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| 1 | Camouflage Patterning in Maize Leaves Results from a Defect in Porphobilinogen Deaminase显示文摘玉米叶子从导致沿着叶的长轴穿的同种细胞的房间系的极化的房间部门被生产。我们利用了这个 stereotypical 部门模式识别形成违背同种细胞的房间系的叶绿体色素沉着部门的许多异种。这里,我们描述 camouflage1 (cf1 ) 异种,开发 nonclonal,在它的叶子的 yellowgreen 部门。我们由标注的 transposon 克隆 cf1 基因并且决定它编码 porphobilinogen 脱氨基酶(PBGD ) ,在叶绿素和 heme 早工作的酶生合成。当 PBGD 生物化学地被描绘了时,在这基因的可行变化都没在植物被报导。调查在里面 PBGD 的 vivo 功能,我们描绘了 cf1 异种。组织学的分析表明 cf1 黄扇区显示捆鞘的新奇显型房间特定的死亡。轻移动的实验决定经常的光压制了 cf1 部门形成,黑暗 / 轻的转变被要求仅仅在叶开发的一有限时间期间导致黄部门,和那种部门形式。生物化学的实验决定 cf1 异种叶子减少了 PBGD 活动和在绿、黄的区域的酶底层的增加的层次。而且, cf1 黄区域在过氧化氢酶活动显示了减小。一个阀值模型被假设向 cf1 解释上色并且合并光合的细胞区别,清除的反应的氧种,和 PBGD 功能。 | Mingshu Huanga Thomas L. Slewinski R. Frank Baker , Diane Janick-Buckner Brent Buckner Gurmukh S. Johal David M. Braun | 2009 | Molecular Plant2009，2，4： | 6 |
| 2 | Presentation,management,and outcome of newly diagnosed glioblastoma in elderly patients显示文摘OBJECT: Optimum management for elderly patients with newly diagnosed glioblastoma(GBM) in the temozolomide(TMZ) era is not well defined.The object of this study was to clarify outcomes in this population.METHODS: The authors retrospectively reviewed 105 consecutive cases involving elderly patients(age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.RESULTS: The patients' median age was 74 years(range 66-87 years),and the median Karnofsky Performance Status(KPS) score was 80(range 40-90).Half of the patients underwent biopsy and half underwent resection.Patients with deep-seated lesions(19 patients [18%]) or multifocal lesions(34 patients [32%]) were more likely to have biopsy than resection(p = 0.0001 and 0.0009,respectively).New persistent neurological deficits developed in 7 patients(6.7%).Postoperative hemorrhage occurred in 6 patients(5.7%),all of whom underwent biopsy.Complete follow-up data regarding adjuvant treatment was available in 84 patients.Forty-one(49%) were treated with chemotherapy(mostly TMZ) and radiation therapy(RT),and 23(27%) with RT alone.Nineteen(23%) received only palliative care after surgery(more common with biopsy,p = 0.03).Chemotherapy complications occurred in 28.6%(Grade 3 or 4 hematological complications in 11.9%).The median values for progression-free survival(PFS) and overall survival(OS) were 3.5 and 5.5 months.In a multivariate analysis,younger age(p = 0.03,risk ratio [RR] 0.34,95% CI 0.13-0.89),single lesion(p = 0.02,RR 0.51,95% CI 0.30-0.89),resection(p = 0.04,RR 0.54,95% CI 0.31-0.94),and adjuvant treatment(p = 0.0001,RR 0.24,95% CI 0.11-0.49) were associated with better OS.Only adjuvant treatment was significantly associated with prolonged PFS(p = 0.0007,RR 0.27,95% CI 0.13-0.57).With combined therapy with resection,RT,and chemotherapy,the median PFS and OS were 8 and 12.5 months,respectively.CONCLUSIONS: The prognosis for GBM worsens with increasing age in elderly patients.With important risks,resection and adjuvant treatment are associated with prolonged survival.Although selection bias cannot be excluded in this retrospective study,advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy. | Tanaka S Meyer FB Buckner JC Uhm JH Yan ES Parney IF | 2013 | 中国神经肿瘤杂志2013，11，1： | 4 |
| 3 | Selective averaging of rapidly presented individual trials using fMRI显示文摘 | Dale AM Buckner RL | 1997 | Hum Brain Map1997，5，： | 2 |
| 4 | Keratoconus in a patient with Alport syndrome: A case report显示文摘BACKGROUND Known ocular manifestations of Alport syndrome include features such as anterior lenticonus and fleck retinopathy. Reports of keratoconus in such patients are limited. We report tomographic findings consistent with keratoconus in a patient with Alport syndrome.CASE SUMMARY A 52-year-old female was referred to our ophthalmology clinic with decreased vision and increased tearing. She was diagnosed with stage Ⅲ Alport syndrome two years prior. Upon examination she was found to have average keratometries of 48D bilaterally with tomographic evidence of keratoconus.CONCLUSION Although a rare presentation, concurrent Alport syndrome and keratoconus should be considered when reviewing the ocular health of Alport syndrome patients and appropriate management steps should be taken upon the diagnosis. | Majid Moshirfar David F Skanchy Aaron T Gomez Yasmyne C Ronquillo Benjamin Buckner Phillip C Hoopes | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 5 | Selective averaging of rapidly presented individual trials using fMRI显示文摘 | Dale AM Buckner RL | 1997 | Human Brain Mapping1997，5，： | 2 |
| 6 | A phase Ⅰ and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer显示文摘 | HIDALGO M BUCKNER JC ERLICHMAN C | 2006 | Clln Cancer Res2006，12，19： | 1 |
| 7 | Management of recurrent meningeal hemangiopericytoma 显示文摘 | Galanis E Buckner JC Scheithauer BW | 1998 | Cancer1998，82，11： | 1 |
| 8 | Treatment of brain metastases from melanoma显示文摘 | MCWILLIAMS R R BROWN P D BUCKNER J C et el | 2003 | Mayo Clin Proc2003，78，12： | 1 |
| 9 | Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability,and relation to Alzheimer' s disease 显示文摘 | Buckner RL Sepulcre J Talukdar T | 2009 | J Neurosci2009，29，6： | 1 |
| 10 | Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+)regulatory T cells in human autoimmune diseases显示文摘 | Buckner JH | 2010 | Nature Rev Immunol2010，10，12： | 1 |
| 11 | Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+)regulatory T cells in human autoimmune disea- ses显示文摘 | Buckner JH | 2010 | Nat Rev Immunol2010，10，12： | 1 |
| 12 | Treatment of nomal donors with recombinant growth factors for transplantation of allogeneic blood stem cells显示文摘 | Bensinger W Buckner CD Rowley S | 1996 | Bone Marrow Transplant1996，17，2： | 1 |
| 13 | Bemisia tabaci (Hemiptera: Aleyrodidae) nymphal feeding in cotton (Gossypium hirsutum) leaves显示文摘我们使用了明亮的地电子显微镜学( BEM ),微分干扰对比显微镜学( DICM ),扫描电子显微镜学( SEM ),传播电子显微镜学( TEM ),并且扫描显微镜学( CLSM )在棉花在 nymph 的喂的行为期间调查 Bemisia tabaci 的锥刺小径的共焦的激光离开以离开轴心的叶面的穿入开始并且在韧皮部纸巾在筛管与锥刺结束。在渗透叶纸巾的唾液的鞘以内的最 nymph 的锥刺做了复杂拐弯并且在在筛管结束前开发了超过一个唾液的鞘分支。唾液的鞘和他们的线路在之间并且通过叶房间的外部形态学在现在的学习期间被描述。结果在筛管以内显示出锥刺的存在。B。tabaci 美女可以在不同筛管移开锥刺和 feed。从近轴的表面显示出锥刺穿入的前进到筛管的十部短电影被纳入图 8—15。报告和电影能从因特网被看。到一个本地人的电影首先在你的计算机驾驶为的下载快上载。电影能在生物学班上被用作一件教具。 | CHANG-CHI CHU DENNIS A. MARGOSAN JAMES S. BUCKNER THOMAS P. FREEMAN THOMAS J. HENNEBERRY | 2007 | Insect Science2007，14，5： | 1 |
| 14 | FOXP3 and the regulation of Treg/Thl7 differentiation显示文摘 | Ziegler SF Buckner JH | 2009 | Microbes and Infection2009，11，5： | 1 |
| 15 | The brain's default network: anatomy, function, and relevance to disease显示文摘 | Buckner RL Andrews Hanna JR Schacter DL | 2008 | Ann N Y Acad Sci2008，1124，10： | 1 |
| 16 | Mechanisms of impaired regulation by CD4+ CD25+FOXP3+ regulatory T cells in human autoimmune diseases显示文摘 | Buckner JH | 2010 | Nat Rev Immunol2010，10，12： | 1 |
| 17 | Knowledge, resilience, and effectiveness of education in a young teen asthma camp 显示文摘 | Buckner EB Hawkins AM Stover L | 2005 | Pediatric Nuts2005，31，20： | 1 |
| 18 | Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience显示文摘 | McElroy E A Jr Buckner J C Lewis J E | 1998 | Neurosurgery1998，52，5： | 1 |
| 19 | Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix显示文摘 | Buckner L R Schust D J Ding J | 2011 | J Reprod Immunol2011，92，2： | 1 |
| 20 | Nutrient composition of spoiled and non-spoiled wet byproducts mixed and stored with straw显示文摘 | Yelden J R Buckner C D Rolfe K M | 2011 | Nebraska Beef Cattle Reports2011，644，： | 1 |
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