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| 1 | Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells显示文摘AIM: To study whether indomethacin (IND), a nonselective cyclooxygenase (COX) inhibitor or NS-398 (NS), a COX-2-selective inhibitor, induces apoptosis in human colon cancer cells and which apoptosis-related genes and pathways are involved. METHODS: Human colon cancer Caco-2 cells were treated with either: placebo, IND (0.05-0.5 mmol/L) or NS (0.01-0.2 mmol/L) for 1, 5 and 18 h. We then studied: (1) Cell death by the TUNEL method, (2) mRNA expression of 96 apoptosis-related genes using DNA microarray, (3) expression of selected apoptosis related proteins by Western blotting. RESULTS: Both IND and NS induced apoptosis in 30%-50% of Caco-2 cells in a dose dependent manner. IND (0.1 mmol/L for 1 h) significantly up-regulated pro-apoptotic genes in four families: (1) TNF receptor and ligand, (2) Caspase, (3) Bcl-2 and (4) Caspase recruiting domain. NS treatment up-regulated similar pro-apoptotic genes as IND. In addition, IND also down-regulated anti-apoptotic genes of the IAP family. CONCLUSION: (1) Both non-selective and COX-2-selective NSAIDs induce apoptosis in colon cancer cells in a dose dependent manner. (2) Both NSAIDs induce apoptosis by activating two main apoptotic pathways: the death receptor pathway (involving TNF-R) and the mitochondrial pathway. (3) IND induces apoptosis by up-regulating pro-apoptotic genes and down-regulating anti-apoptotic genes, while NS only up-regulates pro-apoptotic genes. (4) Induction of apoptosis in coloncancer cells by NSAIDs may explain in part, their inhibitory action on colon cancer growth. | Richard H Huang Jianyuan Chai Andrzej S Tarnawski | 2006 | World Journal of Gastroenterology2006，12，40： | 11 |
| 2 | Fuzzy adaptive control for a class of nonlinear systems显示文摘 | TONG S C CHAI T Y | 1999 | Fuzzy Sets and Systems1999，10，2： | 2 |
| 3 | Fuzzy direct adaptive control for a class of nonlinear systems显示文摘 | CHAI T Y TONG S C | 1999 | Fuzzy Sets and Systems1999，103，3： | 2 |
| 4 | A NEW SERIES OF NONLINEAR OPTICAL ORGANIC MATERIALS WITH MOLECULAR RECEPTOR - DESIGN AND SYNTHESIS显示文摘 | Cao Y Chen S Chai X | | 0，，： | 2 |
| 5 | 查看详情显示文摘 | Peng X G Guan S Q Chai X D | | 0，，： | 2 |
| 6 | 显示文摘 | Tan S Hang C Chai J | 1997 | Automatica1997，33，3： | 1 |
| 7 | A relative difference quotient algorithm for discrete optimization显示文摘 | Chai S Sun H C | 1996 | Struc Optim1996，12，1： | 1 |
| 8 | Research on environmental-friendly anodizing process for magnesium alloys显示文摘 | LUO S L DAI L ZHOU H H CHAI L Y KUANG Y F | 2005 | Journal of Hunan University (Natural Sciences)2005，32，3： | 1 |
| 9 | Intelligent deeoupling control of power plant main steam pressure and powe't output 显示文摘 | Liu H B Li S Y Chai T Y | 2003 | International Journal of Electrical Power and Energy System2003，25，10： | 1 |
| 10 | Role of murine intestinal intraepithelial lymphocytes and lamina propria lymphocytes against primary and challenge infections with Cryptosporidium parvum显示文摘 | Guk S Yong TS Chai JY | 2003 | The Journal of Parasitology2003，89，2： | 1 |
| 11 | Bioactive nanocrystalline sol-gel hydroxyapatite coatings显示文摘 | CHAI C S BEN NISSAN B | 1999 | Journal of Materials Science: Materi als in Medicine1999，10，8： | 1 |
| 12 | A randomized trial to compare two dosing intervals of misoprostol following mifepristone administration in second trimester medical a- bortion 显示文摘 | Chai J Tang 0 S Hong Q Q | 2009 | Hum Reprod2009，24，2： | 1 |
| 13 | Optimization ofmultiplex PCR conditions for rapid detection of Escherichia coli O157:H7 virulence genes 显示文摘 | Jeshveen S S Chai L C Pui C F | 2012 | International Food Reseach Journal2012，19，2： | 1 |
| 14 | Effect of near-fauh vertical ground motions on seismic response of highway overcrossings 显示文摘 | Kunnath S K Erduran E Chai Y H | 2008 | Bridge Engineering2008，13，3： | 1 |
| 15 | Prognostic factors of green pit viper bites显示文摘 | ROJNUCKARIN P MAHASANDANA S INTRAGUMTHORN- CHAI T | 1998 | Am J Trip Med Hyg1998，58，1： | 1 |
| 16 | Immunoadhesins containing pre-S domains of hepatitis B virus large envelope protein are se- creted and in hibit virus infection 显示文摘 | Chai N Gudima S Chang J | 2007 | J Virol2007，81，10： | 1 |
| 17 | Ultimate shear strength of long web panels 显示文摘 | Sung C Lee Doo S Lee Chai H Yoo | 2008 | Journal of Constructional Steel Research2008，64，： | 1 |
| 18 | Internet and online information privacy: An exploratory study of preteens and early teens显示文摘 | Chai S Bagchi-Sen S Morrell C | 2009 | Pro- fessional Communication IEEE Transactions on2009，52，2： | 1 |
| 19 | Synthesis and characterization of graphene and carbon nanotubes:A review on the past and recent developments 显示文摘 | Liu W W Chai S P Mohamed A R | 2014 | Journal of Industrial and Engineering Chemistry2014，20，： | 1 |
| 20 | Effect of Near-Fault Vertical Ground Motions on Seismic Re sponse of Highway Overcrossings 显示文摘 | Kunnath S K Erduran E Chai Y H | 2008 | Journal of Bridge Engineering2008，13，3： | 1 |
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