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| 1 | Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis显示文摘AIM: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). METHODS: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. RESULTS: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. CONCLUSION: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative. | Edda Battaglia Gabrio Bassotti Graziella Bellone Luca Dughera Anna Maria Serra Luigi Chiusa Alessandro Repici Pierroberto Mioli Giorgio Emanuelli | 2006 | World Journal of Gastroenterology2006，12，38： | 20 |
| 2 | Ⅱ型表皮生长因子受体(HER2/neu)过度表达的种族差异:子宫浆液性乳头状癌的主要预后指标 | Santin A.D. Bellone S. Siegel E.R. 朱国栋 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，7： | 2 |
| 3 | 采用HPV16/18型E7肽冲击的树突状细胞免疫复发性难治型宫颈癌显示文摘Objective. To evaluate the potential of human papillomavirus (HPV) type 16 and 18 E7 antigen-loaded autologous dendritic cells (DC) as a therapeutic cellular vaccine in a case series of cervical cancer patients harboring recurrent/metastatic disease refractory to standard treatment modalities. Methods. Autologous monocyte-derived DC were pulsed with recombinant HPV16 E7 or HPV18 E7 oncoproteins and administered to 4 cervical cancer patients. Vaccinations were followed by subcutaneous administration twice daily of low doses of human recombinant interleukin- 2 (1 × 106 IU/m2) from day 3 to day 7. Safety, toxicity, delayed type hypersensitivity reactions (DTH), clinical responses, and induction of serological and cellular immunity against HPV16/18 E7 were monitored. Results. The vaccine was well- tolerated in all patients and no local or systemic side effects or toxicity were recorded. Three out of four patients were found to be significantly immunocompromised before starting the vaccination treatment, as assessed by DTH with a panel of recall antigens. Specific humoral and cellular CD4+ T cell responses to the E7 vaccine were detected in 2 patients, as detected by ELISA and by IFN- γ ELISpot assays, respectively. Increased numbers of E7- specific IFN- γ secreting CD8+ T cells were detected in all patients after vaccination. Swelling and induration (i.e., a positive DTH response) to the intradermal injection of HPV E7 oncoprotein and/or irradiated autologous tumor cells were detected in two patients after six vaccinations. No objective clinical responses were observed. However, both patients who developed a positive DTH to the vaccine experienced a slow tumor progression (i.e., 13 months survival)while DTH unresponsive patients died within 5 months from the beginning of therapy. Conclusions. Autologous DC pulsed with HPV16/18 E7 proteins can induce systemic B and T cell responses in patients unresponsive to standard treatment modalities. However, treatment-induced immunosuppression may impose severe limitations on the efficacy of active vaccination strategies in late stage cervical cancer patients. DC-based vaccination trials are warranted in immunocompetent cervical cancer patients with early stage disease and/or limited tumor burden, and at significant risk for tumor recurrence or disease progression. | Santin A.D. Bellone S. Palmieri M. 李奎 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 2 |
| 4 | Restoration of tumor specific human leukocyte antigens class Ⅰ -restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer 显示文摘 | Santin AD Bellone S Pahnieri M | 2004 | Int J Gynecol Cancer2004，14，1： | 1 |
| 5 | Percutaneous transfemoral embolization of an indirect carotid-cavernous fistula with cortical venous access to the cavernous sinus显示文摘 | Liu AY Adler JR | 1999 | J Neurosurg1999，90，5： | 1 |
| 6 | Chest physical therapy in patients with acute exacerbation of chronic bronchitis:effectiveness of three methods显示文摘 | Lascio II R Raschi S | 2000 | Arch Phys Med Rehabil2000，81，5： | 1 |
| 7 | Estrogen inhibits IL-1 and TNF gene expression in transfected murine macrophagic cells显示文摘 | Kimble RB Srivastava S Bellone C | 1996 | J Bone Miner Res1996，11，1： | 1 |
| 8 | The novel serine protease tumor-associated differentially expressed gene-14 ( KLK8/ Neuropsin/ Ovasin) is highly overexpressed in cervical cancer显示文摘 | Cane S Bignotti E Bellone S | 2004 | Am J Obstet Gynecol2004，190，1： | 1 |
| 9 | Trade-offs associated with axillary lymph node dissection with breast irradiation versus breast irradiation alone in patients with a positive sentinel node in relation to the risk of non-sentinel node involvement: implications of ACOSOG Z0011 显示文摘 | Krishnan MS Recht A Bellon JR | 2013 | Breast Cancer Res Treat2013，138，1： | 1 |
| 10 | Use of 14C l-sodium bicarbonate/urea to measure total energy expenditure in overweight men and women before and after low calorie diet induced weight loss 显示文摘 | Luscombe ND Tsopelas C Bellon M | 2006 | Asia Pac 3 Clin Nutr2006，15，3： | 1 |
| 11 | A hidden Markov model for downscaling synoptic atmospheric patterns to precipitation amounts显示文摘 | Bellone E Hughes J P Guttorp P | 2000 | Climate Research2000，15，1： | 1 |
| 12 | Induction of ovarian tumor-specific CD8^ + cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells 显示文摘 | Santin AD Bellone S Ravaggi A | 2000 | Obstet Gynecol2000，96，3： | 1 |
| 13 | Short-term effects of expiration under positive pressure in patientswith acute exacerbation of chronic obstructive pulmonary disease and mild acidosis requiring non-invasive positive pressure ventilation显示文摘 | Spagnolatti L Massobrio M | 2002 | Intensive Care Med2002，28，5： | 1 |
| 14 | Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not显示文摘 | Gecz J Shaw M A Bellon J R | 2003 | Gene2003，320，： | 1 |
| 15 | Experimental study of the antithrombogenic behavior of Dacron vascular grafts coated with hydrophilic acrylic copolymers bearing salicylic acid residues显示文摘 | Julio San Roman Julia Bujan Bellon Juan M | 1996 | J Biomed Mater Res1996，32，1： | 1 |
| 16 | Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy显示文摘 | Spirito P Bellone P Harris KM | 2000 | N Engl J Med2000，342，24： | 1 |
| 17 | Overexpre- ssion of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas 显示文摘 | Santin AD Bellone S Siegel ER | 2007 | Clin Cancer Res2007，13，11： | 1 |
| 18 | An analytical model of the switching behavior of 4H-SiC PIN diodes from arbitrary injection conditions显示文摘 | Bellone S Della F Benedetto D | 2012 | IEEE Transactions on Power Electronics2012，27，3： | 1 |
| 19 | Preserved immune system in long-term asymptomatic vertically HIV-1 infected children显示文摘 | Resino S Correa R Bellon J M | 2003 | Clin Exp Immunol2003，132，： | 1 |
| 20 | Overexpression of Claudia-3 and claudin-4 receptors in uterine serous papillary carcinoma:novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE)显示文摘 | Santin AD Bellone S Marizzoni M | 2007 | Cancer2007，109，7： | 1 |
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