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| 1 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 2 | The u-Lagrangian of a Convex Function显示文摘 | F Oustry C Sagastizábal | 2000 | Transactions of the American Mathematical Society2000，352，： | 1 |
| 3 | Ion-exchange Fractionation of Copper and Zinc Isotopes显示文摘 | Chloé Maréchal Francis Albaréde | 2002 | Geochimica et Cosmochimica Acta2002，66，： | 1 |
| 4 | Copy number variations in chronic pancreatitis显示文摘 | Chen J M Masson E Le Maréchal C Férec C | 2009 | Cytogenetic and Genome Research (-)2009，，1： | 1 |
| 5 | Localization of hepatitis B surface antigen epitopes present on variants and specifically recognised by anti-hepatitis B surface antigen monoclonal antibodies显示文摘 | Jolivet-Reynaud C Lésenéchal M O'Donnell B | | 0，，02： | 1 |
| 6 | Mitral repair versus replacement for ischemic mitral regurgitation:comparison of short-term and long-term survival显示文摘 | MAGNE J GIRERD N SéNéCHAL M | 2009 | Circulation2009，120，11： | 1 |
| 7 | Convergence of some algorithms for convex minimization显示文摘 | Rafael Correa Claude Lemaréchal | 1993 | Mathematical Programming (-)1993，，1： | 1 |
| 8 | The显示文摘 | Kube Sebastian Clemens Puppe Michel Maréchal | | 0，，： | 1 |
| 9 | Evaluation of two strategies(initial methotrexate monotherapy vs its combination with adalimum-ab)in management of early active rheumatoid arthritis:data from theGUEPARD trial显示文摘 | Soubrier M Puéchal X Sibilia J | 2009 | Rheumatology(Oxford)2009，48，11： | 1 |
| 10 | Purification and Comparative Properties of the Cytosolic Isocitrate Dehydrogenases (NADP) from Pea (Pisum sativunz)Roots and Green Leaves显示文摘 | CHEN R D MAR(E)CHAL P L VIDAL J | 1988 | Eur J Biochem1988，175，： | 1 |
| 11 | Precise analysis of copper and zinc isotopic compositions by plasma-source mass spectrometry显示文摘 | Maréchal C N Télouk P Albarède F | 1999 | Chem Geol1999，156，14： | 1 |
| 12 | Precise analysis of copper and zinc isotopic compositions by plasma-source mass spectrometry显示文摘 | Maréchal C N Télouk P Albarede F | 1999 | Chem Geol1999，156，： | 1 |
| 13 | Peripheral arterial disease in diabetic and nondiabetic patients:a comparison of severity outcome显示文摘 | Jude EB Oyibo SO Chal mer N | 2001 | Diabetes Care2001，24，： | 1 |
| 14 | Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of fracture and need for parathyrOidectomy in CKD显示文摘 | Goldsmith D Kothawala P Chal Jan A | 2009 | Am J Kidney Dis2009，53，： | 1 |
| 15 | Peripheral Arterial Disease in Diabetic and Nondiabetic Patients: a Comparison of Severity Outcome显示文摘 | Jude E B Oyibo S O Chal Mer N | 2001 | Diabetes Care2001，24，： | 1 |
| 16 | -hydrogenase cyanide ligands derived from S-adenosy- lmethionine-dependent cleavage of tyrosine显示文摘 | Driesener R C Chal McGlynn S E | 2010 | Angewandte Chemie2010，49，9： | 1 |
| 17 | Evaluation of two strategies(initial methotrexate monotherapy vs its combination with adalimumab)in management of early active rheumatoid arthritis:data from the GUEPARD trial显示文摘 | Soubrier M Pnéchal X Sibilia J | 2009 | Rheumatology(Oxford)2009，48，： | 1 |
| 18 | Role of TYF-1,CK20,and CK7 immunohistochemistry for diagnosis of primary and secondary lung adenocarcinoma显示文摘 | Su YC Hsu YC Chal CY | | 0，，01： | 1 |
| 19 | The tomato factor Pti4 regulates defense-related genes expression via GCC box and non-GCC box cis elements 显示文摘 | Chal Qavarthy S Tuori R P D'Ascenzo M D | 2003 | Plant Cell2003，15，12： | 1 |
| 20 | Long-term outcomes of 118 patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) enrolled in two prospective trials显示文摘 | Samson M Puéchal X Devilliers H | | 0，，： | 1 |
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