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| 1 | 脊柱手术后患者外科手术部位感染及相关危险因素(英文)显示文摘目的外科手术部位感染(SSI)是脊柱手术后常见的并发症之一,与感染发病率增高,治疗时间延长,医疗费用增加,患者预后效果不良有着密不可分的关系。本研究的目的是探索某教学医院患者进行脊柱手术后发生SSI的现状与其相关危险因素。方法采用前瞻性队列研究方法,对2014年6月26日-11月30日该院所有脊柱手术患者进行目标性监测,以美国疾病控制与预防中心(CDC)颁布的指南作为SSI的诊断依据,通过床旁调查与出院后的检查发现SSI病例,使用标准化的数据收集脊柱手术患者术前,术中及术后资料。结果 2014年6月26日—11月30日共监测192例脊柱手术患者,其中7例(3.6%)发生了SSI。通过双变量分析的方法发现切口类型(污染/感染切口)、外科引流、输血与增加SSI风险的密切相关。在192例脊柱手术患者中,120例(62.5%)给予静脉使用预防性抗菌药物,使用周期为2.2(1~9)d,139例(72.4%)使用中成药。结论该研究有助于了解该教学医院脊柱手术后患者SSI发病率,亦为今后进行脊柱手术后患者发生SSI的研究提供有价值的信息。 | 王建聪 卢晓燕 Gunnar Aksel Bjune Hanne Merete Eriksen | 2017 | 中国感染控制杂志2017，16，1： | 18 |
| 2 | Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India显示文摘AIM:To investigate whether routinely measured clinical variables could aid in differentiating intestinal tuberculosis(ITB)from Crohn’s disease(CD).METHODS:ITB and CD patients were prospectively included at four South Indian medical centres from October 2009 to July 2012.Routine investigations included case history,physical examination,blood biochemistry,ileocolonoscopy and histopathological examination of biopsies.Patients were followed-up after 2 and 6 mo of treatment.The diagnosis of ITB or CD was re-evaluated after 2 mo of antituberculous chemotherapy or immune suppressive therapy respectively,based on improvement in signs,symptoms and laboratory variables.This study was considered to be an exploratory analysis.Clinical,endoscopic and histopathological features recorded at the time of inclusion were subject to univariate analyses.Disease variables with sufficient number of recordings and P<0.05 were entered into logistic regression models,adjusted for known confounders.Finally,we calculated the odds ratios with respective confidence intervals for variables associated with either ITB or CD.RESULTS:This study included 38 ITB and 37 CD patients.Overall,ITB patients had the lowest body mass index(19.6 vs 22.7,P=0.01)and more commonly reported weight loss(73%vs 38%,P<0.01),watery diarrhoea(64%vs 33%,P=0.01)and rural domicile(58%vs 35%,P<0.05).Endoscopy typically showed mucosal nodularity(17/31 vs 2/37,P<0.01)and histopathology more frequently showed granulomas(10/30vs 2/35,P<0.01).The CD patients more frequently reported malaise(87%vs 64%,P=0.03),nausea(84%vs 56%,P=0.01),pain in the right lower abdominal quadrant on examination(90%vs 54%,P<0.01)and urban domicile(65%vs 42%,P<0.05).In CD,endoscopy typically showed involvement of multiple intestinal segments(27/37 vs 9/31,P<0.01).Using logistic regression analysis we found weight loss and nodularity of the mucosa were independently associated with ITB,with adjusted odds ratios of 8.6(95%CI:2.1-35.6)and 18.9(95%CI:3.5-102.8)respectively.Right lower abdominal quadrant pain on examination and involvement of≥3 intestinal segments were independently associated with CD with adjusted odds ratios of 10.1(95%CI:2.0-51.3)and 5.9(95%CI:1.7-20.6),respectively.CONCLUSION:Weight loss and mucosal nodularity were associated with ITB.Abdominal pain and excessive intestinal involvement were associated with CD.ITB and CD were equally common. | Geir Larsson Thrivikrama Shenoy Ramalingom Ramasubramanian Leena Kondarappassery Balakumaran Milada Cvancarova Smstuen Gunnar Aksel Bjune Bjφrn Allan Moum | 2014 | World Journal of Gastroenterology2014，20，17： | 5 |
| 3 | Diabetes mellitus is associated with increased mortality during tuberculosis treatment:a prospective cohort study among tuberculosis patients in SouthEastern Amahra Region,Ethiopia显示文摘Background:There is growing evidence suggesting that diabetes mellitus(DM)affects disease presentation and treatment outcome in tuberculosis(TB)patients.This study aimed at investigating the role of DM on clinical presentations and treatment outcomes among newly diagnosed TB patients.Methods:A prospective cohort study was conducted in South-Eastern Amhara Region,Ethiopia from September 2013 till March 2015.Study subjects were consecutively recruited from 44 randomly selected health facilities in the study area.Participants were categorized into two patient groups,namely,patients with TB and DM(TBDM)and TB patients without DM(TBNDM).Findings on clinical presentations and treatment outcomes were compared between the two patient groups.Cox proportional hazard regression analysis was applied to identify factors associated with death.Results:Out of 1314 TB patients enrolled in the study,109(8.3%)had coexisting DM.TBDM comorbidity[adjusted hazard ratio(AHR)3.96;95%confidence interval(C.I.)(1.76–8.89)],and TB coinfection with human immunodeficiency virus(HIV)[AHR 2.59;95%C.I.(1.21–5.59)]were associated with increased death.TBDM and TBNDM patients did not show significant difference in clinical symptoms at baseline and during anti-TB treatment period.However,at the 2nd month of treatment,TBDM patients were more symptomatic compared to patients in the TBNDM group.Conclusions:The study showed that DM is associated with increased death during TB treatment.DM has no association with clinical presentation of TB except at the end of the intensive phase treatment.Routine screening of TB patients for DM is recommended for early diagnosis and treatment of patients with TBDM comorbidity. | Mahteme Haile Workneh Gunnar Aksel Bjune Solomon Abebe Yimer | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Circulating antibodies tolipoarabinomannan in relation to sputum microscopy,clinical fea-tures and urinary anti-lipoarabinomannan detection in pulmonarytuberculosis显示文摘 | Tessema TA Bjune G Hamasur B | 2002 | Scand J Infect Dis2002，34，2： | 1 |
| 5 | Assessing immunization data quality from routine reports in Mozambique 显示文摘 | Mavimbe JC Braa J Bjune G | 2005 | BMC public health2005，5，： | 1 |
| 6 | Failure analysis of drillstrings显示文摘 | MACDONALD K A BJUNE J V | 2007 | Engineering Failure Analysis2007，14，： | 1 |
| 7 | Perception and man- agement of tuberculosis symptoms in Addis Ababa, Ethio- pia 显示文摘 | Sagbakken M Frich J C Bjune G A | 2008 | Qual Health Res2008，18，10： | 1 |
| 8 | Failure analysis of drillstrings显示文摘 | MACDONALD K A BJUNE J V | 2007 | Engineering Failure Analysis2007，14，8： | 1 |
| 9 | Sensitivity and specificity of PCR for detection of Mycobacterium tuberculosis:a blind comparison study among seven laboratories 显示文摘 | Kolk A H J Bjune G | 1994 | J Clin Microbiol1994，32，： | 1 |
| 10 | An evaluation of the diagnostic value of clinical and radiological manifestations in patients attending the Addis Ababa tuberculosis centre显示文摘 | Tessema TA Bjune G Assefa G | 2001 | Scand J Infect Dis2001，33，： | 1 |
| 11 | A systematic review of delay in the diagnosis and treatment of tuberculosis显示文摘 | Storla DG YimerS Bjune GA | 2008 | BMC public health2008，，8： | 1 |
| 12 | Epidemic of tuberculosis in the former Soviet Union: social and biological reasons 显示文摘 | Toungoussova OS Bjune G Caugant DA | 2006 | Tuberculosis (Edinb)2006，86，1： | 1 |
| 13 | The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Gu6rin (BCG) vaccines: is there a link? 显示文摘 | Abebe F Bjune G | 2006 | Clin Exp Immunol2006，145，3： | 1 |
| 14 | Progress in serodiagnosis of Mycobacterium tuberculosis infection显示文摘 | Abebe F Holm-Hansen C Wiker HG Bjune G | 2007 | Scand J Immunol2007，66，23： | 1 |
| 15 | Failure analysis of drillstrings 显示文摘 | Macdonald K A Bjune J V | 2007 | Eng Failure Anal2007，30，14： | 1 |
| 16 | Diagnostic and treatment delay among pulmonary tuberculosis patients in Ethiopia: a cross sectional study显示文摘 | Yimer S Bjune G Alene G | 2005 | BMC Infect Dis2005，5，： | 1 |
| 17 | The emergence of Beijing family genotypes d Mycobacterium tuberculosis and low- level protection by bacilli Calmette-q Gufirin (BCG) vaccines: is there a link显示文摘 | Ahebe F Bjune G | 2006 | Clin Exp Im- munol2006，145，3： | 1 |
| 18 | Sensitivity and specificity of PCR for detection of Myeobacterium tuberculosis: a blind comparison study among seven laboratories显示文摘 | Noordhoek GT Kolk A HJ Bjune G | 1994 | Journal of Clinical Microbiology1994，32，2： | 1 |
| 19 | Diagnostic and treatment delay among pulmonary tuberculosis patients in Ethiopia:a crossseetional study 显示文摘 | Yimer S Bjune G Alene G | 2005 | BMC Infect Dis2005，5，： | 1 |
| 20 | Prevalence of pulmonary tuberculo- sis and associated risk factors in Eastern Ethiopian prisons 显示文摘 | Abebe DS Bjune G Ameni G | 2011 | Int J Tuberc Lung Dis2011，15，5： | 1 |
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