|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 3 | Determination of Lead in Biological Samples by High-resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Direct Solid Sampling显示文摘 | BORGES D G DA SILVA A F WELZ B | 2006 | JAnal at Spectrom2006，21，： | 1 |
| 4 | Suagrcane yellow leaf virus : a novel member of the Luteoviridae that probably arose by inter-species recombination 显示文摘 | Smith G R Borg Z Lockhart B E | 2000 | J Gen Virol2000，81，： | 1 |
| 5 | ERBB2 amplification is associated with tamoxifen resistance in steroid-receptor positive breast cancer显示文摘 | Borg A Baldetorp B Ferno M | 1994 | Cancer Lett1994，81，2： | 1 |
| 6 | Cytokines in Mycoplasma hyorhinis-induced arthritis in pigs bred selectively for high and low immune responses 显示文摘 | Jayagopala Reddy N R Wilkie B N Borgs P | 2000 | Infect Immun2000，68，3： | 1 |
| 7 | A survey on incidence and factors that May influence first postoperative urination显示文摘 | Ringdal M Borg B Hellstrom AL | 2003 | Urol Nurs2003，23，5： | 1 |
| 8 | Information Technology Impact on Market Orientation in E-Bus- iness显示文摘 | BORGES M HOPPEN N LUCE F B | 2009 | Journal of Business Research2009，62，9： | 1 |
| 9 | Comparison of markers of coagulation activation and thrombin generation test in uncomplicated pregnancies 显示文摘 | Joly B Barbay V Borg JY | 2013 | Thromb Res2013，132，3： | 1 |
| 10 | Identifying improvements in water management of bus-washing stations in Brazil显示文摘 | Almeida C M V B Borges J D Bonilla S H | 2010 | Resources Conservation and Recycling2010，54，11： | 1 |
| 11 | Uric acid as a marker for renal dysfunction in hypertensive women on diuretic and nondiuretic therapy显示文摘 | Borges R L Himta A H Quinto B M | 2009 | J Clin Hypertens(Greenwich)2009，11，5： | 1 |
| 12 | Delays in recogni- tion and management of giant cell arteritis: results from a retrospective audit显示文摘 | Ezeonyeji AN Borg FA Dasgupta B | 2011 | Clin Rheumatol2011，30，2： | 1 |
| 13 | Primary non-Hodgkin'slymphoma of the spleen presenting as space occupying lesion : A casereport and review of literature显示文摘 | Ambulkar I Kulkami B Borges A | 2006 | Leuk Lymphoma2006，47，1： | 1 |
| 14 | Identification of new protein species among 33 different small GTP-binding proteins encoded by cDNAs from Lotus japonicus and expression of corresponding mRNAs in developing root nodules显示文摘 | Borg S Brandstrup B Jensen TJ | 1997 | Plant J1997，11，： | 1 |
| 15 | Influence of endodontic sealers on the bond strength of carbon fiber posts显示文摘 | Teixeira CS Pastemak-Junior B Borges AH | 2008 | J Biomed Mater Res Part B Appl Biomater2008，84，2： | 1 |
| 16 | The collagen matrix of the heart显示文摘 | Borg TK Caulfied B | 1981 | Fed Proc1981，40，： | 1 |
| 17 | Endotracheal balloon dilation and stent implantation in benign stenosis 显示文摘 | Schmidt B Olze H Borges AC | 2001 | Ann Thorac Surg2001，71，5： | 1 |
| 18 | Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats显示文摘 | BORGES L P BRANDAO R GODOI B | 2008 | Chem Biol Interact2008，171，1： | 1 |
| 19 | Tryptophan and threonine requirements of young pigs and their effects on ser- um calcium,phosphorous and zinc concentrations显示文摘 | Borg B S Lihal G W Wahlstom R C | 1987 | J Anim Sci1987，64，： | 1 |
| 20 | Androgens in teleost fishes 显示文摘 | Borg B | 1994 | Comparative Biochemistry and Physiology Part C: Pharmacology Toxicology and Endocrinology1994，109，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员