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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Potential chlorinated and brominated interferences on the polybrominated diphenyl ether determinations by gas chromatography-mass spectrometry显示文摘 | ELJARRAT E de LA CAL A BARCELO D | 2003 | J Chromatogr A2003，1008，： | 1 |
| 3 | Priority lists for persistent organic pollutants and emerging contaminants based on their relative toxic potency in environmental samples显示文摘 | ELJARRAT E BARCELO D | 2003 | Trends in Analytical Chemistry2003，22，10： | 1 |
| 4 | Potential chlorinated and brominated interferences on the polybrominated diphenyl ether determinations by gas chromatography-mass spectrometry 显示文摘 | Eljarrat E De la Cal A Barcelo D | 2003 | Journal of Chromatography A2003，1008，2： | 1 |
| 5 | Computational results from a new Lagrangean relaxation algorithm for the capacitated plant location problem显示文摘 | Barcelo J Fernandez E Jomsten K | 1991 | European Journal of Operational Research1991，53，1： | 1 |
| 6 | Simuhaneous determination of hexabromocyclododecane, tetrabromobisphenol A, and related compounds in sewage sludge and sediment samples from Ebro River basin (Spain) 显示文摘 | Guerra P Eljarrat E Barcelo D | 2010 | Anal Bioanal Chem2010，397，7： | 1 |
| 7 | Familial progressive sensorineural deafness is mainly due to the mtDNA A1555G mutation and is enhanced by reatment of aminoglycosides显示文摘 | Estivill X Govea N Barcelo E | 1998 | Am Hum Genet1998，6227，： | 1 |
| 8 | Comparative analysis of the spindle and chromosome configurations of in vitro-matured oocytes from patients with endometriosis and from control subjects: a pilot study显示文摘 | BARCELOS I D VIEIRA R C FERREIRA E M MARTINS W P FERRIANI R A NAVARRO P A | 2009 | Fertil Steril2009，92，： | 1 |
| 9 | A well-balanced and adap- tive variational model for removal of mixed noise显示文摘 | BARCELOS C BARCELOS E | 2014 | Com- puters and electrical engineering2014，40，7： | 1 |
| 10 | In Vitro Fertilization using Non-sexed and Sexed Bovine Sperm: Sperm Concentration, Sorter Pressure, and Bull Effects显示文摘 | Barcelo'-Fimbres M Campos-Chillo'n LF Seidel G E | 2010 | Reproduction in Domestic Animals2010，46，6： | 1 |
| 11 | Short term response of the coccolithophore emiliania huxleyi to an abrupt change in seawater carbon dioxide concentrations显示文摘 | Barcelos e Ramos J Müller M N Riebesell U | 2010 | Biogeosciences2010，7，： | 1 |
| 12 | Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi显示文摘 | Ana Carolina Alves de Paula e Silva Caroline Barcelos Costa-Orlandi Fernanda Patrícia Gullo Fernanda Sangalli-Leite Haroldo Cesar de Oliveira Julhiany de Fátima da Silva Liliana Scorzoni Nayla de Souza Pitangui Suélen Andrea Rossi Tatiane Benaducci Vaness | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 13 | Familial progressive sensorineural deafness is mainly due to the mtDNA A1555G mutation and is enhanced by treatment of aminoglycosides显示文摘 | Estivill X Govea N Barcelo E | 1998 | Am J Hum Genet1998，62，： | 1 |
| 14 | Enantiomerie specific determination of hexabromoeyelododecane by liquid chromatography- quadrupole linear ion trap mass speetremetry in sediment samples显示文摘 | GUERRA P ELJARRAT E BARCELO D | 2008 | Journal of Chromatography A2008，1203，1： | 1 |
| 15 | Growth retardation in the early developing rat exposed to continuous hypobaric hypoxia显示文摘 | ALIPPI R M BARCELO A C RIO M E | 1983 | Acta Physiol Lat Am1983，33，1： | 1 |
| 16 | Simultaneous determination of hexabromocyclododecane, tetrabromobisphenol A, and related compounds in sewage sludge and sediment samples from Ebro River Basin (Spain) 显示文摘 | GUERRA P ELJARRAT E BARCELO D | 2010 | Analytical and Bioanalytieal Chemistry2010，397，7： | 1 |
| 17 | Mandibular growth retardation in growing rats chronically exposed to hypobaria显示文摘 | BOZZINI C E ALIPPI R M BARCELO A C | 1987 | J Dent Res1987，66，1： | 1 |
| 18 | Degradation Study of Benomyl and Carbendazim in Water by Liquid Chromatography and Multivariate Curvere Solution Methods显示文摘 | MALLAT E BARCELO D TAULER R | 1997 | Chromatographia1997，46，78： | 1 |
| 19 | Plasinogen activator inhibitor-1 (PAI-1) polymorphisms in patients with obstructive sleep apnea显示文摘 | BARCELO A LLOMPART E BARBE F | 2002 | Respir Med2002，96，： | 1 |
| 20 | How to measure uncertainties in environmental risk assessment显示文摘 | Darbra R M Eljarrat E Barcelo D | 2008 | Trends in Analytical Chemistry2008，，2： | 1 |
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