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| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | Low-cost disordered carbons for Li/S batteries: A high- performance carbon with dual porosity derived from cherry pits显示文摘一微 -- 并且从樱桃坑废物获得并且与 H 3 PO 4 酸为 Li/S 电池作为硫主人被学习了。碳有 1,662 m 2 灀楡的一个高特定的表面区域吗? | Celia Hernandez-Rentero Rafael Cordoba Noelia Moreno Alvaro Caballero Julian Morales Mara Olivares-Marin Vicente Gomez-Serrano | 2018 | Nano Research2018，11，1： | 7 |
| 3 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 4 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 5 | Slip-model Performance for Underexpanded Micro-scale Rocket Nozzle Flows显示文摘在太空微机电的系统(MEMS ) ,流动的典型长度规模接近分子的吝啬的免费路径,因此使连续统描述无效并且强制粒子方法的使用象直接模拟蒙特卡罗(DSMC ) 一样,处理非平衡区域。在滑倒政体以内(0.01 < Kn < 锝 ?.1 ) 两条途径,连续统并且基于粒子,似乎以精确性表现很好。现在的学习总结与第二顺序获得的实现和结果在一个海军司烧解答者滑动边界状况在嘴墙附近探讨变成稀薄。它到 300 渭 m 的一张冷气体的微规模的圆锥形的嘴的评价和申请咽直径,排出进低压的 freestream,组成工作的主要目的。滑倒模型合并速度滑倒与热爬并且温度跳,因此允许也处理非等温的流动。结果证明气体在嘴唇附近经历强烈变成稀薄,指向模型有效性的限制。而且,强壮的马赫减速被观察,归因于相当厚的亚声的边界层,超声的体积加热引起了由粘滞驱散,在有扩大到的对比在 underexpanded 期间发生在大火箭嘴操作。 | JoséA.Morí■igo JoséHermidaQuesada Francisco Caballero Requena | 2007 | Journal of Thermal Science2007，16，3： | 4 |
| 6 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 7 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 8 | Physical activation of graphene: An effective, simple and clean procedure for obtaining microporous graphene for high-performance Li/S batteries显示文摘Graphe ne nano sheets are a promising scaffold to accommodate S for achievi ng high performa nee Li/S battery. Nano sheet activation is used as a viable strategy to induce a micropore system and further improve the battery performance. Accordingly, chemical activation methods dominate despite the need of multiple stages, which slow down the process in addition to making them tiresome. Here, a three-dimensional (3D) N-doped graphene specimen was physically activated with CO2, a clean and single step process, and used for the preparation of a sulfur composite (A-3DNG/S). The A-3DNG/S composite exhibited outstanding electrochemical properties such as an excellent rate capability (1,000 mAh·g^-1 at 2C), high reversible capacity and cycling stability (average capacity ~ 800 mAh·g^-1 at 1C after 200 cycles), values which exceed those measured in chemically activated graphene. Therefore, these results support the use of physical activation as a simple and efficient alternative to improve the performance of carbons as an S host for high-performance Li-S batteries. | Almudena Benitez Alvaro Caballero Julian Morales Jusef Hassoun Enrique Rodriguez-Castellon Jesus Canales-Vazquez | 2019 | Nano Research2019，12，4： | 3 |
| 9 | Very strong bainite显示文摘 | F.G. Caballero H.K.D.H. Bhadeshia | 2004 | Current Opinion in Solid State & Materials Science2004，，3： | 3 |
| 10 | Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization显示文摘 | Grant MB May WS Caballero S | | 0，，： | 2 |
| 11 | Carbon supersaturation of ferrite in a nanocrystalline bainitic steel显示文摘 | F.G. Caballero M.K. Miller C. Garcia-Mateo | 2009 | Acta Materialia2009，，7： | 2 |
| 12 | gFACs:Gene Filtering,Analysis,and Conversion to Unify Genome Annotations Across Alignment and Gene Prediction Frameworks显示文摘Published genomes frequently contain erroneous gene models that represent issues associated with identification of open reading frames,start sites,splice sites,and related structural features.The source of these inconsistencies is often traced back to integration across text file formats designed to describe long read alignments and predicted gene structures.In addition,the majority of gene prediction frameworks do not provide robust downstream filtering to remove problematic gene annotations,nor do they represent these annotations in a format consistent with current file standards.These frameworks also lack consideration for functional attributes,such as the presence or absence of protein domains that can be used for gene model validation.To provide oversight to the increasing number of published genome annotations,we present a software package,the Gene Filtering,Analysis,and Conversion(gFACs),to filter,analyze,and convert predicted gene models and alignments.The software operates across a wide range of alignment,analysis,and gene prediction files with a flexible framework for defining gene models with reliable structural and functional attributes.gFACs supports common downstream applications,including genome browsers,and generates extensive details on the filtering process,including distributions that can be visualized to further assess the proposed gene space.gFACs is freely available and implemented in Perl with support from BioPerl libraries at http://gffzzfe7b028a01ac400fs66f9qxnxfpcw6vxx.ffgz.tsg.suse.edu.cn/PlantGenomicsLab/gFACs. | Madison Caballero Jill Wegrzyn | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 2 |
| 13 | The system Clinker–MgO–CaZrO 3 and its application to the corrosion behavior of CaZrO 3 /MgO refractory matrix by clinker显示文摘 | S. Serena M.A. Sainz A. Caballero | 2009 | Journal of the European Ceramic Society2009，，11： | 2 |
| 14 | Wear of nano-structured carbide-free bainitic steels under dry rolling–sliding conditions显示文摘 | A. Leiro E. Vuorinen K.G. Sundin B. Prakash T. Sourmail V. Smanio F.G. Caballero C. Garcia-Mateo Roberto Elvira | 2012 | Wear2012，，： | 2 |
| 15 | Small cell carcinoma of the urinary bladder treated with chemotherapy radiotherapy: results in five cases显示文摘 | Bastus R Caballero J M Gronzalez G | 1999 | Eur Urol1999，35，： | 2 |
| 16 | Bubbles and capital flow volatility: Causes and risk management 显示文摘 | Caballero R J Krishnamurthy A | 2006 | Journal of Monetary Economics2006，53，1： | 1 |
| 17 | Deve- lopment of Hard Bainite 显示文摘 | GAarcia-Mateo C Caballero F G Bhadeshia H K D H | 2003 | ISIJ Int2003，43，8： | 1 |
| 18 | Array comparative genomic hybridization identifies genetic regions associated with outcome in aggressive dif- fuse large B-cell lymphomas显示文摘 | Robledo C Garcia JL Caballero D | 2009 | Cancer2009，115，16： | 1 |
| 19 | Chemical state and distribution of Mn ions in the absence and the presence of fluxes显示文摘 | Navarrete E L Caballero A Gonzalez - Elipe A R | 2004 | Journal of the Europe Ceramic Society2004，，24： | 1 |
| 20 | Oxygen lattice instability as a capacity fading mechanism for 5 V cathode materials显示文摘 | Caballero A Hernan L Melero M | 2005 | J Electrochem Soc2005，152，1： | 1 |
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