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| 1 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 2 | Static friction coefficient model for metallic rough surfaces 显示文摘 | Chang W R Etsion I Bogy D B | 1988 | ASME Journal of Tribology1988，110，1： | 1 |
| 3 | Adhesion model for metallic rough surfaces显示文摘 | Chang W R Etsion I Bogy D B | 1988 | Journal of Tribology1988，110，1： | 1 |
| 4 | Use of an upwind finite volume method to sovle the air bearing problem of hard disk drives显示文摘 | Wu L Bogy D B | 2000 | Com-putational Mechanics2000，26，6： | 1 |
| 5 | A Numerical Study of Air-Beating Slider Form-Factors显示文摘 | Thornton B H Bogy D B | 2004 | ASME Journal of Tribology2004，126，： | 1 |
| 6 | A Numerical Scheme for Static and Dynamic Simulation of Subambient Pressure Shaped Rail Sliders 显示文摘 | Cha Ellis Bogy D B | 1995 | ASME Journal of Tribology1995，117，1： | 1 |
| 7 | Controlling chaos显示文摘 | Ott E Gre'bogi C Yorke J A | 1990 | Phys Rev Lett1990，64，11： | 1 |
| 8 | Edge-bonded dissimilar orthogonal elasticwedges under normal and shear loading显示文摘 | BOGY D B | 1968 | Journal ofApplied Mechanics1968，35，3： | 1 |
| 9 | Numerical simulation of the slider air bearing problem of hard disk drives by two multidimensional upwind residual distribution schemes over unstructured triangular meshes显示文摘 | Wu L Bogy D B | 2001 | Journal of Computational Physics2001，172，2： | 1 |
| 10 | Stress singularities at interface corners in bonded dissimilar isotropic elastic materials 显示文摘 | Bogy D B Wang K C | 1971 | Solids aml Structures1971，7，8： | 1 |
| 11 | Anchoring screening of defects interaction in a nematic liquid crystal 显示文摘 | BOGI A MARTINOT-LAGARDE P DOZOV I | 2002 | Physical Review Letters2002，89，22： | 1 |
| 12 | Two edge-bonded elastic wedges of differentmaterials and angles under surface tractions显示文摘 | BOGY D B | 1971 | Journal ofApplied Mechanics1971，38，2： | 1 |
| 13 | A generalized compressible Reynolds lubrication equation with bounded contact pressure显示文摘 | Wu L Bogy D B | 2001 | Physics of Fluids2001，13，8： | 1 |
| 14 | Stress Singularities at Interface Corners in Bounded Dissimilar Isotropic Elastic Materials显示文摘 | Bogy D B Wang K C | 1971 | International Journal of Solids and Structures1971，7，： | 1 |
| 15 | Characterization of diamond-like carbon films and their application as overcoats on thin-film media for magnetic recording显示文摘 | TSAI Hsiao-chu BOGY D B | 1987 | J Vac Sci Technol A1987，5，6： | 1 |
| 16 | Static friction coefficient model for metallic rough surfaces 显示文摘 | Chang W R Etsion I Bogy D B | 1988 | ASME Journal of Tribology1988，110，1： | 1 |
| 17 | Multidiseciplinary Approaches to the Pressure Ulcer Problem显示文摘 | Bogie K M Ho C H | 2007 | Ostomy Wound Manage2007，53，10： | 1 |
| 18 | Macrophage subsets and microglia in multiple sclerosis 显示文摘 | Bogie JFI Stinissen P Hendriks JJ | 2014 | Acta Neuropathol2014，128，2： | 1 |
| 19 | A Parametric Study of Head Disk Interface Instability due to Intermolecular Forces显示文摘 | Thornton B H Bogy D B | 2004 | IEEE Transaction on Magnetic2004，40，： | 1 |
| 20 | Effect of the hydrodynamic bearing on rotor/stator contact in a ring-type ultrasonic motor显示文摘 | Maeno T Bogy D B | 1992 | IEEE Transactions on Ultrasonics Ferroelectrics Frequency Control1992，39，6： | 1 |
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