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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 3 | Neurosyphilis in the modern em显示文摘 | Timmermans M Can J | 2004 | J Neurol Neumsurg Psychiatry2004，75，12： | 1 |
| 4 | Intrathoracic malignant peripheral nerve sheath tumor with angiosarcoma in a child with NF1显示文摘 | Elli M Can B Ceyhan M | 2007 | Tumori2007，93，6： | 1 |
| 5 | Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury显示文摘 | Can M Gul S Bektas S | 2009 | Acta Anaesthesiol Scand2009，53，8： | 1 |
| 6 | Complications associated with the ball,bar and Locator attachments for implant-supported overdentures显示文摘 | Cakarer S Can T Yaltirik M | | 0，，7： | 1 |
| 7 | Conservative treat- ment of scapular neck fracture : the effect of stability and glenopolar angle on clinical outcome 显示文摘 | Bozkurt M Can F Kirdemir V | 2005 | Injury2005，36，10： | 1 |
| 8 | The association between coronary atherosclerotic burden and asymmetric dimethylarginine,carotis intima media thickness and endothelial function显示文摘 | Can F Ziyrek M Erdem S | 2014 | Turk Kardiyol Dern Ars2014，12，： | 1 |
| 9 | Power-electronic systems for the grid integration of renewable energy sources: a survey显示文摘 | Can'asco J M Franquelo L G Bialasiewicz | 2006 | IEEE Transactions on-Industrial Electronics2006，53，4： | 1 |
| 10 | Effect of ball milling on simultaneous spark plasma synthesis and densification of TiC-TiB2 composites显示文摘 | Locci A M Orr'u R Can G | 2006 | Materials Science and Engineering A2006，，434： | 1 |
| 11 | A post-myocardial infarction interventricular septal defect显示文摘 | Canádyová J Mokrácek A Forst M | 2008 | Rozhl Chir2008，87，2： | 1 |
| 12 | Organization, program, and structure: An analysis of the Chinese in- novation policy framework 显示文摘 | Can H Amorim C Spinoglio M | 2004 | R&D Management2004，34，4： | 1 |
| 13 | Adsorption of boron from aqueous solutions by activated carbon impregnated with salicylic acid: Equilibrium, kinetic and thermodynamic studies显示文摘 | CAN BZ CEYLAN Z KOCAKERIM M M | 2012 | Desalination and Water Treatment2012，40，123： | 1 |
| 14 | Hydrody- namics and mixing in a multiple air-lift loop reactor 显示文摘 | Bakker W A M Van Can H J L Tramper J | 1993 | BiotechnolBioeng1993，42，8： | 1 |
| 15 | Mistakes in a stat laboratory: types and fre- quency 显示文摘 | Plebani M Can'am P | 1997 | Clin Chem1997，43，81： | 1 |
| 16 | Modulation of Na^+/H^+ exchange isoform mRNA expression in isolated rat hearts显示文摘 | Can XT Chakrabarti S Karmazyn M | 1999 | Am-J-Physiol1999，277，32： | 1 |
| 17 | Impact of Land Use and Land Cover Changes On Ecosystem Services in Menglun, Xishuangbanna, Southwest Chi- na显示文摘 | Hu H Liu W Can M | 2008 | Environ Monit Assess2008，，146： | 1 |
| 18 | Targeted deletion of the mouse POU domain gone Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling显示文摘 | XIANG M CAN L ZHOU L | 1996 | Pro: Nail Acad Sci USA1996，93，11： | 1 |
| 19 | A Proposal for Construction Project Risk Assessment Using Fuzzy Logic显示文摘 | Tah J H M Can' V | 2000 | Construction Management and Economics2000，18，4： | 1 |
| 20 | Dynamic traffic modeling for noise impact assessment of traffic strategies 显示文摘 | Can A chevalier E Nadji M | 2010 | Acta Acustica United With Acustica2010，96，3： | 1 |
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