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| 1 | Pyrrolidine dithiocarbamate protects pancreatic β-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats显示文摘Pyrrolidine dithiocarbamate (PDTC ) 罐头降低血葡萄糖水平并且在糖尿病的 rats.However 改进胰岛素敏感,在糖尿病的老鼠位于 PDTC 治疗的这效果下面的机制仍然保持不明确。在这研究,我们 PDTC 与 experimentaltype 在老鼠对胰腺的小岛房间的氧化损坏由授与保护的 evaluatedthe 机制 2 糖尿病 mellitus (DM ) 。在老鼠的 DM 被伴有单个 intraperitoneal (i.p ) 的长期的高脂肪的饮食得到 streptozotocin 的低剂量的注射。在 PDTC (50 mg/kg/day i.p ) 的一个 7 天的政府以后,血 glucoselevels 被测量,胰腺的纸巾为各种各样的生物化学、酶的 activitiesusing immunohistochemistry, immunofluorescence,和西方的污点技术的决心是镇定的。apoptotic 的百分比胰腺的小岛房间被流动 cytometry 检测。结果证明糖尿病的老鼠提高了血葡萄糖层次和 insulinresistance,随 malondialdehyde 内容, nitrotyrosine 生产,和可诱导的氮的 oxidesynthase 表示的增加伴随了。在 superoxide dismutase 和谷胱甘肽 peroxidase 活动的减少也在 DM 老鼠被观察,与提高的房间 apoptosis 达到顶点。PDTC 处理显著地减少了氧化损坏和房间 apoptosis,并且也通过下面调整的 FoxO1 acetylation 和建议的起来调整的原子 PDX-1 level.These 数据增加了胰岛素生产那 PDTC 能保护小岛房间免受氧化损坏的伤害并且在一个 DM 老鼠模型通过 regulationof PDX-1 和 FoxO1 改进胰岛素生产。 | Haiyan Ding Tienian Zhu Xiaomei Yin Jiankun Liu Lizhong Zhang Michel Bemier Ruijing Zhao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 4 |
| 2 | Antioxidant properties of hydroxyl flavones 显示文摘 | Cotellen N Bemier J L Catteau J P | 1996 | Free Radical Biology & Medicine1996，20，1： | 1 |
| 3 | Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice显示文摘 | LORD-GRIGNON J ABDOUH M BEMIER G | 2006 | Gene Expression Patterns2006，6，8： | 1 |
| 4 | Mechanical Properties of Reactive Powder Concretes显示文摘 | Dugat J Roux N Bemier G | 1996 | Materials and Structures1996，29，5： | 1 |
| 5 | Uncertainty in the design length calculation for vert -ical ground heat exchangers显示文摘 | M A Bemier | 2002 | ASHRAE Transactions2002，，： | 1 |
| 6 | Comparison of ribosonmal DNA length and restficition site polymophisms in Gremmeniella and Ascocalyx isolates显示文摘 | Bemier L Hamelin R C Ouellette G B | 1994 | Applied and Environ-mental Microbiology1994，60，： | 1 |
| 7 | Diagnostic crite- ria for respiratory chain disorders in adults and children 显示文摘 | Bemier FP Boneh A Dennett X | 2002 | Neurology2002，59，9： | 1 |
| 8 | Bayesian change point analysis in hydrometeorological time series显示文摘 | Perreault L Bemier J Parent E | 2000 | Journal of Hydrology2000，235，34： | 1 |
| 9 | Large-scale production of single-walled carbon nanotubes by the electric-arc technique显示文摘 | Joumet C Maser W K Bemier P | 1997 | Nature1997，388，： | 1 |
| 10 | A fast and accurate face detection based on neural network 显示文摘 | Eraud R F Bemier O J Viallet J E | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，23，1： | 1 |
| 11 | A multiple load aggregation algorithm for annual hourly simulations of GCHP systems显示文摘 | Bemier M A Pinel P Labib R | 2004 | HVAC and R Research2004，10，4： | 1 |
| 12 | Circulating adiponectin levels increse in rats on caloric restriction: the potential for insulin sensitization显示文摘 | Zhu M Miura J Lu L X Bemier M | 2004 | Exp Gerontol2004，39，7： | 1 |
| 13 | Antioxidant properties of hydroxyl-flavones 显示文摘 | CETELLE N BEMIER J CATTEALL J P | 1996 | Free Radical & Medicine1996，20，1： | 1 |
| 14 | A quarter century of progress on the early detection and treatment of autism spectrum disorder显示文摘 | Dawson G Bemier R | 2013 | Dev Psy-chopathol2013，25，4： | 1 |
| 15 | Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition and maintenance of functional activities 显示文摘 | Landry J Bemier D | 1985 | J Cell Biol1985，101，： | 1 |
| 16 | Effects of cortisolon food intake, growth, and forebrain neuropeptide Y and corticotropin - releasing factor gene expression in goldfish显示文摘 | Bemier N J Bedard N Richard E | 2004 | Gen Comp Endocrinol2004，135，2： | 1 |
| 17 | Antioxidant properties of hydroxyl fiavones 显示文摘 | COTELLE N BEMIER J L CATTEAU J P | 1996 | Free Radical Biology Medicine1996，20，1： | 1 |
| 18 | Physiological singals that induce flowering 显示文摘 | Bemier G Havelange A Houssa C | 1993 | Plant Ce111993，，5： | 1 |
| 19 | Coupling of geothermal heat pumps with thermal solar collectors using double U-tube boreholes with two independent circuits 显示文摘 | Parham Eslami-nejad Michel Bemier | 2011 | Applied Thermal Engineering2011，31，： | 1 |
| 20 | Cetuximab combined with radiotherapy: an alternative to cbemoradiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck显示文摘 | Bemier J Schneider D | 2007 | Eur J Cancer2007，43，1： | 1 |
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