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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Use of magnetic resonance cholangiography in the diagnosis of choledocholithiasis显示文摘 | Gallix B P Regent D Bruel J M | 2001 | Abdom Imaging2001，26，： | 1 |
| 3 | Impact of induced thermal stress duringcirculation tests in an engineered fractured geothermalreservoir显示文摘 | Bruel D | 2002 | Oil & Gas Science and Technology2002，57，5： | 1 |
| 4 | Viable skin efficiently absorbs and metabolizes bisphenol A 显示文摘 | Zalko D Jacques C Duplan H Bruel S Perdu E | 2011 | Chemosphere2011，82，3： | 1 |
| 5 | Impact of induced thermal stress during circulation tests in an engineered fractured geothermal reservoir显示文摘 | Bruel D | 2002 | Oil & Gas Science and Technology2002，，45： | 1 |
| 6 | 法国商品猪场对中欧杂交猪生产性能的试验结果初报显示文摘 | 郁明发 Laurence BRUEL | 1986 | 国外畜牧学(猪与禽)1986，，03： | 1 |
| 7 | Di-agnostic value of laboratory tests in identifying serious infec-tions in febrile children:systematic review显示文摘 | Van den Bruel A Thompson MJ Haj-Hassan T | 2011 | BMJ2011，342，： | 1 |
| 8 | Thermally activated persulfate oxidation of Ttrichloroethylene(TCE) andl 1, 1, l-trichloroethane(TCA) in aqueous systems and soil slurries显示文摘 | Liang C J Bruel C J Marley M C | 2003 | Soil Sediment Contain2003，12，2： | 1 |
| 9 | Silicon on insulator material technology 显示文摘 | Bruel M | 1995 | Electron Lett1995，31，14： | 1 |
| 10 | Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries : a systematic review显示文摘 | Van den Bruel A Haj-Hassan T Thompson M | 2010 | Lancet2010，375，9717： | 1 |
| 11 | Numerical study of the impact of fluid density on the pressure distribution and stimulated volume in the Soultz HDR reservoir显示文摘 | Baujard C Bruel D | 2006 | Geothermics2006，35，： | 1 |
| 12 | Riedel's thyroiditis and retroperitoneal fibrosis in multifocal fibrosclerosis : positron emission tomographic findings 显示文摘 | Drieskens O Blockmans D van den Bruel A | 2002 | Clin Nucl Med2002，27，6： | 1 |
| 13 | Basic mechanisms involved in the smart-cut process显示文摘 | ASPAR B BRUEL M MORICEAU H | 1997 | Microelectron Eng1997，36，14： | 1 |
| 14 | Silicon on insulator material technology显示文摘 | Bruel M | 1995 | Electronics Letters1995，31，14： | 1 |
| 15 | Silicon on insulator material technology 显示文摘 | Bruel M | 1995 | Electronics Letters1995，31，14： | 1 |
| 16 | Epithelial induction of porcine suppressor of cytokine signaling 2(SOCS2)gene expression in response to Entamoeba histolytica显示文摘 | Bruel T Guibon R Melo S | 2010 | Developmental&Comparative Immunology2010，34，5： | 1 |
| 17 | Bhedopsin kinase Expression in baculovirus-infected insect cells,and characterization of post-translational modifications显示文摘 | Cha K Bruel C Inglese J | 1997 | Proc Natl Acad Sci USA1997，94，10： | 1 |
| 18 | Diagnostic value of laboratory tests in identifying serious infections in febrile children : systematic review显示文摘 | van den Bruel A Thompson MJ Haj-Hassan T | 2011 | BMJ2011，342，2： | 1 |
| 19 | Application of hydrogen ion beams to silicon on insulator material technology 显示文摘 | Bruel M | 1996 | Nucl Instrum Methods Phys Res B1996，108，： | 1 |
| 20 | Diagnostic value of laboratory tests in identifying serious in febrite children systenmatic review显示文摘 | Van den Bruel A Thompson MJ Haj-Hassan T | 2011 | BMJ2011，8，342： | 1 |
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