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| 1 | Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats显示文摘Background: Haemonchosis is a major economic problem in goat production in humid, tropical and subtropical regions. The disease is caused by an abomasal nematode, Haemonchus contortus, which is highly pathogenic in small ruminants. The aim of this study was to identifying single-nucleotide polymorphisms(SNP) that were associated with fecal egg counts(FEC) and could be used as markers to identify resistance to H. contortus in goats.Results: Ten novel variants in the CI TA, ATP2 A3, HSPA8, STAT5 B, ESYT1, and SERPING1 genes were associated with FEC in goats with a nominal significance level of P < 0.05. Two missense mutation in the exon region of the caprine CI TA gene resulted in replacement of arginine with cysteine at position 9473550(R9473550 C) and aspartic acid with glutamic acid at position 9473870(D9473870 E). Chinese goat breeds had significantly higher FEC than Bangladeshi goat breeds within their respective genotypes. Polymorphism information content(PIC), effective al ele number(Ne), and heterozygosity(He)were greatest for the STAT5 B197A > G SNP locus in al goat breeds. Pairwise coefficients of linkage disequilibrium(D′, r2)revealed complete LD(r2= 1) between significant SNP polymorphisms in CI TA and SERPING1 and strong LD(r2= 0.93 and0.98) between polymorphisms in HSPA8 and ATP2 A3, respectively. Correlation coefficient(r) between FEC and body weight(BW) was significantly positive(r = 0.56***, P < 0.001) but that between FEC and packed cel volume(PCV) was negatively significant(r =-0.47**, P < 0.01) in the total population of goats. On the other hand, correlation coefficient(r)between BW and PCV was not significant in total population of goats. Association analysis revealed that haplotypes within ATP2 A3, HSPA8, and SERPING1 were significantly associated with FEC. Quantitative real-time PCR revealed that the relative expression of m RNA was higher(P < 0.001) for resistant, compared to susceptible, groups of goats for al candidate genes except CI TA.Conclusions: This study identified SNP markers that can potential y be used in marker-assisted selection programs to develop goat breeds that are resistant to H. contortus. | Mahmuda Bilkis Bintee Alam Abdullah Ibne Omar Md.Omar Faruque David Russell Notter Kathiravan Periasamy Md.Motahar Hussain Mondal Md.Jalal Uddin Sarder Md.Shamsuddin Jianhua Cao Xiaoyong Du Zhenyang Wu Shuhong Zhao | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
| 2 | The Amplatzer duct occluder: Experience in 209 patients 显示文摘 | BILKIS A A ALWI M HASRI S | 2001 | J Am Coil Cardiol2001，37，1： | 1 |
| 3 | Predictors of failed closure of patent ductus arteriosus with indomethacin 显示文摘 | Boo NY Mohd-Amin I Bilkis AA | 2006 | Singapore Med J2006，47，9： | 1 |
| 4 | The Amplatzer duct occluder: experience in 209 patients显示文摘 | BILKIS A A ALWI M HASRI S | 2001 | J Am Coil Cardiol2001，37，1： | 1 |
| 5 | The Amplatzer duct occluder: experience in 209 patients显示文摘 | Bilkis AA Alwi M Hasri S | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 6 | Predictors of failed closure of patent ductus arteriosus with indomethacin显示文摘 | Boo NY Mohd-Amin I Bilkis AA | 2006 | Singapore Med J2006，47，9： | 1 |
| 7 | Glycosylation of resveratrol protects it from enzymic oxidation显示文摘 | Regev-Shoshani G Shoseyov O Bilkis I | 2003 | Biochem J2003，374，1： | 1 |
| 8 | Acute renal failure in typical Kawasaki disease显示文摘 | Bonany PJ Bilkis MD Gallo G | 2002 | Pediatr Nephrol2002，17，5： | 1 |
| 9 | Sorption-desorption behavior of triazine and phenylurea herbicides in Kishon river sediments 显示文摘 | Chefetz B Bilkis Y I Polubesova T | 2004 | Water Research2004，38，20： | 1 |
| 10 | The Amplatzer Duct Occluder:Experience in 209 Patients显示文摘 | BILKIS A A ALW I M HASRI S | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
| 11 | The Amplatzer duct occluder: experience in 209 patients显示文摘 | Bilkis AA Alwi M Hasri S | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
| 12 | Acute renal failure in typical Kawasaki disease显示文摘 | Bonany PJ Bilkis MD Gallo G | 2002 | Pediatr Nephrol2002，17，5： | 1 |
| 13 | Prevalence and anti- microbial resistance of methicillin resistant Staphylococ- cus epidermidis isolated at Mymensingh Medical College Hospital显示文摘 | Haque N Bari MS Bilkis L | 2010 | Mymensingh Med J2010，19，2： | 1 |
| 14 | Comparative study between rectally administered misoprostol as a prophylaxis versus conventional intramuscular oxytocin in post partum hemorrhage显示文摘 | Haque N Bilkis L Haque N | 2009 | Mymensingh Medical Journal2009，18，1： | 1 |
| 15 | The Amplatzer duc occluder: Experience in 209 patients显示文摘 | BILKIS A A AIWI M HASRI S | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 16 | The amplatzer duet oeduder: ex- perience in209 patients 显示文摘 | Bilkis AA /kiwi M Hasri S | 2001 | J Am Coil Cardiol2001，37，： | 1 |
| 17 | The Amplatzer duct occluder; experience in 209 patients 显示文摘 | Bilkis AA Alwi M Hasri S | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
| 18 | The Amplatzer duct occluder:experience in 209 patients显示文摘 | BILKIS A A ALWI M HAIFA S | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
| 19 | The Amplatzer duet occluder:experience in 209 patients显示文摘 | ALWI M HASRI S | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
| 20 | Pulmonary atresia with intact ventricular septum percutaneous radiofrequency assisted valvotomy and balloon dilation versus surgical valvotomy and blaloek taussig shunt显示文摘 | Alwi M Geetha K Bilkis AA | 2000 | J Am Coll Cardiol2000，35，2： | 1 |
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