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| 1 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 2 | Review of primary sclerosing cholangitis with increased IgG4 levels显示文摘Primary sclerosing cholangitis(PSC) is a chronic progressive liver disease. Subtypes of PSC have been described, most recently PSC with elevated serum and/or tissue IgG4 subclass. We aim to summarise the clinical phenotype,disease associations, differential diagnosis, response to therapy and pathogenic mechanisms underlying PSC-high IgG4 subtype. We reviewed Pub Med,MEDLINE and Embase with the search terms 'primary sclerosing cholangitis','IgG4', and 'IgG4-related sclerosing cholangitis(IgG4-SC)'. Elevated serum IgG4 are found in up-to one-quarter, and abundant IgG4-plasma cell infiltrates in the liver and bile ducts are found in up-to one-fifth of PSC patients. This group have a distinct clinical phenotype, with some studies reporting a more aggressive course of liver and associated inflammatory bowel disease, compared to PSCnormal IgG4 and the disease mimic IgG4-SC. Distinguishing PSC-high IgG4 from IgG4-SC remains challenging, requiring careful assessment of clinical features,organ involvement and tissue morphology. Calculation of serum IgG4:IgG1 ratios and use of a novel IgG4:IgG RNA ratio have been reported to have excellent specificity to distinguish IgG4-SC and PSC-high IgG4 but require validation in larger cohorts. A role for corticosteroid therapy in PSC-high IgG4 remains unanswered, with concerns of increased toxicity and lack of outcome data. The immunological drivers underlying prominent IgG4 antibodies in PSC are incompletely defined. An association with PSC-high IgG4 and HLA class-II haplotypes(B*07, DRB1*15), T-helper2 and T-regulatory cytokines(IL4, IL10,IL13) and chemokines(CCL1, CCR8) have been described. PSC-high IgG4 have a distinct clinical phenotype and need careful discrimination from IgG4-SC,although response to immunosuppressive treatments and long-term outcome remains unresolved. The presence of IgG4 likely represents chronic activation to persistent antigenic exposure in genetically predisposed individuals. | Charis D Manganis Roger W Chapman Emma L Culver | 2020 | World Journal of Gastroenterology2020，26，23： | 5 |
| 3 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 4 | Morphological changes in the skin and wool fibres of Merino sheep infused with mouse epidermal growth factor 显示文摘 | Hollis D E Chapman R E Panaretto B A | 1983 | Aust J Biol Sci1983，36，4： | 1 |
| 5 | Reflected Blast Wave Resultants Behind Cantilever Walls:A New Prediction Technique 显示文摘 | CHAPMAN T C ROSE T A SMITHS P D | 1995 | International Journal of Impact Engineering1995，16，3： | 1 |
| 6 | Drug resistance in avian coccidian a review Vet显示文摘 | Chapman H D | 1984 | Parasitol1984，15，： | 1 |
| 7 | Construction of random small-insert genomic libraries highly enriched for simple sequence repeats显示文摘 | KARAGYZOV L KALCHIEVA I D CHAPMAN V M | 1993 | Nucleic Acids Re-search1993，21，16： | 1 |
| 8 | Zn and Cu isotopic variability in the Alexan- drinka volcanic-hosted massive sulphide (VHMS) ore deposit,Urals,Russia显示文摘 | MASON T F D WEISS D J CHAPMAN J B | 2005 | Chemical Geology2005，221，34： | 1 |
| 9 | Biochemical,genetic and applied aspects of drug resistance in Eimeria parasites of the fowl显示文摘 | Chapman D M | 1997 | Avian Pathol1997，26，： | 1 |
| 10 | Drug Evaluations Using Neuronal Networks Cultured on Microelectrode Arrays显示文摘 | Morefield S I Keefer E W Chapman K D | 2000 | Biosensors & Bioelectronics2000，15，： | 1 |
| 11 | Human breast cancer specimens:diffraction-enhanced imaging with histologic correlation-improved conspicuity of lesion detail compared with digital radiography显示文摘 | Pisano E D Johnston R E Chapman D | 2000 | Radiology2000，214，3： | 1 |
| 12 | Individual variation in response to altitude training显示文摘 | Chapman R F Stray-Gundersen J Levine B D | 1998 | J Appl Physiol1998，85，4： | 1 |
| 13 | Thermal gradients in the continental crust显示文摘 | Chapman D S | 1986 | Geol Soc Spec Publ1986，24，1： | 1 |
| 14 | Thermal histories and hydrocarbon generation: Example from Utah-Wyoming thrust belt 显示文摘 | Deming D Chapman D S | 1989 | AAPG Bulletin1989，73，12： | 1 |
| 15 | 显示文摘 | Abouimrane A Dambournet D Chapman K W | 2012 | J Am Chem Soc2012，134，10： | 1 |
| 16 | Treatment of esopha- geal cancer based on histology: a surveillance epidemiology and end results analysis 显示文摘 | Chang D T Chapman C Shen J | 2009 | American Journal of Clinical Oncolo- gy2009，32，4： | 1 |
| 17 | A Contribution to the theory of electro- capillarity显示文摘 | Chapman D L | 1913 | Philosophical Magazine1913，25，： | 1 |
| 18 | Human breast cancer specimens:diffraction-enhanced imaging with histologic correlation-improved conspicuity of lesion detail compared with digital radiography显示文摘 | Johnston RE Chapman D | 2000 | Radiology2000，214，3： | 1 |
| 19 | Sensitivity of field isolates of Eimeria from two broiler complexes to anticoccidial drugs in the chicken显示文摘 | Chapman H D Shirley M W | 1994 | Poultry Science1994，73，： | 1 |
| 20 | Biomembrane surfaces as models for polymer design- the potential for haemocompatibility显示文摘 | Hayward J A Chapman D | 1984 | Biomaterials1984，，5： | 1 |
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