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1核因子-κB是癌症治疗的好靶点吗?希望和缺陷显示文摘核因子κB(NF-κB)转录因子在许多生理过程中,如固有及获得性免疫应答、细胞增殖、细胞死亡和炎症,都起重要作用。目前已很清楚,NF-κB和控制其活性的信号通路的调节异常与癌症的发生发展以及患者对化疗和放疗产生耐受性有关。本文综述了NF-κB与癌症的关系、以NF-κB为靶点的癌症治疗潜能和益处以及这种治疗可能引发的并发症和缺陷。姜娜 辛文妤 陆丽娜 Baud V Karin M 2009国际药学研究杂志2009,36,4:9
2Final Results and Recommendations of the Last 10 Years IGCP 572 and 630 Field Workshops in South Turkey, Oman, India(Kashmir) and Armenia显示文摘Being involved in the organization of IGCP 572 field workshops in Turkey(2009), in Oman(2010), as in the following IGCP 630 field workshops in Kashmir(India, 2014) and in Armenia(2017), I co-wrote for each of them detailed guidebooks and extended reports that can be found and downloaded from Research Gate website. This paper summarizes the final results obtained by IGCP 572 and 630 members from these four important field workshop sites in the past 10 years, and also attempts to make recommendations for future studies based on these unique localities surrounding the Tethys Ocean. The first field workshop of IGCP 572 was organized in South Turkey in September, 2009, with the logistical support of Dr. Erdal Kosun from the Antalya University. Following the South Turkey field workshop, eight important papers have been published and concerned the well-preserved Permian-Triassic boundary(PTB) microbialites and their ecosystems(including ostracodes, brachiopods, and many of other clades). The 3 rd IGCP 572 annual field workshop was held during February, 2010 in the Sultanate of Oman, with Dr. Michaela Bernecker and the deep support from the Gu Tech University in Muscat. More than 15 papers have derived from the P-Tr successions that IGCP 572 members have investigated during this workshop, including the first study on oceanic acidification based on Boron isotopes. New paleontological studies are still on progress, and concern the Smithian ammonoids, Lower Triassic shark teeth and dental remains as well as basal Triassic conodonts, crinoids and ammonoids. The 1 st IGCP 630 annual field workshop was held during November, 2014 in Srinagar, Kashmir, and North India, with the helpful assistance of Prof. Ghulam Bhat from Jammu University. This meeting renewed studies on the classic Guryul Ravine and adjacent P-Tr boundary sections in that region, with new geochemical works on carbon isotopes and pyrite framboids as well as a detailed Induan conodont taxonomy and zonation. Other new paleontological works concern the palynology of the Guryul Ravine Section as some well-preserved organic eukariotic protist(thecamoebians) that cross without damage the PTB. Lilit Sahakyan, Aymon Baud, and Zhong-Qiang Chen organized the 5 th IGCP 630 annual conference and field workshop in Armenia on October 8–14, 2017. Several PTB and Lower Triassic sections have been systematically sampled for biogeochemical and geobiological studies. These Armenian sections provide unique paleoenvironmental settings that have the longest record, from Griesbachian to Dienerian, of microbial proliferation following the P-Tr mass extinction in the world. The basal Triassic giant sponge-microbial build-ups are encouraging more comprehensive studies on metazoan-microbial reef developments after the greatest extinction event.Aymon Baud 2018Journal of Earth Science2018,29,4:3
3Time-dependent cracking and brittle creep in crustal rocks: A review显示文摘N. Brantut M.J. Heap P.G. Meredith P. Baud 2013Journal of Structural Geology2013,,:3
4Characteristics of patients with dual infection by hepatitis B and C viruses显示文摘Jean-Pierre Zarski Benoit Bohn Anne Bastie Jean-Michel Pawlotsky Maryline Baud Frédérique Bost-Bezeaux Jeanne Tran van Nhieu Jean-Marie Seigneurin Catherine Buffet Daniel Dhumeaux 1998Journal of Hepatology1998,,1:2
5Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature显示文摘T. Van Mieghem A. Al‐Ibrahim J. Deprest L. Lewi J. C. Langer D. Baud K. O’Brien R. Beecroft R. Chaturvedi E. Jaeggi J. Fish G. Ryan 2014Ultrasound Obstet Gynecol2014,,6:2
6Prenatal ischemia and white matter damage in rats 显示文摘Olivier P Baud O Evrard P 2005Neuropathol Exp Neurol2005,64,11:1
7Influence of the temperature on the properties of sputtered titanium oxide films显示文摘Ben Amor S Guedri L Baud G 2003Materials Chemistry and Physics2003,77,3:1
8Characterization of Zireonia Films Deposited by RF Magnetron Sputtering 显示文摘Ben Amor S Rogier B Baud G 1998Materials Science and Engineering: B1998,7,1:1
9Follow up studies on therespiratory pattern and total cholinesterase activities in dichlorvos-poisoned rats显示文摘Duarte T Martin C Baud F Jf 2012Toxicoly Lett2012,213,2:1
10Toxicokinetics of paraquat in humans 显示文摘Houze P Baud FJ Mouy R 1990Hum Exp Toxicol1990,9,1:1
11Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls显示文摘Baud V Karin M 2009Nat Rev Drug Discov2009,8,1:1
12Structural and optical properties of sputtered ZnO films显示文摘BACHARI E M BAUD G BEN AMOR S JACQUET M 1999Thin Solid Films1999,348,12:1
13Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain 显示文摘Baud O Fayol L Gressens P 2003J Comp Neurol2003,465,3:1
14Compaction localization in porous sandstones: spatial evolution of damage and acoustic emission activity显示文摘Patrick Baud Emmanuelle Klein Teng-fong Wong 2003Journal of Structural Geology2003,,4:1
15An integrated overview of seed development in Arabidopsis thaliana eeotype WS 显示文摘Baud S Boutin J P Miquel M 2002Plant Physiol Biochem2002,40,:1
16Current recommendations for treatment toxic alcohol poisonings显示文摘 Borron SW Baud FJ 2005Intensiv Care Med2005,31,2:1
17On Image Denoising Method显示文摘Baudes A Coll B Morel J M 2005SIAM Multiscale Modeling and Simulation2005,4,2:1
18Evaluation of abdominal pain in Henoch-Schonlein syndrome by high frequency ultrasound显示文摘Couture A Veyrac C Baud C 1992Pediatr Radiol1992,22,:1
19Helicobacter pylori initi- ates a mesenchymal transition through ZEB1 in gastric epithelial cells显示文摘BAUD J VARON C CHABAS S 2013PIoS One2013,8,60:1
20The brittle-ductile transition in porous rock:A review显示文摘WONG T BAUD P 2012Journal of Structural Geology2012,,:1
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