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| 1 | Transcriptional Activation and Production of Tryptophan-Derived Secondary Metabolites in Arabidopsis Roots Contributes to the Defense against the Fungal Vascular Pathogen Verticillium Iongisporum显示文摘忍受土壤的真菌的病原体 Verticillium longisporum 在象 oilseed 强奸那样的 Brassicaceae 主人植物上引起脉管的疾病。真菌开拓殖民地于根木部并且向上搬到疾病症状变得可见的叶子。为早基因正式就职把 Arabidopsis 用作一个模型,我们分别地在孢子萌芽以后并且在根外皮的穿入期间立即响应菌丝的生长执行了根 transcriptome 分析。感染的根显示出象抄写因素的激活那样的基因表示的快速的 reprogramming,应力 -- ,并且防卫相关的基因。这里,我们集中了于导致导出色氨酸的第二等的代谢物的生产的高度协调的基因正式就职。在叶子的以前的研究证明 CYP81F2 和 PEN2 (PENETRATION2 ) 编码的酶执行抗真菌的吲哚 glucosinolate (IGS ) 的形成代谢物。在感染 Verticillium 的根,我们发现 transcriptional CYP81F2 和 PEN2 的激活相当或相同的事物 PEL1 (PEN2-LIKE1 ) ,而是抗真菌的 IGS 故障产品的没有增加。相反, indole-3-carboxylic 酸(I3CA ) 和 phytoalexin camalexin 在感染的根积累了,但是仅仅 camalexin 在 vitro 禁止了 Verticillium 生长。而导致 camalexin 或 CYP81F2 依赖的 IGS 代谢物的单个新陈代谢的小径的基因混乱没改变导致 Verticillium 的疾病症状, cyp79b2 cyp79b3 异种在两个分支损害了导致了显著地提高的危险性。因此,我们的数据提供卓见进根特定的早防卫并且对脉管的病原体作为活跃抗真菌的混合物建议导出色氨酸的代谢物。 | Tim Iven Stefanie Konig Seema Singh Susanna A. Braus-Stromeyer Matthias Bischoff Lutz F. Tietze Gerhard H. Braus Volker Lipka Ivo Feussner Wolfgang Droge-Laser | 2012 | Molecular Plant2012，5，6： | 4 |
| 2 | 聚乙二醇干扰素/利巴韦林治疗丙型肝炎期间发生的感染与绝对淋巴细胞计数下降相关显示文摘虽然聚乙二醇干扰素(PEG-INF)治疗丙型肝炎期间常引起骨髓抑制,但白细胞计数的下降与发生感染风险的关系仍未确定。一项随机、平行、多中心Ⅲ期IDEAL(Individualized Dosing Efficacy vs Flat Dosing to Assess Optimal Pegylated Interferon Therapy)研究,旨在确定PEGINF/利巴韦林治疗丙型肝炎期间感染发生的概率和危险因素。 | Melia MT Brau N Poordad F 何高丽 张菁 | 2015 | 中国感染与化疗杂志2015，15，4： | 2 |
| 3 | Antipsychotic drug effects on motor activation measured by functional magnetic res- ona nce imaging in schizophrenic patients 显示文摘 | Braus DF Ende G Weber-Fahr W | 1999 | Schizophr Res1999，39，1： | 1 |
| 4 | Mycelial Morphology and Metabolite Production显示文摘 | Brau S Vecht-Lifshitz S E | 1991 | Trends Biotechnol1991，9，2： | 1 |
| 5 | Transforming growth factor-beta specifically induce proteins involved the myofibroblast contractile apparatus显示文摘 | Malmstrom J Lindberg C Brau C | 2004 | Mol Cell Proteomics2004，5，： | 1 |
| 6 | Do Venture Capitalists Add Value to Small Manufacturing Firms? An Empirical Analysis of Venture and Non- ventur e Capital - backed Initial Public of ferings 显示文摘 | Brau J C Brown R A Oster young J S | 2004 | Journal of Small Business Management2004，42，1： | 1 |
| 7 | Global Cancer Statis- tics, 2012显示文摘 | TORRE L A BRAU F SIEGEL R L | 2015 | CA cancer J Clin2015，65，2： | 1 |
| 8 | Initial public offerings:An analysis of theory and practice显示文摘 | Brau J Fawcett S | | 0，，01： | 1 |
| 9 | How Fast are Small Tourism Countries Growing?: Evidence from the Data for 1980 -2003 显示文摘 | Brau R Lanza a Pigliaru F | 2007 | Tourism Economics2007，13，4： | 1 |
| 10 | Cloning and expression of the structural gene for pyruvate decarboxylase of Zymomonas mobilis in Escherichia coli 显示文摘 | Brau B Sham H Zhang M | 1986 | Arch Microbiol1986，144，： | 1 |
| 11 | Dystonia following head trauma: a report of nine patients and review of the literature 显示文摘 | Mohadjer M Braus DF | 1992 | Mov Disord1992，7，3： | 1 |
| 12 | Glycogen resynthesis in the absence of food ingestion during recovery from moderate or high intensity physical activity: novel insight from rat and human studies 显示文摘 | Fournier P A Brau L Ferreira L D | 2002 | Comparative Biochemistry and Physiology Part A: Physiology2002，133，： | 1 |
| 13 | Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis显示文摘 | Ding J Shen J Brau DP | 2001 | Hum Reprod2001，16，9： | 1 |
| 14 | Fire retardant synergisms between anometrie Fe203 and aluminum phosphinate in poly (but',lem~ terephthalate)显示文摘 | GALLO E SCHARTEL B BRAU N U | 2011 | Pulymers for Advanced Technologies2011，22，12： | 1 |
| 15 | The Choice of IPO versus Takeover: Empirical Evidence显示文摘 | BRAU J C FRANCIS B KOHERS N | 2003 | The Journal of Business2003，76，4： | 1 |
| 16 | Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na+ cur- rents in rat sensory neurons 显示文摘 | Brau ME Dreimann M Olschewski A | 2001 | Anesthesiology2001，94，1： | 1 |
| 17 | Energy transfer in near-resonant molecular collisions due to long- range forces with application to transfer of vibra- tional energy from v3 mode of CO2 to N2 显示文摘 | SHARMA R D BRAU C A | 1969 | The Journal of Chemical Physics1969，50，2： | 1 |
| 18 | Non-oxide Ⅳ A V A-Ⅵ A chalcogenide glasses显示文摘 | HILTON A R JONES C E BRAU M | 1966 | Phys Chem Glasses1966，7，4： | 1 |
| 19 | ATO-dependent potassium channel in rat cardiomyocytes is blocked by lidocaine: possible impact on the antiarhyth mic action of lidocaine显示文摘 | Olschewski A Brau M Olschewski H | 2000 | Circulation2000，93，4： | 1 |
| 20 | Investigation of radiation damage effects in neutron irradiated CCD显示文摘 | Brau James E Olga Igonkina Potter Chris T | 2005 | Nuclear instruments & methods in physics research2005，549，6： | 1 |
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