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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 4 | Distributions of indoor and outdoor air pollutants in Rio de Janeiro,Brazil:implications to indoor air quality in bayside offices显示文摘 | Brickus L S R Cardoso J N Neto F R D A | 1998 | Environ Sci Technol1998，32，： | 1 |
| 5 | Locally recurrent or me- tastatic breast cancer:ESMO Clinical Practice Guidelines for diag- nosis,treatment and follow-up显示文摘 | Cardoso F Harbeck N Fallowfield L | 2012 | Ann Oncol2012，23，7： | 1 |
| 6 | ESO-ESMO 2nd internation- al consensus guidelines for advanced breast cancer (ABC2) 显示文摘 | Cardoso F Costa A Norton L | 2014 | Breast2014，23，5： | 1 |
| 7 | ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2) 显示文摘 | Cardoso F Costa A Norton L | 2014 | Breast2014，23，5： | 1 |
| 8 | Growth and yield of potatoes in relation to method of application of Zn fertilizers and to fungicides containing Zn显示文摘 | Moreira M A Fontes P C R Fontes R L F Cardoso A A | 2000 | Horticultura Brasileira2000，18，1： | 1 |
| 9 | Locally recurrent or meta- static breast cancer:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up显示文摘 | Cardoso F Harbeck N Fallowfield L | 2012 | Ann Oncol2012，23，7： | 1 |
| 10 | Clinical application of the70-gene profile:the MINDACT trial显示文摘 | Cardoso F Van't Veer L Rutgers E | 2008 | J Clin Oncol2008，26，： | 1 |
| 11 | Low temper- ature conversion of rice husks, eucalyptus sawdust and peach stones for the production of carbon-like adsorbent显示文摘 | Martins A F Cardoso A de L Stahl J A etal | 2007 | Bio-re source Technology2007，98，5： | 1 |
| 12 | Development of a multiplex PCR assay for polymorphism analysis of Brucella suis biova_rs causing bru- cellosis in swine 显示文摘 | Beck L F Cardoso R | 2006 | Vet Microbiol2006，115，： | 1 |
| 13 | C-reactive proteinprognostic accuracy in acute pancreatitis : timing of measurement and cutoffpoints显示文摘 | Cardoso F Ricardo L B Oliveira AM | 2013 | Eur J Gastroenterol Hepatol2013，25，7： | 1 |
| 14 | A simulated annealing approach to the solution of MINLP problems 显示文摘 | CARDOSO M F SALCEDO R L | 1997 | Comput Chem Eng1997，21，12： | 1 |
| 15 | Micro- structural analysis and tensile properties of squeeze cast Al-7Mg alloy显示文摘 | CARDOSO D B C DIAS M F MORAIS C A L | 2010 | Materials Science Forum2010，643，： | 1 |
| 16 | Lo-cally recurrent or metastatic breast cancer:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow up显示文摘 | Cardoso F Senkus-Konefka E fellowfield L | | 0，，5： | 1 |
| 17 | Serum levels of brain derived neurotrophic factor correlate with motor impairment in Parkinson' s disease显示文摘 | Scalzo P Kiimmer A Bretas T L Cardoso F Teixeira A L | 2010 | J Neurol2010，257，： | 1 |
| 18 | Aging response of the Ti-35Nb-7Zr-5Ta and Ti-35Nb-7Ta alloys显示文摘 | FERRANDINI P L CARDOSO F F SOUZA S A AFONSO C R CARAM R | 2007 | Journal of Alloys and Compounds2007，433，： | 1 |
| 19 | 1st International consensus guidelines for advanced breast cancer (ABC 1) 显示文摘 | Cardoso F Costa A Norton L | 2012 | Breast2012，21，3： | 1 |
| 20 | Mortality of mice as influenced by the hour of the day of drug (ara-C) administration显示文摘 | Cardoso S Scheving L Halberg F | 1970 | Pharmacologist1970，12，： | 1 |
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