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| 1 | Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing显示文摘Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial infections.Accordingly,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic material.FESEM images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the substrate.The coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the specimens.They also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct cultivation.Copper conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture assay.Finally,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of S.aureus biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed. | Laura Ramos Rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini | 2021 | Bioactive Materials2021，6，5： | 2 |
| 2 | Candida parapsilosis keratitis following treatment of epithelial ingrowth after laser in situ keratomileusis显示文摘 | Solomon R Biser S A Donnenfeld E D | 2004 | Eye Contact Lens2004，30，2： | 1 |
| 3 | Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/dbmice显示文摘 | Szabo C Biser A Benko R | 2006 | Diabetes2006，55，11： | 1 |
| 4 | (Poly (ADP-Ribose) Polymerase Inhibitors Ameliorate Nephropathy of Type 2 Diabetic Leprdb/db Mice 显示文摘 | Szabo C Biser A Benko R | 2006 | Diabetes2006，55，11： | 1 |
| 5 | Slitlamp stretching of the corneal flap after laser in situ keratomilensis to reduce corneal striae 显示文摘 | Solomon R Donnenfeld ED Perry IID Doshi S Biser S | 2003 | J Cataract Refract Surg2003，29，7： | 1 |
| 6 | The role of osteopontin in the development of albuminuria 显示文摘 | Lorenzen J Shah R Biser A | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 7 | Flap folds after femtosecond LASIK显示文摘 | Biser SA Bloom AH' Donnenfeld ED | 2003 | Eye Contact Lens2003，29，4： | 1 |
| 8 | The role of osteopontin in the development of albuminuria显示文摘 | Lorenzen J Shah R Biser A | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 9 | Flap folds after femtosecond LASIK显示文摘 | Biser SA Bloom AH Donnenfeld ED | 2003 | Eye Contact Lens2003，29，4： | 1 |
| 10 | Flap folds after femtosecond LASIK显示文摘 | Biser SA Bloom AH Donnenfeld ED | 2003 | Eye Contact Lens2003，29，： | 1 |
| 11 | Buflomedil in arterial occulusive disease: Result of a controlled multicenter study 显示文摘 | Tnubestein C Balzer K Biser H | 1984 | Angiology1984，35，： | 1 |
| 12 | Conservative treatment of meibomian gland dysfunction 显示文摘 | Romero JM Biser SA Perry HD | 2004 | Eye Contact Lens2004，30，： | 1 |
| 13 | Flap folds after femtosecond LASIK显示文摘 | Biser SA Bloom AH Donnenfeld ED | 2003 | Eye Contact Lens2003，29，4： | 1 |
| 14 | Conservative treatment of meibomian gland dysfunction显示文摘 | Romero JM Biser SA Pen7 HD | 2004 | Eye Cantact Lens2004，30，： | 1 |
| 15 | The role of osteopontin in the development of albuminuria 显示文摘 | Lorenzen J Shah R Biser A | 2008 | J Am Sac Nephrol2008，，19： | 1 |
| 16 | The role of osteopontin in the development of albuminuria 显示文摘 | Lorenzen J Shah R Biser A | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 17 | Conservative treatment of meibomian gland dysfunction 显示文摘 | Romero JM Biser SA Perry HD | 2004 | Eye Contact Lens2004，30，： | 1 |
| 18 | Na + , K + ATPase alpha -subunit isoforrn distribution and abundance in guinea- pig longitudinal muscle/myenteric plexus after exposure to morphine 显示文摘 | Biser PS Thayne KA Fleming WW | 2002 | Brain Res2002，931，2： | 1 |
| 19 | Flop folds after femtoseeond LASIK显示文摘 | Biser SA Bloom AH Donnenfeld ED | 2003 | Eye Contaet Lens2003，29，4： | 1 |
| 20 | Relationship between perceived physical ability and indices of actual physical fitness显示文摘 | Thornton B Ryckman R M Robbins M A Donolli J & Biser G | 1987 | Journal of Sport Psychology1987，9，： | 1 |
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