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| 1 | A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells显示文摘CCL5 是响应压力信号在有免疫力、非有免疫力的房间的一个宽数组表示的 CC chemokine 家庭的一个成员。有先进人的乳癌的 CCL5 表示相互关联。然而,它行动的功能的意义和模式没被建立。这里,我们证明 CCL5 缺乏的老鼠对高度好攻击的、三元组否定的乳房的肿瘤生长抵抗。造血的 CCL5 在这显型是主导的。造血的 CCL5 的缺席由积累 Ly6C +/Gr-1+, 的异常产生导出 myeloid 的 suppressor 房间(MDSC )> 嗨有损害能力到的 和 Ly6G + MDSC 压制 CD8 + T 房间的 cytotoxicity。CCL5 的这些性质在 orthotopic 和自发的乳房的肿瘤被观察。CCL5 的调停抗体的全身的封锁禁止肿瘤前进并且对非产生免疫性的肿瘤提高治疗学的种痘的功效。CCL5 也帮助维持人的 MDSC 的抑制免疫力的能力。我们的学习揭开经由与导出肿瘤的刺激殖民地的因素在合作在骨头髓产生 MDSC 支持乳房的肿瘤前进的造血地导出的 CCL5 的一项新奇、 chemokine 独立的活动。学习在在造血的分隔空间和肿瘤壁龛之间的相互影响上打开可观的灯。因为在正常生理学的这个分子的明显的非必需的性质, CCL5 可以象有 MDSC 渗入的重要数量的大量稳固的肿瘤一样为乳癌在免疫疗法代表一个优秀治疗学的目标。 | Yan Zhang Dandan Lv Ha-Jeong Kim Robert A Kurt Wen Bu Yi Li Xiaojing Ma | 2013 | Cell Research2013，23，3： | 9 |
| 2 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 3 | Physiological responses of artificial moss biocrusts to dehydration-rehydration process and heat stress on the Loess Plateau, China显示文摘Ex-situ cultivation of biological soil crusts(biocrusts) is a promising technology to produce materials that can induce the recovery of biocrusts in the field for the purposes of preventing soil erosion and improving hydrological function in degraded ecosystems. However, the ability of artificially cultivated biocrusts to survive under adverse field conditions, including drought and heat stresses, is still relatively unknown. Mosses can bolster biocrust resistance to the stresses(e.g., drought and heat) and the resistance may be introduced prior to field cultivation. In this study, we subjected the well-developed artificial moss biocrusts(dominant species of Didymodon vinealis(Brid.) Zand.) that we cultivated in the phytotron to a dehydration-rehydration experiment and also a heat stress experiment and measured the activities of protective enzymes(including peroxidase(POD), superoxide dismutase(SOD), and catalase(CAT)) and the contents of osmoregulatory substances(including soluble proteins and soluble sugars) and malondialdehyde(MDA, an indicator of oxidative stress) in the stem and leaf fragments of mosses. The results showed that, during the dehydration process, the activities of protective enzymes and the contents of osmoregulatory substances and MDA gradually increased with increasing duration of drought stress(over 13 days). During the rehydration process, values of these parameters decreased rapidly after 1 d of rehydration. The values then showed a gradual decrease for 5 days, approaching to the control levels. Under heat stress(45°C), the activities of protective enzymes and the content of soluble proteins increased rapidly within 2 h of heat exposure and then decreased gradually with increasing duration of heat exposure. In contrast, the contents of soluble sugars and MDA always increased gradually with increasing duration of heat exposure. This study indicates that artificial moss biocrusts possess a strong drought resistance and this resistance can be enhanced after a gradual dehydration treatment. This study also indicates that artificial moss biocrusts can only resist short-term heat stress(not long-term heat stress). These findings suggest that short-term heat stress or prolonged drought stress could be used to elevate the resistance of artificial moss biocrusts to adverse conditions prior to field reintroduction. | BU Chongfeng WANG Chun YANG Yongsheng ZHANG Li Matthew A BOWKER | 2017 | Journal of Arid Land2017，9，3： | 4 |
| 4 | Pyrolytic conversion of methyland vinylsilane polymers to Si-C ceramics 显示文摘 | HURWITZ F I KACIK T A BU X Y | 1995 | J Mater Sci1995，30，： | 2 |
| 5 | The reactions between Ca-based solids and gases representative of those found in a fluidized-bed incinerator显示文摘 | LAWRENCE A D BU J | 2000 | Chemical Engineering Science2000，55，24： | 2 |
| 6 | Polyoxometalates matrixed into surfactants: synthesis, characterizations, and conformations of surfactants 显示文摘 | BU W F WU L X TANG A Q | 2004 | J Colloid Interf Sci2004，269，： | 1 |
| 7 | 3DFLOW Development and Validation for Three Cases-Downward Mixing, Partition and Displacement Ventilation显示文摘 | A Li Jones P Z Bu | 2003 | International Journal of Ventilation2003，2，2： | 1 |
| 8 | Thedirect release of nitric oxide by Gypenoside derived from theHerb Gynostemma pentaphyllum显示文摘 | Miles A Tanner Xin Bu J Alan Steimle P R Myers | 1999 | Biology and Chemis-try1999，3，5： | 1 |
| 9 | Antidiabetic effect of ginsengoside Rb3 in alloxan-induced diabetic mice 显示文摘 | BU Q T ZHANG W Y CHEN Q C et a l | 2012 | Med Chem2012，8，5： | 1 |
| 10 | A review of catalytic hydrodeoxygenation of lignin-derived phenols from biomass pyrolysis显示文摘 | BU Q LEI H ZACHER A H | 2012 | Bioresource Technology2012，124，3： | 1 |
| 11 | Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos显示文摘 | Bu P Evrard Y A Lozano G | 2007 | Mol Cell Biol2007，27，9： | 1 |
| 12 | Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB显示文摘 | Bu DX Hemdahl AL Gabrielsen A | 2006 | Am J Pathol2006，169，6： | 1 |
| 13 | Managed Pressure Drill- ing (MPD) Field Trials Demonstrate Technology Value 显示文摘 | Saponja J Adeleye A Hucik Bu | 2006 | IADC/SPE 987872006，，： | 1 |
| 14 | ZnⅡ coordination poylmers based on,2,3,6,7-anthracenetetracarboxylic acid:synthesis,structures,and luminescence properties显示文摘 | Chang Z Zhang A S Hu T L Bu X H | | 0，，： | 1 |
| 15 | Cloning and characterization of a novel gene (TM7SF1) encoding a putativeseven-pass transmembrane protein that is upregulated during kidney development 显示文摘 | SPANGENBERG C WINTERPACHT A ZABEL BU | 1998 | Genomies1998，48，2： | 1 |
| 16 | De t e r i o r a t i n g h e a 1 t h s t a t us in Stockholm 1998 -2002: r e s u 1 t s from repeated popu a t ionsur v e y s u s i n g t h e EQ - 5D 显示文摘 | Bu r s t r m K J o h a n n e s s o n M Re h n b e r g C | 2007 | Qua 1 L i f e Re s2007，16，9： | 1 |
| 17 | lmp|ementing screening for distress,the 6 vital sign:a Canadian strategy for changing practice显示文摘 | Bu|tz BD Groff SL Fitch M et a/ | 2011 | Psychooncology2011，20，5： | 1 |
| 18 | T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidyl- serine and mediate phagocytosis of apoptotic cells显示文摘 | Dekruyff RH Bu X Ballesteros A | 2010 | J Immunol2010，184，4： | 1 |
| 19 | Study of alendronate in avascular necrosis of bone显示文摘 | Agarwala S Sule A Pai BU | 2001 | J Assoc Physicians India2001，49，： | 1 |
| 20 | Apoptosis:one of the mechanisms that maintains unresponsiveness of the intestinal mucosal immune system显示文摘 | Bu P Keshavarzian A Stone DD | 2001 | Immunol2001，166，10： | 1 |
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