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| 1 | Contrast-enhanced ultrasonography in the evaluation of incidental focal liver lesions: A cost-effectiveness analysis显示文摘AIM To determine whether contrast-enhanced ultrasonography(CEUS) as the first-line method is more costeffective in evaluating incidentally discovered focal liver lesions(FLLs) than is computed tomography(CT) and magnetic resonance imaging(MRI). METHODS Between 2010 and 2015, our prospective study enrolled 459 patients with incidentally found FLLs. The biological nature of FLLs was assessed by CEUS in all patients. CT or MRI examinations were added in unclear cases. The sensitivity and specificity of CEUS were calculated. The total costs of CEUS examinations and of the added examinations performed in inconclusive cases were calculated. Afterwards, the theoretical expenses for evaluating incidentally discovered FLLs using CT or MRI as the first-line method were calculated. The resultswere compared. RESULTS The total cost of the diagnostic process using CEUS for all enrolled patients with FLLs was 75884 USD. When the expenses for additional CT and MRI examinations performed in inconclusive cases were added, the total cost was 90540 US dollar(USD). If all patients had been examined by CT or MR as the first-line method, the costs would have been 78897 USD or 384235 USD, respectively. The difference between the cost of CT and CEUS was 3013 USD(4%) and that between MRI and CEUS was 308352 USD(406.3%). We correctly described 97.06% of benign or malignant lesions, with 96.99% sensitivity and 97.09% specificity. Positive predictive value was 94.16% and negative predictive value was 98.52%. In cases with 4 and more lesions, malignancy is significantly more frequent and inconclusive findings significantly less frequent(P < 0.001).CONCLUSION While the costs of CEUS and CT in evaluating FLLs are comparable, CEUS examination is far more costeffective in comparison to MRI. | Miriama Smajerova Hana Petrasova Jirina Little Petra Ovesna Tomas Andrasina Vlastimil Valek Eva Nemcova Barbora Miklosova | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 2 | Natural orifice transluminal endoscopic surgeryvs laparoscopic ovariectomy:Complications and inflammatory response显示文摘AIM:To compare natural orifice transluminal endoscopic surgery (NOTES) vs standard laparoscopic ovariectomy in mini pigs with respect to technical aspects,complications and parameters of systemic inflammatory response.METHODS:This was a randomized,experimental,survival study.Ten female mini pigs underwent NOTES transgastric ovariectomy (NOTES group) and ten female mini pigs underwent laparoscopic ovariectomy (LAP group).A 'percutaneous endoscopic gastrostomy' approach with guidewire and sphincterotome was used for gastrotomy creation.The ovary was resected using standard biopsy forceps and a snare.The access site was closed using a 'KING' closure with a single endoloop and several clips.In the laparoscopic group,a three-port laparoscopy and an ovariectomy were performed with the use of standard laparoscopic devices.C-reactive protein (CRP),white blood count and interleukin (IL)-6 plasma levels were used as indicators of systemic inflammatory response.All animals were euthanized 28 d after surgery.RESULTS:All animals survived without complications.The mean procedure time was 41.3 min ± 17.6 min (NOTES group) and 25.7 min ± 5.25 min (LAP group,P < 0.02).Postmortem examinations demonstrated that 50% and 70% of animals were free of any complications in the NOTES and LAP groups,respectively.The remaining animals developed minor complications (adhesions) in a comparable frequency between the two groups.In the NOTES group,one animal developed a small intramural gastric abscess close to the gastrotomy site.A minor serous exudate that was present in 50% and 40% of the animals in the NOTES and laparoscopy groups,respectively,was not considered a complication.In both groups CRP levels increased significantly on the 2nd and 7th postoperative days (POD) and returned to normal after 28 d.On POD 2,an increase of CRP level was significantly higher in the NOTES group compared to the LAP group.Values of IL-6 did not differ from baseline values in either of the groups postoperatively.Interestingly,the platelet count decreased significantly on POD 2,but returned close to baseline values on POD 7 and PODs 28-30.CONCLUSION:Both NOTES and laparoscopic ovariectomies had a similar frequency of minor complications.However,the NOTES technique produced an increased systemic inflammatory response on POD 2. | Jan Martínek Ondej Ryska Tereza Filípková Radek Dolezel Stefan Juhas Jan Motlík Monika Holubová Vladimír Nosek Barbora Rotnáglová Miroslav Zavoral Miroslav Ryska | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 3 | Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?显示文摘Systematic inflammatory response after spinal cord injury(SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate(EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses(curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses(curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days. Rats were evaluated using behavioral tests(the Basso, Beattie, and Bresnahan(BBB) open-field locomotor test, flat beam test). Spinal cord tissue was analyzed using histological methods(Luxol Blue-cresyl violet staining) and immunohistochemistry(anti-glial fibrillary acidic protein, anti-growth associated protein 43). Cytokine levels(interleukin-1β, interleukin-4, interleukin-2, interleukin-6, macrophage inflammatory protein 1-alpha, and RANTES) were measured using Luminex assay. Quantitative polymerase chain reaction was performed to determine the relative expression of genes(Sort1, Fgf2, Irf5, Mrc1, Olig2, Casp3, Gap43, Gfap, Vegf, NfκB, Cntf) related to regenerative processes in injured spinal cord. We found that all treatments displayed significant behavioral recovery, with no obvious synergistic effect after combined therapy of curcumin and ECGC. Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1β, interleukin-4 and interleukin-6 cytokines. These results imply that although the expected synergistic response of this combined therapy was less obvious, aspects of tissue regeneration and immune responses in severe SCI were evident. | Jiri Ruzicka Lucia Machova Urdzikova Barbora Svobodova Anubhav G. Amin Kristyna Karova Jana Dubisova Kristyna Zaviskova Sarka Kubinova Meic Schmidt Meena Jhanwar-Uniyal Pavla Jendelova | 2018 | Neural Regeneration Research2018，13，1： | 4 |
| 4 | Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway显示文摘Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats(GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed. | Barbora Filova Maria Malinova Janka Babickova Lubomira Tothova Daniela Ostatnikova Peter Celec Julius Hodosy | 2015 | Neuroscience Bulletin2015，31，3： | 3 |
| 5 | Longitudinal molecular characterization of endoscopic specimens from colorectal lesions显示文摘AIM: To compare molecular profiles of proximal colon, distal colon and rectum in large adenomas, early and late carcinomas. To assess feasibility of testing directed at molecular markers from this study in routine clinical practice. METHODS: A prospective 3-year study has resulted in the acquisition of samples from 159 large adenomas and 138 carcinomas along with associated clinical parameters including localization, grade and histological type for adenomas and localization and stage for carcinomas. A complex molecular phenotyping has been performed using multiplex ligation-dependent probe amplification technique for the evaluation of Cp G-islandmethylator phenotype(CIMP), PCR fragment analysis for detection of microsatellite instability and denaturing capillary electrophoresis for sensitive detection of somatic mutations in KRAS, BRAF, TP53 and APC genes.RESULTS: Molecular types according to previously introduced Jass classification have been evaluated for large adenomas and early and late carcinomas. An increase in CIMP+ type, eventually accompanied with KRAS mutations, was notable between large adenomas and early carcinomas. As expected, the longitudinal observations revealed a correlation of the CIMP+/BRAF + type with proximal location. CONCLUSION: Prospective molecular classification of tissue specimens is feasible in routine endoscopy practice. Increased frequency of some molecular types corresponds to the developmental stages of colorectal tumors. As expected, a clear distinction is notable for tumors located in proximal colon supposedly arising from the serrated(methylation) pathway. | Petra Minarikova Lucie Benesova Tereza Halkova Barbora Belsanova Stepan Suchanek Jiri Cyrany Inna Tuckova Jan Bures Miroslav Zavoral Marek Minarik | 2016 | World Journal of Gastroenterology2016，22，20： | 2 |
| 6 | 为什么不避而不去的危险呢?大鼠在岛上生存的塞老鼠的意外行为显示文摘亩cypriaeus是最近发现的一种特有物种进化的大约一半在一百万年前在塞浦路斯的土地在大多数哺乳动物的掠食者和竞争者的缺席。像在其他地中海岛屿,区系成分的共生和国内全新世人类后殖民入侵物种急剧变化。我们研究了挖掘塞鼠标行为上的反应,这些新的竞争对手的气味(黑色和挪威鼠,家鼠和多刺的鼠标)和捕食者(猫)以及对照组(中药领域的小鼠,豚鼠)。我们与叙利亚不同的共存历史的老鼠来自大陆的人口进行比较。令人惊讶的是,塞老鼠未能避免其目前主要的竞争对手,黑老鼠的气味。此外,塞人和叙利亚家老鼠的反应模式的研究气味源出现相当媲美。有一个明显的趋势是更喜欢在无味的木屑其他鼠类的气味以及避免家猫的气味。总之,无论从长期隔离的食肉动物也用黑色的大鼠的影响小鼠eompetitory和antipredatory反应从根本上[当前生态61近期的强势竞争(4):781-791,2015 ]。 | Daniel FRYNT Margareta BALADOVA Barbora ELIASOVA Silvie LISKOVA Eva LANDOVA | 2015 | Current Zoology2015，61，4： | 2 |
| 7 | Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells-a clue to stem cell-based therapy显示文摘Retinal degenerative disorders,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration or glaucoma,represent the most common causes of loss of vision and blindness.In spite of intensive research,treatment options to prevent,stop or cure these diseases are limited.Newer therapeutic approaches are offered by stem cell-based therapy.To date,various types of stem cells have been evaluated in a range of models.Among them,mesenchymal stem/stromal cells(MSCs)derived from bone marrow or adipose tissue and used as autologous cells have been proposed to have the potential to attenuate the negative manifestations of retinal diseases.MSCs delivered to the vicinity of the diseased retina can exert local anti-inflammatory and repairpromoting/regenerative effects on retinal cells.However,MSCs also produce numerous factors that could have negative impacts on retinal regeneration.The secretory activity of MSCs is strongly influenced by the cytokine environment.Therefore,the interactions among the molecules produced by the diseased retina,cytokines secreted by inflammatory cells and factors produced by MSCs will decide the development and propagation of retinal diseases.Here we discuss the interactions among cytokines and other factors in the environment of the diseased retina treated by MSCs,and we present results supporting immunoregulatory and trophic roles of molecules secreted in the vicinity of the retina during MSC-based therapy. | Vladimir Holan Barbora Hermankova Magdalena Krulova Alena Zajicova | 2019 | World Journal of Stem Cells2019，11，11： | 2 |
| 8 | Nutrient Enrichment in Tropical Wetlands:Shifts from Autotrophic to Heterotrophic Nitrogen Fixation显示文摘 | HanaˇS Eliˇska R Barbora P | 2010 | Biogeochemistry2010，，101： | 1 |
| 9 | Effect of the talc filler content on the mechanical properties of polypropylene composites 显示文摘 | Lubomir L J Pavlina J Barbora L | 2008 | Journal of Applied Polymer Science2008，110，5： | 1 |
| 10 | High temperature oxidation of titanium-silicon alloys显示文摘 | Dalibor V Barbora B Tomos K | 2003 | Materials Science and Engineering A2003，361，12： | 1 |
| 11 | The interleukin-6(-174)G/C promoter polymorphism in associated with type 2 diabetes mellitus in Native Americans and Caucasians显示文摘 | Barbora Vozarova Jose-Manuel Fernandez-RealWilliam C | 2003 | Hum GENET2003，112，： | 1 |
| 12 | The interleukin-6(174) G/C promoter polymorphism in associated with type 2 diabetes mellitus in native americans and caucasians显示文摘 | BARBORA V JOSE M FERNANDEZ-REALWILLIAM C | 2003 | Hum Genet2003，112，： | 1 |
| 13 | Wash-dry cycle induced changes in low-ordered parts of regenerated cellulosic fibers 显示文摘 | SIROKA Barbora MANIAN Avinash P NOISTERNING Michael F | 2012 | Journal of Applied Polymer Science2012，，1： | 1 |
| 14 | ,Chiral Aspects of Metabolism of Antiinflammatory Drug Flobufen in Human Hepatocytes显示文摘 | LENKA SKALOVA RADIM KRA L BARBORA SZOTAKOVA | 2003 | CHIRALITY2003，15，8： | 1 |
| 15 | The emer- ging role of chronic low-grade inflammation in the pathophysiology of polycystic ovary syndrome 显示文摘 | Soulmaz Shorakae Barbora de Courten Honnma H | 2015 | Semin Reprod Med2015，33，4： | 1 |
| 16 | Modified alaminosilicates as low-cost sorbents of As ( Ⅲ ) from anoxic groundwater 显示文摘 | Barbora D Lucie F Grygar T | 2009 | J Hazard Mater2009，165，13： | 1 |
| 17 | Neodymium triflate modi- fied nation composite membrane for reduced alcohol per- meability in direct alcohol fuel cell显示文摘 | Shroti N Barbora L Verma A | 2011 | International Jour- nal of Hydrogen Energy2011，36，14： | 1 |
| 18 | Low plasma adiponectin concentrations do not predict weight gain in humans显示文摘 | Barbora V Norbort S Robert S | 2002 | Diabetes2002，51，10： | 1 |
| 19 | High - performance liquid chromatography study of stereospecific microsomal erizymes catalyzing the reduction of a potential cytostatic drug, oracin Interspecies comparison显示文摘 | Vladimir Wsol Barbora Szotakova Eva Kvasnickova | 1998 | Chromatography A1998，797，： | 1 |
| 20 | Pulmonary surfactant:phase behavior and function显示文摘 | Barbora P Vincent S Stephen BH | 2002 | Curr Opin Struct Biol2002，12，： | 1 |
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