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| 1 | Tumor reactive stroma in cholangiocarcinoma:The fuel behind cancer aggressiveness显示文摘Cholangiocarcinoma(CCA) is a highly aggressive epithelial malignancy still carrying a dismal prognosis, owing to early lymph node metastatic dissemination and striking resistance to conventional chemotherapy. Although mechanisms underpinning CCA progression are still a conundrum, it is now increasingly recognized that the desmoplastic microenvironment developing in conjunction with biliary carcinogenesis, recently renamed tumor reactive stroma(TRS), behaves as a paramount tumor-promoting driver. Indeed, once being recruited, activated and dangerously co-opted by neoplastic cells, the cellular components of the TRS(myofibroblasts, macrophages, endothelial cells and mesenchymal stem cells) continuously rekindle malignancy by secreting a huge variety of soluble factors(cyto/chemokines, growth factors, morphogens and proteinases). Furthermore, these factors are long-term stored within an abnormally remodeled extracellular matrix(ECM), which in turn can deleteriously mold cancer cell behavior. In this review, we will highlight evidence for the active role played by reactive stromal cells(as well as by the TRS-associated ECM) in CCA progression, including an overview of the most relevant TRS-derived signals possibly fueling CCA cell aggressiveness. Hopefully, a deeper knowledge of the paracrine communications reciprocally exchanged between cancer and stromal cells will steer the development of innovative, combinatorial therapies, which can finally hinder the progression of CCA, as well as of other cancer types with abundant TRS, such as pancreatic and breast carcinomas. | Simone Brivio Massimiliano Cadamuro Mario Strazzabosco Luca Fabris | 2017 | World Journal of Hepatology2017，9，9： | 3 |
| 2 | F-actin in acrosome-reacted boar spermatozoa显示文摘 | Castellani-Ceresa L Brivio M F Radaelli G | 1992 | Mol Reprod Dev1992，33，1： | 1 |
| 3 | The treatment of fracture with a dynamic fixator 显示文摘 | De Bastiani G Aldeghe riR Renzi Brivio L | 1984 | J Bone Joint Surg(Br)1984，66，： | 1 |
| 4 | Tumor necrosis factor in solid tumors: increased blood levels in the metastatic disease显示文摘 | Ardizzoia A Lissoni P Brivio F | 1992 | J Biol Regul Homeost Agents1992，6，3： | 1 |
| 5 | Circulating immature and mature dendritic cells in relation to lymphocyte subsets in patients with gastrointestinal tract cancer显示文摘 | Lissoni P Brivio E Ferrante R | 2000 | Int J Bio Markers2000，15，： | 1 |
| 6 | A correlation between optical properties from satellite data and some indicators of en trophication in Lake Garda (Italy) 显示文摘 | ZILIOLI E BRIVIO P A GOMARASCA M A | 1994 | The Science of the Total Environment1994，158，： | 1 |
| 7 | Pre-operative IL-2 immunoprophylaxis of cancer recurrence:long-term clinical results of a phase Ⅱ study in radically operable colorectal cancer显示文摘 | Brivio F Lissoni P Fumagalli L | 1999 | Oncol Rep1999，6，6： | 1 |
| 8 | Single-layer MoS2 transistors 显示文摘 | Radisavljevic B Radenovic A Brivio J | 2011 | Nat Nanotechnol2011，6，3： | 1 |
| 9 | Treatment of non-union of the humerus using the Orthofix external fixator 显示文摘 | Lavini F Renzi Brivio L Pizzoli A | 2001 | Injury2001，324，： | 1 |
| 10 | The treatment of fractures with a dynamic axial fixation显示文摘 | BASTIANIG ALDEGHERiR RENZI BRIVIO L | 1984 | J Bone Joint Suny(Br)1984，66，： | 1 |
| 11 | Circulating immature and mature dendritic cells in relation to lymphocyte subsets in patients with gastrointestinal tract cancer显示文摘 | Lissni P Brivio F Ferranle R | 2002 | Int J Biol Markets2002，12，1： | 1 |
| 12 | Enhancement of the efficacy of chemotherpy with oxaliplatin plus 5-fluorouracil by pre-treatment with IL-2 subcutaneous immunotherapy in metastatic colorectal cancer patients with lymphocytopenia prior to therapy显示文摘 | Lissoni P Brivio F Fumagalli L | 2005 | In Vivo2005，19，6： | 1 |
| 13 | the treatment of fractures with a dynamic axial fixator 显示文摘 | DEBASTRANI G ALGEGHERI R BRIVIO LR | 1984 | J Bone Joint Surg1984，66，： | 1 |
| 14 | Which immunological parameters are clinically essential to monitor IL-2cancer immunotherapy显示文摘 | Lissoni P Brivio F Viviani S | 1999 | J Biol Regul Homeost Agents1999，13，2： | 1 |
| 15 | Epitaxial growth of Fe/BaTiO3 heterostructures显示文摘 | Brivio S Rinaldi C Petti D | 2011 | Thin Solid Films2011，519，： | 1 |
| 16 | A Correlation between Op-tical Properties from Satellite Data and Some Indicators of Eu-trophication in Lake Garda(Italy)显示文摘 | Zilioli E Brivio P A Gomarasca M A | 1994 | The Science of the TotalEnvironment1994，158，： | 1 |
| 17 | Modulation of immune responses of Rhynchophorus ferrugineus (Insecta: Coleoptera)induced by the entomopathogenic nematode Steinernema carpocapsae (Nematoda: Rhabditida)显示文摘这研究的目的是调查在红手掌象鼻虫(RPW ) 之间的关系 Rhynchophorus ferrugineus (Olivier ) 和 entomopathogenic 线虫 Steinernema carpocapsae (杀虫剂的一种) ;特别地,工作与 EPN 一起在天真的幼虫并且在感染以后集中于昆虫主人的有免疫力的反应。二个主要免疫学的过程被探讨了:主机 prophenoloxidase-phenoloxidase (proPO ) 的活动和调整系统,在不自我和为不自我封装负责的血球识别进程的 melanization 包含了。而且,寄生虫的有免疫力的压抑、有免疫力的逃避的策略被调查了。我们的结果建议 RPW 拥有一个有效免疫系统,然而在感染的早阶段, S。carpocapsae 导致主人 proPO 系统的强壮的抑制。另外,招待封装的调停房间的机制,被寄生虫完全避免,逃犯 S 的策略。carpocapsae 似乎与它的身体表面的结构有关,自从导致,寄生虫表皮的改变导致了它的模仿的性质的损失。S。在它的共生细菌的版本前的 carpocapsae,压抑并且逃避 RPW 有免疫力的防卫,与目的指向为它昆虫的败血症的死亡负责的细菌安排有利环境。 | Maristella Mastore Vincenzo Arizza Barbara Manachini Maurizio F. Brivio | 2015 | Insect Science2015，22，6： | 1 |
| 18 | Circulating immature and mature dendritic cells in relation to lymphocyte subsets in patients with gastrointestinal tract cancer 显示文摘 | Lissoni P Brivio F Ferrante R | 2000 | Int J Biol Markers2000，15，1： | 1 |
| 19 | Single-layer MoS2 transistors 显示文摘 | RADISAVLJEVIC B RADENOVIC A BRIVIO J | 2011 | Nature Nanoteeb- nology2011，6，3： | 1 |
| 20 | At- omislic origins of high-performance in hybrid hal ide perovskite solar cells显示文摘 | FROST J M BUTLER K T BRIVIO F | 2014 | Nano Letters2014，14，5： | 1 |
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