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| 1 | 射血分数保留的心力衰竭患者的不同肥胖表型显示文摘射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)是一种具有多种临床表现的综合征。将病理生理表型相同的患者进行分类,可以使他们得到更好的针对性治疗。在HFpEF患者中,肥胖这一症状非常常见,可引发多种心血管效应,这表明可以根据肥胖对患者进行表型分类。 | 刘莉 叶鹏 Obokata M Reddy YNV Pislaru SV Melenovsky V Borlaug BA | 2017 | 中华高血压杂志2017，25，9： | 13 |
| 2 | 射血分数保留的心力衰竭患者动脉硬化与运动的相关性显示文摘人类衰老以主动脉僵硬度增加为特征,通过降低动脉顺应性和增强收缩期波反射造成收缩期高血压。老年、高血压和肥胖是射血分数保留的心力衰竭(heart failure with preserved ejection fraction, HFpEF)发生发展最大的影响因素. | Reddy YNV Andersen MJ Obokata M Koepp KE Kane GC Melenovsky V Olson TP Borlaug BA 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 10 |
| 3 | Rates and risk factors for suicidal ideation,suicide attempts and suicide deaths in persons with HIV:a systematic review and meta-analysis显示文摘Background People living with HIV/AIDS(PLWHA)must contend with a significant burden of disease.However,current studies of this demographic have yielded wide variations in the incidence of suicidality(defined as suicidal ideation,suicide attempt and suicide deaths).Aims This systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in PLWHA.Methods Publications were identified from PubMed(MEDLINE),SCOPUS,OVID(MEDLINE),Joanna Briggs Institute EBP and Cochrane Library databases(from inception to before 1 February 2020).The search strategy included a combination of Medical Subject Headings associated with suicide and HIV.Researchers independently screened records,extracted outcome measures and assessed study quality.Data were pooled using a random-effects model.Subgroup and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of heterogeneity.Main outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide attempt.Results A total of 185199 PLWHA were identified from 40 studies(12 cohorts,27 cross-sectional and 1 nested case-control).The overall incidence of suicide completion in PLWHA was 10.2/1000 persons(95%CI:4.5 to 23.1),translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 persons.The lifetime prevalence of suicide attempts was 158.3/1000 persons(95%CI:106.9 to 228.2)and of suicidal ideation was 228.3/1000 persons(95%CI:150.8 to 330.1).Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease(AIDS),the risk of suicide completion increased by 34 per 1000 persons.The quality of evidence by Grading of Recommendations,Assessment,Development and Evaluations for the suicide deaths was graded as‘moderate’quality.Conclusions The risk of suicide death is 100-fold higher in people living with HIV than in the general population.Lifetime incidence of suicidal ideation and attempts are substantially high.Suicide risk assessments should be a priority in PLWHA,especially for those with more advanced disease. | Matt Pelton Matt Ciarletta Holly Wisnousky Nicholas Lazzara Monica Manglani Djibril M Ba Vernon M Chinchillli Ping Du Anna E Ssentongo Paddy Ssentongo | 2021 | General Psychiatry2021，34，2： | 3 |
| 4 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 5 | Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination显示文摘DNA 双海滨裂缝(DSB ) 是高度细胞毒素的损害并且如果,形成主要威胁到染色体稳定性不适当地修理了。我们和其它以前证明了导致 DSB 的小 RNA (diRNAs ) 的一个班在 DSB 地点附近从序列被生产。DiRNAs 与 Argonaute 被联系(以前) 蛋白质和戏在 DSB 修理的一个重要角色,不过,他们通过行动的机制仍然保持不清楚。这里,我们报导在 DSB 修理的 diRNAs 的角色被限制由相应再结合(HR ) 修理并且它明确地在哺乳动物的房间依靠受动器蛋白质 Ago2。有趣地,我们证明 Ago2 与 Rad51 形成建筑群并且相互作用在与电离对待的房间被提高放射。我们证明在 DSB 地点和 HR 修理的 Rad51 累积取决于催化活动和 Ago2 的小 RNA 有约束力的能力。相反,象装载的 RPA 和 Mre11 一样的 DSB 切除术由 Ago2 或 Dicer 弄空是未受影响的,建议 Ago2 很多半在调停直接工作在 DSB 的 Rad51 累积。一起拿,我们的调查结果建议由 diRNAs 指导了那, Ago2 能在 DSB 支持 Rad51 招募或保留由 HR 便于修理。 | Min Gao Wei Wei Ming-Ming Li Yong-Sheng Wu Zhaoqing Ba Kang-Xuan Jin Miao-Miao Li You-Qi Liao Samir Adhikari Zechen Chong Ting Zhang Cai-Xia Guo Tie-shah Tang Bing-Tao Zhu Xing-Zhi Xu Niels Mailand Yun-Gui Yang Yijun Qi Jannie M Rendtlew Danielsen | 2014 | Cell Research2014，24，5： | 3 |
| 6 | Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculoma显示文摘 | Wasay M Kheleani BA Moolani MK | 2003 | J Neuroimaging2003，13，3： | 2 |
| 7 | Acute effects of smoking on diastolic function in healthy participants: studies by conventional Doppler echocardiography and Doppler tissue imaging 显示文摘 | Alam M Samad BA WardeU J | 2002 | J Am Soc Echocardiogr2002，15，102： | 1 |
| 8 | Principles of teaching evidence - based medicine显示文摘 | Petrisor BA Bhandari M | 2006 | Injury2006，37，4： | 1 |
| 9 | Burn scar revision on the face显示文摘 | De Souza BA Adlard R Shibu M | 2002 | Dermatol Surg2002，28，8： | 1 |
| 10 | Depot medroxyprogesterone acetate,oral contraceptives and bone mineral density in a cohort of adolescent girls 显示文摘 | Cromer BA Stager M Bonny A et' al | 2004 | J Adolesc Health2004，35，6： | 1 |
| 11 | Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation 显示文摘 | Suo Z Wu M Citron BA | 2003 | JBiolChem2003，278，31： | 1 |
| 12 | The use of carboplatin and paclitaxel withdaily radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck显示文摘 | Suntharalingam M Haas ML Conley BA | 2000 | Int J Radiat Oncol Biol Phys2000，47，1： | 1 |
| 13 | Le Fort Ⅲ advancement with gradual distraction using internal devices显示文摘 | Chin M Toth BA | 1997 | Plast Reconstr Surg1997，100，4： | 1 |
| 14 | Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators显示文摘 | Overhaus M Moore BA Barbato JE | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，4： | 1 |
| 15 | Urinary tissue factor levels in patients with bladder and prostate cancer显示文摘 | Lwaleed BA Francis JL Chisholm M | 2000 | Eur J Surg Oncol2000，26，： | 1 |
| 16 | Progression of HIV infec- tion and mortality by hepatitis C infection in patients with haemophilia over 20 years 显示文摘 | Quintana M Del Amo J Ba'asa A | 2003 | Haemophilia2003，，9： | 1 |
| 17 | Nurses~erceptions of the liverpool care path- way for the dying patient in the acute hospital setting显示文摘 | Jack BA Gambles M Murphy D | 2003 | Int J Palliat Nurs2003，9，9： | 1 |
| 18 | Impact of tumor size and tracer uptake heterogeneity in (18)F-FDG PET and CT non- small cell lung cancer tumor delineation显示文摘 | Hatt M Cheze-le RC van BA | 2011 | J Nucl Med2011，52，11： | 1 |
| 19 | Treatment of acute midshaft clavicle fractures: systematic review of 2144 frac tures;on behalf of the Evidence Based Orthopaedic Trauma Working Group显示文摘 | Zlowodzki M Zelle BA Cole PA | 2009 | J Orthop Trauma2009，19，7： | 1 |
| 20 | Role of a doxorubi- cin-containing regimen in relapsed and resistant lymphomas: an 8-year follow-up study of EPOCH 显示文摘 | Gutierrez M Chabner BA Pearson D | 2000 | J CIin Oncol2000，18，21： | 1 |
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