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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Full-scale tests of bridge components strengthened using carbon fiber-reinforced polymer composites显示文摘 | BRENA S F WOOD S L KREGER M E | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 3 | Structure and bonding of water on Pt(111)显示文摘 | Ogasawara H Brena B Nordlund D | 2002 | Physical Review Letters2002，89，27： | 1 |
| 4 | Effect of carbon-fiber-reinforced polymer laminate configuration on the behavior of strengthened reinforced concrete beams显示文摘 | Brena S F Marci B M | 2004 | Journal of Composites for Construction A S CE2004，8，3： | 1 |
| 5 | Simultaneous detection of influenza A, B , and C viruses ,respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested-PeR assay显示文摘 | Coiras MT Perez -Brena P Garcia ML | 2003 | J Med Virol2003，69，1： | 1 |
| 6 | Increasing flexural capacity of reinforced concrete beams using carbon fibre-reinforced polymer composites 显示文摘 | Brena S F Bramblett R M Wood S L | 2003 | ACI Structure Journal2003，100，1： | 1 |
| 7 | Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells显示文摘 | Chung TL Brena RM Kolle G | 2010 | Stem Cells2010，28，10： | 1 |
| 8 | Increasing flexural capacity of reinforced concrete beams using carbon fiber-reinforced polymer composites显示文摘 | S F Brena R M Bramblett S Wood | 2003 | ACI Structural Journal2003，100，1： | 1 |
| 9 | Quantitative assessment of DNA methylation: potential applications for disease diagnosis, classification, and prognosis in clinical settings 显示文摘 | Brena RM Huang TH Plass C | 2006 | J Mol Med2006，84，5： | 1 |
| 10 | Accurate quantification of DNA methylstion using combined bisullite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform显示文摘 | Brena R M Auer H Kornacker K | 2006 | Nucleic Acids Res2006，34，3： | 1 |
| 11 | Abd-B expression in Porcellio scaber Latreille, 1804 ( Isopoda : Crustacea) : conserved pattern ver- sus novel roles in development and evolution显示文摘 | Brena C Liu P Z Minelli A | 2005 | Evol Dev2005，7，1： | 1 |
| 12 | Genome-epigenome interactions in cancer 显示文摘 | Brena RM Costello JF | 2007 | Hum Mol Genet2007，16，1： | 1 |
| 13 | Expression of trunk Hox genes in the centipede Strigamia maritima: sense and anti-sense transcripts 显示文摘 | Brena C Chipman A D Minelli A | 2006 | Evol Dev2006，8，3： | 1 |
| 14 | Use of DNA microarray technology and gene expression profiles to investigate the pathogenesis,cell biology,antifungal susceptibility and diagnosis of Candida albicans 显示文摘 | GARAIZAR J BRENA S BIKANDI J | 2006 | FEMS Yeast Research2006，6，7： | 1 |
| 15 | Functiona~ analysis of 5-1ipoxygenase promoter repeat variants显示文摘 | Vikmanl S Brena M M Armstrong P | 2009 | Hum Mol Genet2009，18，23： | 1 |
| 16 | Increasing Flexural Capacity of Reinforced Concrete Beams Using Carbon FiberReinforced Polymer Composites显示文摘 | Brena S F Bramblet R M Wood S L | 2003 | ACI Structural Journal2003，100，1： | 1 |
| 17 | Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform显示文摘 | Brena R M Auer H Kornacker K | 2006 | Nucleic Acids Res2006，34，3： | 1 |
| 18 | Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia显示文摘 | Hackanson B Bennett KL Brena RM | 2008 | Cancer Res2008，68，： | 1 |
| 19 | Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes 显示文摘 | Benigni A Colsiol V Brena C | 1998 | Diabetes1998，47，： | 1 |
| 20 | Unselective inhibition of endothelin receptors reduces renal dysfunction in experimentel Diabetes显示文摘 | Bbenigni A Colossio V Brena C | 1998 | Diabetes1998，47，： | 1 |
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