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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Precise Point to Point Positioning Control of Flexible Structure显示文摘 | Bhat S P Miu D K | 1990 | ASME J of Dynamic System Measurement and Control1990，112，4： | 1 |
| 3 | Influence of fibrolytic enzymes on the hydrolysis and fermentation of pure cellulose and xylan by mixed ruminal microorganisms in vitro显示文摘 | Colombatto D Mould F L Bhat M K | 2003 | Journal of Animal Science2003，81，： | 1 |
| 4 | Finite-time stability of continuous autonomous systems显示文摘 | Bhat S P Bernstein D S | 2000 | SIAM Journal of Control and Optimization2000，38，8： | 1 |
| 5 | Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions显示文摘 | Miller A G Smith D G Bhat M | 2006 | J Biol Chem2006，281，11： | 1 |
| 6 | Geometric homogeneity with applications to finite time stability显示文摘 | Bhat S Bernstein D | 2005 | Mathematics of Control Signals and Systems2005，17，2： | 1 |
| 7 | Finite-time stability of continuous autonomous systems显示文摘 | BHAT BERNSTEIN D | 2000 | SIAM Journal of Control and Optimization2000，38，3： | 1 |
| 8 | Continuous finite-time stabilization of the translational and rotational double integrators显示文摘 | Bhat S P Bernstein D S | 1998 | IEEE Transactions on Automatic Control1998，43，5： | 1 |
| 9 | Shear characteristics of soil -gravel mixtures 显示文摘 | Doddiah D Bhat H S Somasekhar P V | 1969 | Journal of the Indian National Society of Soil Mechanicsand Foundations Engineering1969，8，1： | 1 |
| 10 | Continuous finite-time stabilization of the translational and rotational double integrators 显示文摘 | Bhat S P Bernstein D S | 1998 | IEEE Transactions on Automatic Control1998，43，5： | 1 |
| 11 | Aromatase inhibitors from Broussonetia papyrifera 显示文摘 | Lee D Bhat K P L Fong H H S | 2001 | Journal of Natural Products2001，64，： | 1 |
| 12 | Geometric homogeneity with applications to finite-time stability显示文摘 | Bhat S P Bernstein D S | 2005 | Mathematics of Control Signals and Systems2005，17，2： | 1 |
| 13 | Geometric homogeneity with applications to finite-time stability显示文摘 | BHAT BERNSTEIN D | 2005 | Math Control Signals Systems2005，17，： | 1 |
| 14 | Lyapunov-based exponential tracking control of a hypersonic aircraft with aerothermoelastic effects显示文摘 | Wilcox Z D Mackunis W Bhat S | 2010 | Journal of Guidance Control and Dynamics2010，33，4： | 1 |
| 15 | Lyapunov-based ex- ponential tracking control of a hypersonic aircraft with aerothermoe- lastic effects 显示文摘 | WILCOX Z D MACKUNIS W BHAT S | 2010 | Journal of Guidance Control and Dynamics2010，33，4： | 1 |
| 16 | Finite-time stability of continuous autonomous systems显示文摘 | Bhat S P Bernstein D S | 2000 | SIAM Journal of Control and Optimization2000，38，3： | 1 |
| 17 | Finite-time stability of continuous autonomous systems 显示文摘 | Bhat S P Bernstein D S | 2000 | SIAM Journal on Control and Optimization2000，38，3： | 1 |
| 18 | Prevalence of human papillomavirus types and phylogenetic analysis of hpv-16 11 variants from southern india 显示文摘 | Kabekkodu SP Bhat S Pandey D | 2015 | Asian Pacific Journal of Cancer Preven- tion2015，16，5： | 1 |
| 19 | Papillary glioneuro- nal tumor-evidence of stem cell origin with biphenotypic differenti-ation显示文摘 | Govindan A Mahadevan A Bhat D I | 2009 | J Neurooncol2009，95，1： | 1 |
| 20 | Hepatitis B virus translocates across atrophoblastic barrier显示文摘 | Bhat P Anderson D A | 2007 | J Virol2007，81，13： | 1 |
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