|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 精子DNA完整性与形态超高倍检测在辅助生殖技术妊娠结局中的临床价值显示文摘近年来,涌现出许多重要的男性不育诊疗新技术。本研究旨在探讨精@DNA完整性与精子空泡率检测对以男性不育因素行IvF或IcsI治疗的不育症的治疗结局。本研究针对152对不育症夫妻行ART技术前进行的精子DNA碎片率与形态学超高倍分析进行队列研究。我们发现对妊娠结局最有预测价值的DNA碎片率切点值为25.5%,阴性预测值为72.7%(P=0.02)。在对空泡率的研究中发现,3、4级的空泡精子的最有预测价值切点值为73.5%,阴性预测值为39.4%(P=0.09),差异无统计学意义。总之,当精子DNA碎片率大于25%时,IVF失败的概率增大,而精子形态学超高倍检测结果对预测患者的妊娠结局无明显获益。 | Gemma López Rafael Lafuente Miguel A Checa Ramón Carreras Mario Brassesco | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease显示文摘Cytomegalovirus(CMV) infection is common in humans.The virus then enters a 'latency phase' and can reactivate to different stimuli such as immunosuppression.The clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of CD.However,CMV reactivation is frequent in severe or steroid-resistant UC.It is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe disease.Different methods are used to diagnose CMV colitis.Diagnosis is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being investigated.Polymerase chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic mucosa.Specific endoscopic features have not been described in active UC and CMV infection.CMV colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive therapy.Other antiviral drugs may be used.Multicenter controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment. | Elena Garrido Elisa Carrera Rebeca Manzano Antonio Lopez-Sanroman | 2013 | World Journal of Gastroenterology2013，19，1： | 7 |
| 3 | 血管免疫母细胞性T细胞淋巴瘤:RHOA G17V突变显示文摘血管免疫母细胞性T细胞淋巴瘤(AITL)是一种较为少见的外周T细胞淋巴瘤亚型(占15—20%),起源于滤泡辅助T细胞。AITL是一种表现预后不良的侵袭性淋巴瘤,多数患者年龄超过50岁且表现为进展期病变,其中位生存期不到3年。AITL以多形性细胞浸润伴透明T细胞聚集为形态特征表现,但目前对其特异性分子遗传学特征的研究尚不清楚。RHOAG17V是一种体细胞突变,该突变可干扰RHOA蛋白与Rho-结合区的结合,使RHOA蛋白失去GTP酶活性,从而影响细胞增殖及侵袭行为。 | Nagao R Kikuti Y Y Carreras J 杨海玉 刘勇 | 2016 | 临床与实验病理学杂志2016，32，11： | 5 |
| 4 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 5 | 对明串珠菌及其他细菌的抑制效果显示文摘在从压榨间直到蔗汁澄清的蔗糖生产过程中,蔗汁中微生物活动是破坏蔗糖品质的一个重要因素。蔗糖损失和葡聚糖的形成通常与蔗汁中微生物引起的变质有关。多年来,这一直成为糖厂试图改善蔗糖品质时所面临的问题。本文以直接影响得糖率的微生物减少和相对纯度为指标,研究了不同杀菌方法在蔗汁中的效果。浓度为0.007%的S抑制剂显示了对某糖厂初压汁和混合汁中的微生物菌群的抗菌效应。在对照组中,12h后观察到4.8单位的纯度降低。加入S抑制剂后,只降低2个单位。且蔗汁的稳定性在3个样品中几乎完全一致。以S抑制剂处理的蔗汁保持深褐色和清新的气味,且pH与初始相比无显著变化,而未处理的蔗汁变浅褐色,产生很强的酒味,pH和纯度显著降低。这种稳定效应尚未被其他常用的糖用杀菌剂所报导。同样,本文证明了有可能通过使用S抑制剂来稳定混合汁。经S抑制剂处理后,游离的还原物质和多聚糖比不经处理的样品低6倍。这些结果表明,形成的葡聚糖以及随之形成的游离果糖减少。 | Georgina Michelena Aidin Martinez Graciela Cerutti Monica Coronel Antonio Bell Emilia Carrera Agustin Lopez-Murguia Roberto Portuondo Lazaro Mergarejo Frost M Steele 李宜海 | 2006 | 广西轻工业2006，22，4： | 3 |
| 6 | Pathogenesis of glaucoma: how to prevent ganglion cell from axonal destruction?显示文摘Glaucoma is the main cause of irreversible blindness globally,but the pathogenesis of glaucoma is still pending consensus.In spite of great advances during the 20th and early 21st centuries in terms of detailed knowledge of pathological processes that take place in glaucoma,the exact pathogenesis is much less clear.Hypotheses abound,and the most researched areas are ischemia at the optic nerve head,blockade of ganglion cell axonal transport,peripapillary atrophy,and changes in the characteristics of the lamina cribrosa(Nucci et al.,2008). | Francisco Javier Carreras | 2014 | Neural Regeneration Research2014，9，23： | 3 |
| 7 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 8 | Glaucoma and amyotrophic lateral sclerosis,two kindred diseases?显示文摘Amyotrophic lateral sclerosis(ALS),a predominantly sporadic disease with unknown etiology and pathogeny,is a member of a group known as motor neuron diseases(MND).The heterogeneity of the clinical presentation of the disease is a fundamental aspect of ALS and is determined by the variable engagement of its upper motor neuron(UMN)and lower motor neuron(LMN)components(Ravits and La Spada,2009). | Francisco Javier Carreras | 2016 | Neural Regeneration Research2016，11，9： | 2 |
| 9 | Current scenario of the genetic testing for rare neurological disorders exploiting next generation sequencing显示文摘Next generation sequencing is currently a cornerstone of genetic testing in routine diagnostics,allowing for the detection of sequence variants with so far unprecedented large scale,mainly in genetically heterogenous diseases,such as neurological disorders.It is a fast-moving field,where new wet enrichment protocols and bioinformatics tools are constantly being developed to overcome initial limitations.Despite the as yet undiscussed advantages,however,there are still some challenges in data analysis and the interpretation of variants.In this review,we address the current state of next generation sequencing diagnostic testing for inherited human disorders,particularly giving an overview of the available high-throughput sequencing approaches;including targeted,whole-exome and whole-genome sequencing;and discussing the main critical aspects of the bioinformatic process,from raw data analysis to molecular diagnosis. | Chiara Di Resta Giovanni Battista Pipitone Paola Carrera Maurizio Ferrari | 2021 | Neural Regeneration Research2021，16，3： | 2 |
| 10 | Basic Demographics, Health Practices, and Health Status of U.S. Medical Students显示文摘 | Erica Frank Jennifer S. Carrera Lisa Elon Vicki S. Hertzberg | 2006 | American Journal of Preventive Medicine2006，，6： | 2 |
| 11 | Temperature-dependent phonon spectra of magnetic random solid solutions显示文摘A first-principles-based computational tool for simulating phonons of magnetic random solid solutions including thermal magnetic fluctuations is developed.The method takes fluctuations of force constants due to magnetic excitations as well as due to chemical disorder into account.The developed approach correctly predicts the experimentally observed unusual phonon hardening of a transverse acoustic mode in Fe–Pd an Fe–Pt Invar alloys with increasing temperature.This peculiar behavior,which cannot be explained within a conventional harmonic picture,turns out to be a consequence of thermal magnetic fluctuations.The proposed methodology can be straightforwardly applied to a wide range of materials to reveal new insights into physical behaviors and to design materials through computation,which were not accessible so far. | Yuji Ikeda Fritz Körmann Biswanath Dutta Abel Carreras Atsuto Seko Jörg Neugebauer Isao Tanaka | 2018 | npj Computational Materials2018，，1： | 2 |
| 12 | , Performance of CrN/MoS2 (Ti) coatings for high wear low friction applications显示文摘 | Carrera S Salas O Moore J J | 2003 | Surface and Coatings Technology2003，167，： | 2 |
| 13 | The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression显示文摘巨噬细胞(目的) 的 Apoptosis 禁止者,人的 Spα 的一个相当或相同事物;,是一只老鼠 scavenger 受体的可溶的成员充满半胱氨酸的总科(SRCR-SF ) 。这个家庭集成没有统一功能还为被描述了的天生、适应的有免疫力的房间表示的一组蛋白质。多种的功能被归功于瞄准,从在在到在自体免疫的病理的类脂化合物新陈代谢和反煽动性的效果的 thymic 选择期间的淋巴细胞的生存能力支持。在现在的报告,目的病原体绑定性质被探索了。由使用在哺乳动物的细胞表示的目的(rAIM ) 的一种 recombinant 形式,这蛋白质能绑并且聚集克积极、克否定的细菌,以及病原、腐生的真菌的种类,这被显示出。重要地,浆液也绑在目的微生物和分泌物的从老鼠的内长的目的很快在跟随暴露到保存微生物引起的房间墙部件的老鼠怒气巨噬细胞被导致。老鼠 splenocytes 上的 ligands 也是的著名细菌、真菌的像使用费的受体(TLR ) 导致的 Cytokine 版本面对 rAIM 禁止了。而且,联系病原体的分子的模式(PAMP ) 的老鼠模型导致了腐败细菌、真菌的起源的吃惊证明浆液目的层次以一种时间依赖者方式变化了。总的来说,这些数据建议那个目的由在病原体侵略期间支持天生的体液的防卫起一个一般 homeostatic 作用。 | Vanesa G. Martinez Cristina Escoda-Ferran Ines Tadeu Simees Satoko Arai Marc Orta Mascaro Esther Carreras Mario Martinez-Florensa Jose Yelamos Toru Miyazaki Francisco Lozano | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 14 | Efficacy of the vaccination in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) is associated with conditions that may predispose to infections, such as the lack of an appropriate innate immune response to infectious agents, malnutrition, surgery, and immunosuppressive and biological drugs. Some of these infections may be preventable by vaccination. Therefore, for this particular patient population, the benefits of implementing a well-established immunization protocol in daily clinical practice are potentially even greater than for the general population. In recent years international consensus guidelines have been published, but in spite of theses recommendations, studies have shown that a significant number of patients with IBD remain inadequately immunized. Another important issue regarding immunization in this population is that vaccine efficacy among patients receiving immunosuppressive therapies has been variable. In a healthy population, a humoral immune response to hepatitis B vaccination (HBV) is expected in > 90%, whereas a much lower rate is achieved in the IBD patients. Immunosuppressive, anti-tumor necrosis factor therapy and disease activity have been implicated in the impaired efficacy of the vaccination. The serological response to HBV should be confirmed and patients with an inadequate response should receive a second full series of vaccine. Modified dosing regimens, including doubling the standard antigen dose, might increase the effectiveness. Response to influenza, pneumococcal and tetanus immunization is still not clear, as there are studies that show a normal response to the vaccination while others demonstrate a lack of efficacy. We pose a series of questions on the efficacy of the different vaccinations recommended for IBD patients and attempt to answer them using scientific evidence. | Elisa Carrera Rebeca Manzano Elena Garrido | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 15 | A proposed Global Boundary Stratotype Section and Point for the base of the Middle Ordovician Series: The Niquivil section, Precordillera of San Juan, Argentina显示文摘 | Guillermo L. Albanesi Marcelo G. Carrera Fernando L. Canas Matthew Saltzman | 2006 | Episodes2006，29，1： | 2 |
| 16 | Layered polymer-kaolinite nanocomposites显示文摘 | J. E. Gardolinski L. C. M. Carrera M. P. Cant?o F. Wypych | 2000 | Journal of Materials Science2000，，12： | 2 |
| 17 | Biological nitrogen removal of high-strength ammonium industrial wastewater with two-sludge system 显示文摘 | Carrera J Baeza J A Vicent T | 2003 | Water Research2003，37，： | 1 |
| 18 | Inactivation of phosphoglycerate mutase and creatine kinase isoenzymes in human serum显示文摘 | Carreras J Valentí M | 2002 | Mol Pathol2002，55，4： | 1 |
| 19 | Cerebrovascular Carbon Dioxide Reactivity and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage显示文摘 | Carrera E Kurtz P Radjatia N | 2010 | Arch Neurol2010，67，4： | 1 |
| 20 | Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis显示文摘 | Carreras FI Gradilone SA Mazzone A | 2003 | Hepatology2003，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员