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| 1 | Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection显示文摘AIM To address to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. METHODS The ability of the liver to regenerate is remarkable on both clinical and biological grounds. Basic mechanisms underlying this process have been intensively investigated. However, it is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system. We were able to follow the fate of single transplanted hepatocytes during the regenerative response elicited by 2/3 partial surgical hepatectomy(PH) in rats. Clusters of transplanted cells were 3D reconstructed and their size distribution was evaluated over time after PH. RESULTS Liver size and liver DNA content were largely recovered 10 d post-PH, as expected(e.g., total DNA/liver/100 gb.w. was 6.37 ± 0.21 before PH and returned to 6.10 ± 0.36 10 d after PH). Data indicated that about 2/3 of the original residual hepatocytes entered S-phase in response to PH. Analysis of cluster size distribution at 24, 48, 96 h and 10 d after PH revealed that about half of the remnant hepatocytes completed at least 2 cell cycles. Average size of hepatocytes increased at 24 h(248.50 μm2 ± 7.82 μm2, P = 0.0015), but returned to control values throughout the regenerative process(up to 10 d post-PH, 197.9 μm2 ± 6.44 μm2, P = 0.11). A sizeable fraction of the remnant hepatocyte population does not participate actively in tissue mass restoration. CONCLUSION Hyperplasia stands as the major mechanism contributing to liver mass restoration after PH, with hypertrophy playing a transient role in the process. | Fabio Marongiu Michela Marongiu Antonella Contini Monica Serra Erika Cadoni Riccardo Murgia Ezio Laconi | 2017 | World Journal of Gastroenterology2017，23，10： | 3 |
| 2 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 3 | Long-term outcome of laparoscopic ventral rectopexy for total rectal prolapse显示文摘 | D'Hoore A Cadoni R Penninckx F | 2004 | Br J Surg2004，91，5： | 1 |
| 4 | Serum fatty acids and cantiovascular risk factors in sudden sensorinearal heating loss: a case- control study显示文摘 | Cadoni G Scorpecci A Cianfrone F | 2010 | Am Otol Rhinol Iaryngol2010，119，2： | 1 |
| 5 | Strain-rate effect on the tensile behavior of concrete at different relative humidity levels显示文摘 | Cadoni E Labibes K Albertini C | 2001 | Materials and Structures/ Materiaux et Constructions2001，34，235： | 1 |
| 6 | Influence of aggregate size on strain-rate tensile behavior of concrete显示文摘 | CADONI E LABIBES K BERRA M | 2001 | ACI Mate- rials Journal2001，98，3： | 1 |
| 7 | Lack of association between inherited thrombophilic risk fact-ors and idiopathic sudden sensorineural hearing loss in Italian patients显示文摘 | Cadoni G Scipione S Rocca B | 2006 | Ann Otol Rhinol Laryngol2006，115，3： | 1 |
| 8 | Study of the Mechanical Properties of Plain Concrete Under Dynamic Loading显示文摘 | Albertini C Cadoni E | 1999 | Experimental Mechanics1999，39，2： | 1 |
| 9 | Early diagnosis and stage-adapted treatment of Wegener's granulomatosis 显示文摘 | Cadoni G Agostino S Campobasso E | 2003 | J Laryngol Otol2003，117，3： | 1 |
| 10 | Dyeing polyester fibers with disperse dyes in supercritical CO2显示文摘 | De Giorgi M R Cadoni E Maricca D | 2000 | Dyes and Pigments2000，45，1： | 1 |
| 11 | A case-control study on proinflammatory genetic polymorphisms on sudden sensorineural hearing loss显示文摘 | Cadoni G Gaetani E Picciotti P M | 2015 | Laryngoscope2015，125，1： | 1 |
| 12 | Supercritical CO2 extraction of lycopene and β-carotene from ripe to-matoes显示文摘 | Cadoni E De Giorgi M R Medda E | 2000 | Dyes and Pigments2000，44，1： | 1 |
| 13 | Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural heating loss in Italian patients显示文摘 | Cadoni G Scipione S Rocca B | 2006 | Ann Otol Rhinol Laryngol2006，115，3： | 1 |
| 14 | Strain-rate effect on the tensile behavior of concrete at different relative humidity levels显示文摘 | Cadoni E Labibes K Albertini C | 2001 | Materials and Structures2001，34，： | 1 |
| 15 | Human papillomavirus infection and cyclin D1 gene amplification in laryngeal squamous cell carcinoma: biologic function and clinical significance显示文摘 | Almadori G Galli J Cadoni G | 2002 | Head Neck2002，24，6： | 1 |
| 16 | Multi step laryngeal carcinogenesis helps our understanding of the field cancerisation phenomenon显示文摘 | ALMADORI G BUSSU F CADONI G | 2004 | Eur J Cancer2004，40，： | 1 |
| 17 | Catalytic DeNOx ac- tivity of cobalt and copper ions in microporous MeA1PO-34 and MeAPSO-34显示文摘 | Frache A Palella B Cadoni M | 2002 | Catal Today2002，75，14： | 1 |
| 18 | Autoimmunity in Sudden Sensorineural Hearing Loss: Possible Role of Anti-endothelial Cell Autoantibodies显示文摘 | Gabriella Cadoni Anna Rita Fetoni Stefania Agostino Antonella De Santis Raffaele Manna Fabrizio Ottaviani Gaetano Paludetti | 2002 | Acta Oto-Laryngologica2002，，5： | 1 |
| 19 | Dyeing polyester fibres with disperse dyes in supercritical CO2显示文摘 | GIORGI M R D CADONI E MARICCA D | 2000 | Dyes and Pigments2000，45，1： | 1 |
| 20 | Sudden sensofineural hearing loss: our experience in diagnosis, treatment, and outcome 显示文摘 | Cadoni G Agostino S Scipione S | 2005 | J Otolaryngol2005，34，6： | 1 |
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