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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions显示文摘 | Silvina G. Castro Sergio F. Sanchez Bruni Lucí a P. Urbizu Alejandra Confalonieri Laura Ceballos Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2013 | Pharmaceutical Development and Technology2013，，2： | 2 |
| 3 | Homocysteine,oxidative Stress,and endothelium function in uremic patients显示文摘 | Massy ZA Ceballos I Chadefaux-Vekemens B | 2001 | Kideny Int Suppi2001，78，： | 2 |
| 4 | Homocysteine, oxidative stress, and endothelium function in uremic patients显示文摘 | Massy ZA Ceballos I Chadefaux-Vekemens B | 2001 | Kidney Int2001，78，： | 1 |
| 5 | Histamine improves anti-gen uptake and cross-presentation by dendritic cells 显示文摘 | Amaral M M Davio C Ceballos A | 2007 | J Immu-nol2007，179，6： | 1 |
| 6 | A carrier-based PWM strategy with zero-sequence voltage injection for a three-level neutral-point-clamped converter显示文摘 | Pou J Zaragoza J Ceballos S | 2012 | IEEE Transactions on Power Electronics2012，27，2： | 1 |
| 7 | Dam reservoir eutrophication:A simplified technique for a fast diagnosis of envimnmental degradation 显示文摘 | CEBALLOS R S KONG A OLIVERRA J F | 1998 | Water Res1998，32，： | 1 |
| 8 | Consensus statement on bladder injuries显示文摘 | Gomez RG Ceballos L Coburn M | 2004 | BJU International2004，94，1： | 1 |
| 9 | Is anti-h-caldesmon usefull for distinguishing smooth muscle and myofibroblastie tu- mors?An immuonhistochemical study 显示文摘 | Ceballos KM Nielsen GP Selig MK | 2000 | Am J Clin Pathol2000，114，5： | 1 |
| 10 | Discoveries of new mammal species and their implications for conservation and ecosystem services显示文摘 | Ceballos G Ehrlich PR | 2009 | Proc Natl Acad Sci2009，106，10： | 1 |
| 11 | Fengycin C produced by Bacillus subtilis EA-CB0015显示文摘 | Villegas-Escobar V Ceballos I Mira J J | 2013 | Journal of Natural Products2013，76，4： | 1 |
| 12 | Reduction of ischemic dsmage in NGF-transgenic mice:Correlation with enhancement of antiosidant enzyme activeties显示文摘 | Guegan C Ceballos Picot 1 Chebalier E | 1999 | Neurobiol Dis1999，6，3： | 1 |
| 13 | Brain meturation in conduct disordoer versus borderline peronality disorder显示文摘 | Ceballos NA Houston R J Hesselbrock WM | 2006 | Neuropsychobiology2006，53，2： | 1 |
| 14 | North Pacific gyre oscillation synchronizes climate fluctuations in the eastern and western boundarysystems显示文摘 | CEBALLOS L DI LORENZO E HOYOS C D | 2009 | Journal of Climate2009，22，19： | 1 |
| 15 | The Future of Ecotourism 显示文摘 | Ceballos Lascurain H | 1987 | Mexico Journal1987，，2： | 1 |
| 16 | The future of ecotourism 显示文摘 | Ceballos L H | 1987 | Mexico Journal1987，，1： | 1 |
| 17 | Red cell distribution width(RDW) :its use in the characterization of microcytic and hypochromic anemias 显示文摘 | Romero Aj Carbia CD Ceballo MF | 1999 | Medicina ( B Aires)1999，59，1： | 1 |
| 18 | Interactive effects of ertension and alcohol dependence on the P300 eventrelated potential in AfricanAmericans显示文摘 | Bauer LO Ceballos NA Taylor RE | 2006 | Clin EEG Neurosci2006，37，： | 1 |
| 19 | Determination of the axial 'force on stay cables accounting for their bending stiffness and rotational end restraints by free vibration tests 显示文摘 | CEBALLOS M A PRATO C A | 2008 | Journal of Sound and Vibration2008，317，4： | 1 |
| 20 | A role for antimicrobial peptides in in- testinal microsporidiosis 显示文摘 | Leitch GJ Ceballos C | 2009 | Parasitology2009，136，： | 1 |
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