibres from spalling to microstructure 显示文摘 | Pierre Kalifa Gregoire Chene Christophe Galle | 2001 | Cement and Concrete Research2001，31，： | 1 |
| 7 | Is guanxi orientation bad ethically speaking? A study of Chinese enterprise 显示文摘 | Chening Su M J Sirgy J E Littefield | 2003 | Journal of business ethics2003，，44： | 1 |
| 8 | Recent developments and potentialities for reducing embryo mortality in ruminauts: the role of IFN - tau and other cytokines in early pregnancy 显示文摘 | Martal J Chene C Camons S | 1997 | Reprod Fertil Dev1997，9，3： | 1 |
| 9 | Quantification of expression of netrins,slits and their receptors in human prostate tumors显示文摘 | CHENE L COCHANT-PRIOLLET B | 2003 | Int J Cancer2003，103，3： | 1 |
| 10 | Prognosis of HIV-1 infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies 显示文摘 | Egger M May M Chene G | 2002 | Lancet2002，360，： | 1 |
| 11 | Prognosis of HIV-l-infected patients starting highly active antiretroviral therapy : acollaborative analysis of prospective studies 显示文摘 | Egger M May M Chene G | 2002 | Lancet2002，360，9327： | 1 |
| 12 | Hydrogen Embrittlement of the Ni-base Alloy 600 Correlated with Hydrogen Transport by Dislocations显示文摘 | Lecoester F Chene J Noel D | 1999 | Materials Science and Engineering1999，262，： | 1 |
| 13 | Comparative of TGF- α and EGF genes in the ovine conceptus and utrine endometrium in the peri - implantation period显示文摘 | Chene N Martal J | 1995 | Repord Nutr Dev1995，35，： | 1 |
| 14 | High - temperature behaviour ofHPC with polypropylene fibres from spalling to microstructure 显示文摘 | KALIFAP CHENE G GALLE C | 2001 | Cement and Concrete Research2001，31，10： | 1 |
| 15 | Effect of acute Plasmodiumfalciparum malaria on reactivation and shedding of the eight hu-man herpes viruses显示文摘 | Chene A Nylen S Donati D | 2011 | PLoS One2011，6，26： | 1 |
| 16 | Plasmin Acfvity in Milk显示文摘 | KORYCKA-DAHL M RLBADEAU DUMAS B CHENE N | 1983 | J Dairy Sci1983，66，： | 1 |
| 17 | Prognosis of HIV - 1 - infectedpatients starting highly active antiretroviral therapy : a collaborative a-nalysis of prospective studies 显示文摘 | Egger M May M Chene G | 2002 | Lancet2002，360，： | 1 |
| 18 | A small synthetic peptide, Which in-hibits the p53 - hdm2interaction, stimuates the p53 Pathway in tumourcell lines显示文摘 | Chene P Fuchs J Bohn J | 2000 | Mol Biol2000，299，1： | 1 |
| 19 | HIV infected adults with a CD4 cell count greater than 500 cells/rnm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population显示文摘 | Lewden C Chene G Morlat P | 2007 | J Acquir Immune Defic Syndr2007，46，1： | 1 |
| 20 | Optimized expression of Plasmodium falciparum erythrocyte membrane protein 1 do- mains in Escherichia coli 显示文摘 | Flick K Ahuja S Chene A | 2004 | Malaria Journal2004，3，1： | 1 |
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