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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Local dynamics in DNA by temperature-dependent stokes shifts of an intercalated dye 显示文摘 | Brauns E B Murphy C J Berg M A | 1998 | J Am Chem Soc1998，120，： | 1 |
| 3 | The influence of brassinosteroids on growth and parameters of photosynthesis of wheat and mustard plants 显示文摘 | Braun P Wild A | 1984 | Plant Physiol1984，116，： | 1 |
| 4 | Spontaneous apoptosis of endometrial tissue isimpaired in women with endometriosis显示文摘 | Gebel HM Braun DP Tambur A | 1998 | Fertil Steri11998，69，6： | 1 |
| 5 | Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis显示文摘 | Gebel IIM Braun DP Tambur A | 1998 | Fertil Steril1998，69，： | 1 |
| 6 | Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants显示文摘 | Ballabh P Braun A Nedergaard M | 2004 | Pediatr Res2004，56，1： | 1 |
| 7 | A Universal Technique for Fast and Flexible Instruction-set Architecture Simulation显示文摘 | Braun G Nohl A | 2004 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems2004，23，12： | 1 |
| 8 | Platelet CD40 ligand(CD40L)-subcellular localization,regulation of expression,and inhibition by clopidogrel显示文摘 | Hermann A Rauch BH Braun M | 2001 | Platelets2001，12，2： | 1 |
| 9 | Method of treating femur head dislocation fractures显示文摘 | Weckbach A Braun W Ruter A | 1989 | Unfallchirurgie1989，15，1： | 1 |
| 10 | Spontaneous apoptosis of endometrial tissue is impaired in women with endornetfiosis 显示文摘 | Gebel I M Braun DP Tambur A | 1998 | Fertil Steril1998，69，： | 1 |
| 11 | Photo- chemical processes for water-treatment显示文摘 | LEGRINI O OLIVEROS E BRAUN A M | 1993 | Chemical Reviews1993，93，2： | 1 |
| 12 | Isolation of a human intestinal bacterium capable of daidzein and genistein conversion显示文摘 | MATTHIES A BLAUT M BRAUNE A | 2009 | Appl Environ Microbiol2009，，75： | 1 |
| 13 | Post experience advertising effects on consumer memory显示文摘 | Braun K A | 1999 | Journal of Consumer Research1999，25，4： | 1 |
| 14 | Relative Indicators and Relational Charts for Comparative Assessment of Publication Output and Citation Impact 显示文摘 | Schubert A Braun T | 1986 | Scientometries1986，9，56： | 1 |
| 15 | Anatomic analysisof blood vessels in germinal matrix, cerebral cortex, andwhite matter in developing infants显示文摘 | Ballabh P Braun A Nedergaard M | 2004 | Pediatr Res2004，56，1： | 1 |
| 16 | Analysis of Gravity Recovery and Climate Experiment time-variable MSSA redistribution signals over North America by means of principal component analysis显示文摘 | RANGELOVA E VAN DER WAL W BRAUN A | 2007 | Journal of Geophysical Research2007，112，3： | 1 |
| 17 | The posterior two- portal approach of reconstruction of scapula fractures: results of 39 patients显示文摘 | Pizanis A tosounidis G Braun C | 2013 | Injury2013，44，11： | 1 |
| 18 | Carbon speciation in airbome particulate matter with C (1 s)NEXAFS spectroscopy 显示文摘 | Braun A | 2005 | Journal of Envi- ronmentalMonitoringJem2005，7，11： | 1 |
| 19 | D*Dπ and B* Bπ couplings in QCD显示文摘 | Braun V M Khodjamirian A | 1995 | Phys Rev1995，51，： | 1 |
| 20 | Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white m atter in developing infants 显示文摘 | Ballabh P Braun A Nedergaard M | 2004 | Pediatr Res2004，56，1： | 1 |
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