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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Localization of zinc and cadmium in Thlaspi caerulescens (Brassicaceae), a metallophyte that can hyperaccumulate both metals 显示文摘 | Vazquez M D Barcelo J Poschenrieder C | 1992 | J Plant Physiol1992，140，： | 1 |
| 3 | Trace ele- ment behaviour at the root-soil interface: Implications in phytoremediation显示文摘 | KIDD P BARCELO J BERNAL M P | 2009 | Eviron Exp Bot2009，67，： | 1 |
| 4 | Identification and determination of metabolites and degradation products of sulfonamide antibiotics显示文摘 | Garcia-Galan Jesus M Diaz-Cruz Silvia M Barcelo Damia | 2008 | Trends in Analytical Chemistry2008，27，11： | 1 |
| 5 | Chromium(VI) induced structural changes in bush bean plants显示文摘 | Vazques M D Poschenrieder C H Barcelo J | 1987 | Ann Bot1987，59，： | 1 |
| 6 | Determination of anionic and nonionicsurfactants,their degradation Products,and endocrine-dis-rupting compounds in sewage sludge by liquid chromatogra-phy/mass spectrometry显示文摘 | Petrovic M Barcelo D | 2000 | Anal Chem2000，72，19： | 1 |
| 7 | Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases显示文摘 | Barcelo Batllori S Andre M Servis C | 2002 | Proteomics2002，2，5： | 1 |
| 8 | Use of solid-phase extraction in various of its modalities for sample preparation in the determination of estrogens and progestogens in sediment and water显示文摘 | Lopezde Alda M J Barcelo D | 2001 | Journal of Chromatography2001，938，12： | 1 |
| 9 | Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor 显示文摘 | Radjenovic J Petrovic M Barcelo D | 2007 | Analytical and Bioanalytical Chemistry2007，387，4： | 1 |
| 10 | Frequencies of defective CYP2C19 alleles in a Hong Kong Chinese population 显示文摘 | Garcia- Barcelo M Chow LY Kum Chiu HF | 1999 | Clinical Chemistry1999，45，12： | 1 |
| 11 | Multi-residue method for trace level determination of pharmaceuticals in solid samples using pressurized liquid extraction followed by liquid chromatography/quadrupole-linear ion trap mass spectrometry显示文摘 | JELIC A PETROVIC M BARCELO D | 2009 | Talanta2009，80，1： | 1 |
| 12 | Determination oforganophosphorous pesticides in water by SPE followed by LC/ high flow pneumatically assisted electrospray MS显示文摘 | Molina C Honing M Barcelo D | 1994 | Anal Chem1994，66，24： | 1 |
| 13 | Environmental Behavior and Analysis of Veterinary and Human Drugs in Soils,Sediments and Sludge显示文摘 | DIAZ-CRUZ M S LOPEZ DE ALDA M J BARCELO D | 2003 | Trends in Analytical Chemistry2003，22，6： | 1 |
| 14 | Nuevos contaminantes organics(emergentes) in Cataluna显示文摘 | Lopez M J Petrovic M Barcelo D | 2003 | Reviews Analytical Chemistry2003，465，3： | 1 |
| 15 | Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment 显示文摘 | Radjenovic J Petrovic M Barcelo D | 2009 | Water Research2009，43，： | 1 |
| 16 | Drugs of abuse and their metabolites in the Ebro River basin : occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation显示文摘 | POSTIGO C DE ALDA M J L BARCELO D | 2010 | Environ Pollut2010，36，1： | 1 |
| 17 | Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human derived HepG2 cells显示文摘 | Serpeloni J M Barcelos G R Friedmann Angeli J P | 2012 | Toxicology in Vitro2012，26，2： | 1 |
| 18 | Removal of a broad range of surfactants from municipal wastewater-comparison between membrane bioreactor and conventional activated sludge treatment显示文摘 | Gonzalez S Petrovie M Barcelo D | 2007 | Chemosphere2007，67，2： | 1 |
| 19 | Peripheral Blood Mononuclear Cells Immunophenotyping in Pulmonary Tuberculosis Patients before and after Treatment显示文摘 | Warly Barcelos Olindo Assis Martins‐Filho Tania Mara Pinto Dabés Guimar?es Márcio Hamilton Prostzner Oliveira Silvana Spíndola‐de‐Miranda Beatriz Nascimento Carvalho Vicente de Paulo Coelho Peixoto Toledo | 2006 | Microbiology and Immunology2006，，： | 1 |
| 20 | Strengths and limitations of immunoassays for effective and efficient use for pesticide analysis in water samples: a review显示文摘 | HENNION M C BARCELO D | 1998 | Analytica Chimica Acta1998，362，： | 1 |
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