|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gut microbiota imbalance and colorectal cancer显示文摘The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies. | Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 76 |
| 2 | Role of bacteria in the etiopathogenesis of inflammatory bowel disease显示文摘Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases,Crohn's disease(CD)and ulcerative colitis(UC).A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is suspected.In CD patients,with increased ileal expression of the CEACAM6 molecule acting as a receptor recognized by type 1 pilus bacterial adhesin,and with the identification of mutations in the NOD2-encoding gene,the presence of pathogenic invasive bacteria could be the link between abnormal ileal bacterial colonization and innate immune responses to invasive bacteria.In a susceptible host,the sequential etiological steps of the disease induced by adherent-invasive E.coli(AIEC)are:(1)abnormal colonization via binding to the CEACAM6 receptor,which is overexpressed in the ileal mucosa of CD patients;(2)ability to adhere to and to invade intestinal epithelial cells,which allows bacteria to cross the mucosal barrier;(3)survival and replication within infected macrophages in the lamina propria;and(4)induction of tumor necrosis factor-α secretion and granuloma formation. | Nicolas Barnich Arlette Darfeuille-Michaud | 2007 | World Journal of Gastroenterology2007，13，42： | 15 |
| 3 | Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging显示文摘AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided tools to better understand hostpathogen interactions at the early stage of disease, such as inflammatory bowel disease and colorectal cancer. | Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet | 2016 | World Journal of Clinical Oncology2016，7，3： | 10 |
| 4 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 5 | ViBe : a universal background subtraction algorithm for video sequences显示文摘 | BARNICH O VAN DROOGENBROECK M | 2011 | IEEE Transactions on Image Processing2011，20，6： | 1 |
| 6 | ViBe: a universal background subtraction algorithm for video sequences 显示文摘 | BARNICH O van DROOGENBROECK M | 2011 | IEEE Transactions on Image Processing2011，20，6： | 1 |
| 7 | ViBe:a universal back- ground subtraction algorithm for video sequences显示文摘 | Barnich O Van Droogenbroeck M | 2011 | IEEE Transactions on Image Proceeding2011，20，6： | 1 |
| 8 | Vibe:A universal background subtraction algotithm for video sequences 显示文摘 | Barnich O Droogenbroeck M V | 2011 | IEEE Transac- tions on Image Pr~essing2011，20，6： | 1 |
| 9 | Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death 显示文摘 | Glasser A L Boudeau J Barnich N | 2001 | Infection and Immunity2001，69，9： | 1 |
| 10 | ViBe:a universal background subtraction algorithm for video sequences 显示文摘 | Barnich O Vanogenbroeck M | 2011 | IEEE Transactions on Image Processing2011，20，6： | 1 |
| 11 | Crohn's disease adherent- invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing hu- man CEACAM 显示文摘 | Carvalho F A Barnich N Sivignon A | 2009 | The Journal of experimental medicine2009，206，10： | 1 |
| 12 | Vibe:A universal background subtraction algorightm for video sequences显示文摘 | BARNICH O DROOGENBROECK M V | | 0，，06： | 1 |
| 13 | GRIM-19 interacts with NOD2 and serves as down stream effector of anti-bacterial function in intestinal epithelial cells 显示文摘 | Barnich N Hisamatsu T Aguirre JE | 2005 | J Biol Chem2005，280，19： | 1 |
| 14 | ViBe: a universal back- ground subtraction algorithm for video sequences 显示文摘 | BARNICH O van DROOGENBROECK M | 2011 | IEEE Trans- actions on Image Processing2011，20，6： | 1 |
| 15 | ViBe: A universal back- ground subtraction algorithm for video sequences 显示文摘 | Barnich O Van Droogenbroeck M | 2011 | IEEETransactions on Image Processing2011，20，6： | 1 |
| 16 | ViBe: A Universal Background Subtraction Algorithm for Video Sequences显示文摘 | Olivier Barnich Marc Van Droogenbroeck | 2011 | IEEE Transactions on Image Processing2011，20，6： | 1 |
| 17 | ViBe:A universal background subtraction algorithm for video sequences显示文摘 | Olivier Barnich Marc Van Droogenbroeck | 2011 | IEEE:Transactions on Image Processing2011，20，6： | 1 |
| 18 | ViBe:a universal background subtraction algorithm for video sequences 显示文摘 | Barnich O Van Droogenbroeck M | 2011 | IEEE Transac- tions on Image Processing2011，20，6： | 1 |
| 19 | Vi Be:A universal background subtraction algorithm for video sequences显示文摘 | BARNICH O DROOGENBROECK M V | 2011 | IEEE Transactions on Image Processing2011，20，6： | 1 |
| 20 | ViBe: a universal back- ground subtraction algorithm for video sequences 显示文摘 | Barnich O van Droogenbroeck M | 2011 | IEEE Transactions on Image Processing2011，20，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员