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| 1 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 2 | Acute onset of hemorrhagic leukoencephalomyelitis(Hurst)in the spinal cord显示文摘 | Brunn A Nacimiento W Sellhaus B | 2002 | Clin Neuropathol2002，21，5： | 1 |
| 3 | Multi - slice spiral CT of the coronary arteries: clear vascular imaging using standard software显示文摘 | Frohner S Brunn J | 2001 | Rontgenpraxis2001，54，4： | 1 |
| 4 | The expression of dentin sialophosphoprotein gene in bone显示文摘 | Qin C Brunn JC Cadena E | 2002 | J Dent Res2002，81，6： | 1 |
| 5 | The expression of dentin sialophosphoprotein gene in bone显示文摘 | Qin C Brunn JC Cadena E | 2002 | J Dent Res2002，81，6： | 1 |
| 6 | Rapamycin induced inhibition of P34^cdc2 kinase activation is associated with G1/ S phase growth arrest in T lymphocytes显示文摘 | Morise WG Brunn GJ Wiederrecht G | 1993 | J Biol Chem1993，268，： | 1 |
| 7 | Phosphorylation of the translational repressor PHAS-1 by the mammalian target of rapamycin显示文摘 | Brunn GJ Hudson CC Sekulic A | 1997 | Science1997，277，5322： | 1 |
| 8 | Difficult prehospital endotracheal intubation - predisposing factors in a physician based EMS显示文摘 | Breckwoldt J Klemstein S Brunne B | 2011 | Resuscitation2011，82，12： | 1 |
| 9 | Two interesting begign hmg tll/nolx3 of contiadictory histopatholog Y显示文摘 | Brunn H | 1939 | J Thorac Surg1939，，9： | 1 |
| 10 | Statistical investigations into the structural complementarity of natural products and synthetic compounds 显示文摘 | Brunne R M Mtller H | 1999 | Angew Chem Int Ed Engl1999，38，5： | 1 |
| 11 | Selective suppression of Toll -like receptor 4activation by chemokine receptor 4 显示文摘 | Kishore SP Bungum MK Platta JL Brunn GJ | 2005 | FEBS Let- ters2005，579，： | 1 |
| 12 | Effects of pulsed high- frequency electromagnetic fields on the neuroendocrine system 显示文摘 | MANN K WAGNER P BRUNN G | 1998 | Neuroendocrinology1998，67，2： | 1 |
| 13 | Extracellular matrix proteins and the dynamics of dentin formation 显示文摘 | Butler WT Brunn JC Qin C | 2002 | Connect Tissue Res2002，43，23： | 1 |
| 14 | Using recombinant activated factor VII,B-Lynch compression,and reversible embolization of the u-terine arteries for treatment of sever econservatively intractable postpar-tum hemorrhage:new method for management of massive hemorrhage in cases of placenta 显示文摘 | Mechsner S Baessler K Brunne B | | 0，，： | 1 |
| 15 | E-Marketplaces:crafting a winning strategy显示文摘 | BRUNN P JENSEN M SKOVGAARD J | 2002 | European Management Journal2002，，6： | 1 |
| 16 | Volumetric analysis of thyroid lobes by real-time ultrasound显示文摘 | Brunn J Block U Ruf G | 1981 | Dtsch Med Wochenschr1981，106，41： | 1 |
| 17 | Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies显示文摘 | MOTHE S I BRUNN G J MCMAHON L P | 2000 | J Biol Chem2000，275，33： | 1 |
| 18 | Expression pattern and cellular sources of chemokines in primary central nervous system lymphoma显示文摘 | BRUNN A MONTESIONOS RONGEN M STRACK A | 2007 | Acta Neuropathol2007，114，3： | 1 |
| 19 | Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4显示文摘 | Johnson G B Brunn G J Kodaira Y | 2002 | J Immunol2002，168，10： | 1 |
| 20 | A wall layer correction for ultrasound measurement in tube flow: comparison between theory and experiment 显示文摘 | Brunn P O | 2000 | Flow-Measurement and Instrumentation2000，11，： | 1 |
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