|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human papillomavirus and gastrointestinal cancer: A review显示文摘Human papillomavirus(HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common,and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic,but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri,penis,vulva,vagina,anus and oropharynx,including the base of the tongue and the tonsils. However,studies of the aetiological role of HPV in colorectal and esophageal malignancies have conflicting results. The aim of this review was to organize recent evidence and issues about the association between HPV infection and gastrointestinal tumours with a focus on esophageal,colorectal and anal cancers. The ultimate goal was to highlight possible implications for prognosis and prevention. | Dania Bucchi Fabrizio Stracci Nicola Buonora Giuseppe Masanotti | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 2 | Physiology and pharmacology of the cardiac pacemaker ('funny') current 显示文摘 | Baruscotti M Bucchi A DiFrancesco D | 2005 | Pharmacol Ther2005，107，1： | 1 |
| 3 | Current-dependent block of rabbit sino-atrial node If channels by ivabradine显示文摘 | Bucchi A Baruscotti M DiFrancesco D | 2002 | J Gen Physiol2002，120，： | 1 |
| 4 | When Scientists Tum To The Public : Alternative Routes In Science Communication显示文摘 | Bucchi M | 1996 | Public Understanding of Science1996，5，4： | 1 |
| 5 | Modulation of cyclic nucleo-tide- regulated HCN channels by PIP (2) and receptors coupled to phospholipase C 显示文摘 | Plan P Bucchi A Decostanzo A | 2007 | P flugers Arch2007，455，1： | 1 |
| 6 | Exercise training reduces resting heart rate via downregulation of the funny channel HCN4 显示文摘 | D'Souza A Bucchi A Johnsen A B | 2014 | Nat Commun2014，5，5： | 1 |
| 7 | Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration显示文摘AIM:To investigate the molecular events involved in liver regeneration following subtotal hepatectomy (SH) as previous studies have largely focused on partial hepatectomy (PH). METHODS: Male Wistar rats were subjected to 70% PH or 90% SH, respectively, and sacrificed at different times after surgery. Untreated and sham-operated animals served as controls. Serum and liver samples were obtained to investigate liver function, apoptosis (TUNEL assay) and transcription factors (NF-κB,Stat3; ELISA) or cytokines (HGF, TNF-a,IL-6,TGF-a,TGF-b; quantitative RT-PCR) involved in liver regeneration. RESULTS:Serum levels of ALT and AST in animals with 70% PH differed significantly from sham-operated and control animals. We found that the peak concentration 12 h after surgery returned to control levels 7 d after surgery. LDH was increased only at 12 h after 70% PH compared to sham. Bilirubin showed no differences between the sham and 70% resection. After PH, early NF-κB activation was detected 12 h after surgery (313.21±17.22 ng/mL), while there was no activation after SH (125.22 ± 44.36 ng/mL) compared to controls (111.43±32.68 ng/mL) at this time point. In SH, however, NF-κB activation was delayed until 24 h (475.56±144.29 ng/mL). Stat3 activation was similar in both groups. These findings correlated with suppressed and delayed induction of regenerative genes after SH (i.e. TNF-a 24 h postoperatively: 2375±1220 in 70% and 88±31 in 90%; IL-6 12h postoperatively:2547±441 in 70% and 173±82 in 90%). TUNEL staining revealed elevated apoptosis rates in SH (0.44% at 24 h;0.63% at 7d) compared to PH (0.27% at 24h; 0.15% at 7d). CONCLUSION: The molecular events involved in liver regeneration are significantly influenced by the extent of resection as SH leads to suppression and delay of liver regeneration compared to PH, which is associated with delayed activation of NF-κB and suppression of proregenerative cytokines. | Jan-Peter Sowa Jan Best Tamas Benko Maximillian Bockhorn Yanli Gu Eva-Maria Niehues Agnieska Bucchi Eva-Maria Benedetto-Castro Guido Gerken Ursula Rauen Jorg Friedrich Schlaak | 2008 | World Journal of Gastroenterology2008，14，46： | 1 |
| 8 | Physiology and pharmacology of the cardiac pacemaker (' funny' ) current显示文摘 | Baruscotti M Bucchi A DiFrancesco D | 2005 | Pharmacol Ther2005，107，1： | 1 |
| 9 | Physiology and pharmacology the cardiac pacemaker ( ' funny' ) current 显示文摘 | Baruscotti M Bucchi A Difrancesco D | 2005 | Pharmacol Ther2005，107，1： | 1 |
| 10 | Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker 显示文摘 | Bucchi A Plotnikov AN Shlapakova IN | 2006 | Circulation2006，114，： | 1 |
| 11 | Current-dependent block of rabbit sino-atrial node If channel by ivabradine 显示文摘 | Bucchi A Baruscotti M DiFrancesco D | 2002 | J Gen Physiol2002，120，1： | 1 |
| 12 | Physiology and pharmacology of the cardiac pacemaker ( 'funny' ) current 显示文摘 | Baruscotti M Bucchi A Difrancesco D | 2005 | Pharmacol Ther2005，107，1： | 1 |
| 13 | Transpiration cooling performance in LOX/Methane liquid-fuel rocket engines 显示文摘 | BUCCHI A BRUNO C | 2005 | Journal of Spacecraft and Rockets2005，42，3： | 1 |
| 14 | Investigation of transpiration cooling performance in LOX/Methane liquid rocket engines显示文摘 | BUCCHI A CONGIUNTI A BRUNO Claudio | 2003 | IAC2003，，10： | 1 |
| 15 | The cardiac pacemaker current显示文摘 | Baruscotti M Barbuti A Bucchi A | 2010 | J Mol Cell Cardiol2010，48，1： | 1 |
| 16 | Physiology and pharmacology of the cardiac pacemaker ('funny') current显示文摘 | Baruscotti M Bucchi A Difrancesco D | 2005 | Pharmacology & Therapeutics2005，107，1： | 1 |
| 17 | Physiology and pharmacology of the cardiac pacemaker ('funny') current显示文摘 | BARUSCOTTI M BUCCHI A DIFRANCESCO D | 2005 | Pharmacol Ther2005，107，1： | 1 |
| 18 | HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with Ⅰ (f) blockade 显示文摘 | Plotnikov AN Bucchi A Shlapakova I | 2008 | Heart Rhythm2008，5，2： | 1 |
| 19 | Physiology and pharmacology of the cardiac pacemaker( 'funny' ) current 显示文摘 | Baruscotti M Bucchi A DiFrancesco D | 2005 | Pharmacol Ther2005，107，1： | 1 |
| 20 | Physiology and pharmacology of the cardiac pacemaker( 'funny' ) current 显示文摘 | Baruscotti M Bucchi A Difrancesco D | 2005 | Pharmacol Ther2005，107，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员