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| 1 | Diagnostic strategy for occult hepatitis B virus infection显示文摘In 2008,the European Association for the study of the liver(EASL) defined occult hepatitis B virus infection (OBI) as the'presence of hepatitis B virus(HBV) DNA in the liver(with detectable or undetectable HBV DNA in the serum) of individuals testing hepatitis B surface antigen(HBsAg) negative by currently available assays'.Several aspects of occult HBV infection are still poorly understood,including the definition itself and a standardized approach for laboratory-based detection,which is the purpose of this review.The clinical significance of OBI has not yet been established;however,in terms of public health,the clinical importance arises from the risk of HBV transmission.Consequently,it is important to detect high-risk groups for occult HBV infection to prevent transmission.The main issue is,perhaps,to identify the target population for screening OBI.Viremia is very low or undetectable in occult HBV infection,even when the most sensitive methods are used,and the detection of the viral DNA reservoir in hepatocytes would provide the best evaluation of occult HBV prevalence in a defined set of patients.However,this diagnostic approach is obviously unsuitable:blood detection of occult hepatitis B requires assays of the highest sensitivity and specificity with a lower limit of detection<10 IU/mL for HBV DNA and<0.1 ng/mL for HBsAg. | Sara Ocana Maria Luisa Casas Ingrid Buhigas Jose Luis Lledo | 2011 | World Journal of Gastroenterology2011，17，12： | 16 |
| 2 | Myocardial infarction with non-obstructive coronary arteries: A comprehensive review and future research directions显示文摘Acute coronary syndromes constitute a variety of myocardial injury presentations that include a subset of patients presenting with myocardial infarction with non-obstructive coronary arteries(MINOCA).This acute coronary syndrome differs from type 1 myocardial infarction(MI)regarding patient characteristics,presentation,physiopathology,management,treatment,and prognosis.Two-thirds of MINOCA subjects present ST-segment elevation;MINOCA patients are younger,are more often female and tend to have fewer cardiovascular risk factors.Moreover,MINOCA is a working diagnosis,and defining the aetiologic mechanism is relevant because it affects patient care and prognosis.In the absence of relevant coronary artery disease,myocardial ischaemia might be triggered by an acute event in epicardial coronary arteries,coronary microcirculation,or both.Epicardial causes of MINOCA include coronary plaque disruption,coronary dissection,and coronary spasm.Microvascular MINOCA mechanisms involve microvascular coronary spasm,takotsubo syndrome(TTS),myocarditis,and coronary thromboembolism.Coronary angiography with non-significant coronary stenosis and left ventriculography are first-line tests in the differential study of MINOCA patients.The diagnostic arsenal includes invasive and non-invasive techniques.Medical history and echocardiography can help indicate vasospasm or thrombosis,if one finite coronary territory is affected,or specify TTS if apical ballooning is present.Intravascular ultrasound,optical coherence tomography,and provocative testing are encouraged.Cardiac magnetic resonance is a cornerstone in myocarditis diagnosis.MINOCA is not a benign diagnosis,and its polymorphic forms differ in prognosis.MINOCA care varies across centres,and future multi-centre clinical trials with standardized criteria may have a positive impact on defining optimal cardiovascular care for MINOCA patients. | Rafael Vidal-Perez Charigan Abou Jokh Casas Rosa Maria Agra-Bermejo Belén Alvarez-Alvarez Julia Grapsa Ricardo Fontes-Carvalho Pedro Rigueiro Veloso Jose Maria Garcia Acuña Jose Ramon Gonzalez-Juanatey | 2019 | World Journal of Cardiology2019，11，12： | 6 |
| 3 | Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: An Italian experience显示文摘AIM: To evaluate endoscopic mucosal resection (EMR)in patients with high-grade dysplasia (HGD) and/or intramucosal cancer (IMC) in Barrett's esophagus (BE).METHODS: Between June 2000 and December 2003,39 consecutive patients with HGD (35) and/or IMC (4)underwent EMR. BE >30 mm was present in 27 patients.In three patients with short segment BE (25.0%), HGDwas detected in a normal appearing BE. Lesions had a mean diameter of 14.8±10.3 mm. Mucosal resection was carried out using the cap method.RESULTS: The average size of resections was 19.7±9.4×14.6±8.2 mm. Histopathologic assessment postresection revealed 5 low-grade dysplasia (LGD) (12.8%),27 HGD (69.2%), 2 IMC (5.1%), and 5 SMC (-12.8%).EMR changed the pre-treatment diagnosis in 10 patients (25.6%). Three patients with SMC underwehtsurgery.Histology of the surgical specimen revealed 1 T0N0 and 2 T1N0 lesions. The remaining two patients were cancer free at 32.5 and 45.6 mo, respectively. A metachronous lesion was detected after 25 mo in one patient with HGD. Intra-procedural bleeding, controlled at endoscopy,occurred in four patients (10.3%). After a median followup of 34.9 mo, all patients remained in remission.CONCLUSION: In the medium term, EMR is effective and safe to treat HGD and/or IMC within BE and is a valuable staging method. It could become an alternative to surgery. | Massimo Conio Alessandro Repici Renzo Cestari Sabrina Blanchi Gabriella Lapertosa Guido Missale Domenico Della Casa Vincenzo Villanacci Pier Gigi Calandri Rosangela Filiberti | 2005 | World Journal of Gastroenterology2005，11，42： | 6 |
| 4 | 万古霉素最低抑菌浓度对甲氧西林敏感金黄色葡萄球菌心内膜炎预后的影响显示文摘金黄色葡萄球菌(金葡菌)引起的心内膜炎病死率高。万古霉素最低抑菌浓度(MIC )能影响耐甲氧西林金葡菌所致血流感染的结果,最近的数据显示,其对甲氧西林敏感金葡菌也有类似作用。本文目的是评价万古霉素M IC对氯唑西林治疗的左心金葡菌感染性心内膜炎疗效的影响。 | Cervera C Casaeda X de la Maria CG 范亚新 张菁 | 2015 | 中国感染与化疗杂志2015，15，3： | 4 |
| 5 | Nutritional value of high fiber co-products from the copra,palm kernel,and rice industries in diets fed to pigs显示文摘High fiber co-products from the copra and palm kernel industries are by-products of the production of coconut oil and palm kernel oil. The co-products include copra meal, copra expellers, palm kernel meal, and palm kernel expellers. All 4 ingredients are very high in fiber and the energy value is relatively low when fed to pigs. The protein concentration is between 14 and 22 % and the protein has a low biological value and a very high Arg:Lys ratio. Digestibility of most amino acids is less than in soybean meal but close to that in corn. However, the digestibility of Lys is sometimes low due to Maillard reactions that are initiated due to overheating during drying.Copra and palm kernel ingredients contain 0.5 to 0.6 % P. Most of the P in palm kernel meal and palm kernel expellers is bound to phytate, but in copra products less than one third of the P is bound to phytate. The digestibility of P is, therefore, greater in copra meal and copra expellers than in palm kernel ingredients. Inclusion of copra meal should be less than 15 % in diets fed to weanling pigs and less than 25 % in diets for growing-finishing pigs. Palm kernel meal may be included by 15 % in diets for weanling pigs and 25 % in diets for growing and finishing pigs.Rice bran contains the pericarp and aleurone layers of brown rice that is removed before polished rice is produced.Rice bran contains approximately 25 % neutral detergent fiber and 25 to 30 % starch. Rice bran has a greater concentration of P than most other plant ingredients, but 75 to 90 % of the P is bound in phytate. Inclusion of microbial phytase in the diets is, therefore, necessary if rice bran is used. Rice bran may contain 15 to 24 % fat, but it may also have been defatted in which case the fat concentration is less than 5 %. Concentrations of digestible energy(DE) and metabolizable energy(ME) are slightly less in full fat rice bran than in corn, but defatted rice bran contains less than 75 % of the DE and ME in corn. The concentration of crude protein is 15 to 18 % in rice bran and the protein has a high biological value and most amino acids are well digested by pigs. Inclusion of rice bran in diets fed to pigs has yielded variable results and based on current research it is recommended that inclusion levels are less than 25 to 30 % in diets for growing-finishing pigs, and less than 20 % in diets for weanling pigs.However, there is a need for additional research to determine the inclusion rates that may be used for both full fat and defatted rice bran. | Hans Henrik Stein Gloria Amparo Casas Jerubella Jerusalem Abelilla Yanhong Liu Rommel Casilda Sulabo | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 3 |
| 6 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 7 | Influence of occult hepatitis B virus infection in chronic hepatitis C outcomes显示文摘Persistence of hepatitis B virus-DNA in the sera,peripheral blood mononuclear cells or in the liver of hepatitis B surface antigen(HBsAg) -negative patients with or without serological markers of previous exposure(antibodies to HBsAg and/or to HB-core antigen) defines the entity called occult hepatitis B infection(OBI).Co-infection with hepatitis B and hepatitis C viruses is frequent in highly endemic areas.While this co-infection increases the risk of liver disease progression,development of cirrhosis and hepatocellular carcinoma and also increases the rate of therapeutic failure to interferon-based treatments than either virus alone,a potentially negative effect of OBI on clinical outcomes and of therapeutic response to current antiviral regimes of patients with chronic hepatitis C remains inconclusive. | Conrado M Fernandez-Rodriguez Maria Luisa Gutierrez JoséLuis Lledó Maria Luisa Casas | 2011 | World Journal of Gastroenterology2011，17，12： | 3 |
| 8 | Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus显示文摘 | J.L. Casas López J.A. Sánchez Pérez J.M. Fernández Sevilla E.M. Rodríguez Porcel Y. Chisti | 2004 | Journal of Biotechnology2004，，1： | 2 |
| 9 | Evaluation and Exploitation of Retrieval Algorithms for Estimating Biophysical Crop Variables Using Sentinel-2,Venus,and PRISMA Satellite Data显示文摘This paper is devoted to the development and testing of the optimal procedures for retrieving biophysical crop variables by exploiting the spectral information of current multispectral optical satellite Sentinel-2 and Venus and in view of the advent of the new Sino-EU hyperspectral satellite(e.g.,PRISMA,EnMAP,and GF-5).Two different methodologies devoted to the estimation of biophysical crop variables Leaf area index(LAI)and Leaf chlorophyll content(Cab)were evaluated:non-kernel-based and kernel-based Machine Learning Regression Algorithms(MLRA);Sentinel-2 and Venus data comparison for the analysis of the durum wheat-growing season.Results show that for Sentinel-2 data,Gaussian Process Regression(GPR)was the best performing algorithm for both LAI(R 2=0.89 and RMSE=0.59)and Cab(R 2=0.70 and RMSE=8.31).Whereas,for PRISMA simulated data the Kernel Ridge Regression(KRR)was the best performing algorithm among all the other MLRA(R 2=0.91 and RMSE=0.51)for LAI and(R 2=0.83 and RMSE=6.09)for Cab,respectively.Results of Sentinel-2 and Venus data for durum wheat-growing season were consistent with ground truth data and confirm also that SWIR bands,which are used as tie-points in the PROSAIL inversion,are extremely useful for an accurate retrieving of crop biophysical parameters. | Raffaele CASA Deepak UPRETI Angelo PALOMBO Simone PASCUCCI Hao YANG Guijun YANG Wenjiang HUANG Stefano PIGNATTI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 10 | 西南极利文斯顿岛汉那角火山岩地质及火山活动显示文摘本文以野外地质资料为基础,并结合岩相学特征,论述了西南极南设得兰群岛利文斯顿岛汉那角(HannahPoint)火山岩地层及岩石的基本特征,初步讨论了该地火山活动过程。该地互层状产出的火山角砾岩和熔岩,为南极半岛火山岩组的一部分。剖面上出露的三个火山岩地层旋回分别是三期火山作用的产物。第一、二旋回岩层产状的变化记录了火山作用过程中的一次活动间歇。第一旋回的英安岩和含有流纹岩质熔岩夹层的凝灰角砾岩仅为第一期火山活动末的产物;第二旋回为三次较强喷发活动的产物,从安山岩质火山碎屑岩为主,经玄武岩-安山岩质熔岩为主,过渡为含有安山岩或流纹岩质熔浆团的火山角砾岩。第三期火山活动可能更强烈,大面积分布的厚层玄武质熔岩无论从产状上还是在岩石学特征方面都有别于其他旋回。火山岩地层总体产状稳定,平缓地倾向北西,表明该区未受到过明显的构造影响,火山活动中心可能有逐步向北西迁移的趋势,与南设得兰群岛岩浆弧演变趋势一致。次火山岩主要为玄武岩质小岩墙,集中在第二旋回底部。第一、二旋回接触界线两侧凝灰角砾岩表现较强的沸石化。这些现象说明该接触面附近为一薄弱带,侵入活动和蚀变均较易发生。 | 郑祥身 Francesc Sabat Josep M Casas Ranimon Pallas | 1994 | 南极研究1994，6，2： | 2 |
| 11 | 中低收入国家的慢性病:背景、决定因素与卫生政策显示文摘近年来,中低收入国家慢性病不断上升的趋势及其产生的影响受到广泛关注,但有关这种上升趋势的解释和说明大多基于高收入国家的慢性病发展史,但其所经历的发展历程与中低收入国家并不完全相同。本文对这些差异进行评价,以更好地理解中低收入国家慢性病的流行趋势,并对慢性病决定因素的相关理论加以讨论,为慢性病的防控提供循证支持。此外,本文将慢性病防控政策看作是降低人口患病风险和个体易感性的重要干预手段,并讨论了中低收入国家需要开展的相关政策研究。在此基础上进一步强调了加强初级卫生保健改革的必要性,并将其作为降低慢性病流行趋势的一项重要政策。 | Miranda J J Kinra S Casas J P Davey Smith G Ebrahim S | 2013 | 中国卫生政策研究2013，6，10： | 2 |
| 12 | Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and metaanalysis 显示文摘 | Casas JP Chua W Loukogeorgakis S | 2005 | Lancet2005，366，9502： | 1 |
| 13 | Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer显示文摘 | SACCA P MEISS R CASAS G | 2007 | Cancer2007，97，： | 1 |
| 14 | A new single nucleotide polymorphism in CAPN1 extends the current tenderness marker test to include cattle of Boa indicus,Boa taurus,and crossbred descent显示文摘 | Casas E Wheeler T L | 2005 | J Anita Sci2005，83，： | 1 |
| 15 | Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis 显示文摘 | Bellamy L Casas JP Hingoran AD | 2009 | Lancet2009，373，9677： | 1 |
| 16 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 17 | Principles of ex ovo competitive exclusion and in ovo administration of Lactobacillus reuteri显示文摘 | EDENS F W PARKHURST C R CASAS I A | 1997 | Poultry Science1997，，76： | 1 |
| 18 | National athletic trainers' association position state- ment:preventing sudden death in sports显示文摘 | CASA D J GUSKIEWICZ K M ANDERSON | 2012 | J Athl Train2012，47，： | 1 |
| 19 | Assessment of single nuclcofide polymorphisms in genes residing on chromosomes 14 and 29 for associa- tion with carcass composition traits in Bos indicus cattle显示文摘 | Casas E White S N Riley D G | 2005 | Journal of Animal Science2005，83，： | 1 |
| 20 | Integrated care prevents hospitalisations for exacerbations in COPD patients显示文摘 | Casas A Troosters T Garcia-Aymerich J | 2006 | Eur Respir J2006，28，1： | 1 |
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