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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Viscous drag reduction using stream wise-aligned riblet 显示文摘 | Vukoslayceic P Wallace J M Balint J L | 1992 | AIAA Journal (S0001-1452)1992，30，4： | 1 |
| 4 | Viscous Drag Reduction Using Stream Wise-Aligned Riblet 显示文摘 | Vukoslayceic P Wallace J M Balint J L | 1992 | AIAA Journal1992，30，4： | 1 |
| 5 | Investigation of deformation and failure features in hot stamping of AA6082: Experimentation and modelling显示文摘 | MOHAMED M S FOSTER A D LIN J BALINT D S DEAN T A | 2012 | International Journal of Machine Tools and Manufacture2012，53，1： | 1 |
| 6 | Effects of a low dose estrogen-antiandrogen combination(Diane-35)on clinical signs of and- rogenization, hormone profile and ovarian size in patients with polycystic ovary syndrome显示文摘 | Prelevic G M Wurzburger M I Balint P L | 1989 | Ggnecol Endocrinol1989，13，： | 1 |
| 7 | Activation of Notchl signaling is required for beta-catenin-mediated human primary melanoma progression 显示文摘 | Balint K Xiao M Pinnix CC | 2005 | J Clin Invest2005，115，11： | 1 |
| 8 | Neuromuscular control of aerodynamic forces and moments in the blowfly, callifora vicina 显示文摘 | Balint C N Dickinson M H | 2004 | The Jourmal of Experimental Biology2004，207，22： | 1 |
| 9 | Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression显示文摘 | Balint K Xiao M Pinnix CC | | 0，，11： | 1 |
| 10 | Musculoskele-tal ultrasound including definitions for ultrasonographicpathology显示文摘 | Wakefield RJ Balint PV Szkudlarek M | 2005 | J Rheumatol2005，32，12： | 1 |
| 11 | Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein显示文摘 | Larrick JW Hirata M Balint RF | 1995 | Infect Immun1995，63，： | 1 |
| 12 | Musculoskeletal ultra- sound including definitions for ultrasonographic pathology 显示文摘 | Wakefield RJ Balint PV Szkudlarek M | 2005 | J Rheumatol2005，32，： | 1 |
| 13 | Activation of Notchl signaling is required for beta - catenin - mediated human primary melanoma progression 显示文摘 | Balint K Xiao M Pinnix CC | 2005 | J Clin Invest2005，115，11： | 1 |
| 14 | Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein显示文摘 | Hirata M Balint RF | 1995 | Infect Immun1995，63，3： | 1 |
| 15 | Detection of mycoplasma bovis with an improved pcrassay显示文摘 | Tenk M Balint A Stipkovits L | 2006 | Acta Veterinaria Hungarica2006，54，4： | 1 |
| 16 | Model based optimization of some growth process parameters of a Nd:YVO4 cylindrical bar grown by edge-defined film-fed growth (EFG) method in the presence of the pressure显示文摘 | BRAESCU L BALINT A M SZABO R | 2006 | Opt Mater2006，28，： | 1 |
| 17 | A control procedure for the shape of a Nd:YAG and Nd:YVO4 cylindrical bar grown by edge-defined film-fed growth method under oscillated furnace pressure显示文摘 | BALINT A M BRAESCU L SZABO R | 2006 | Opt Mater2006，28，： | 1 |
| 18 | Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein 显示文摘 | Larrick J W Hirata M Balint R F | 1995 | Infect Immun1995，63，4： | 1 |
| 19 | Activation of Notch 1 signaling is required for beta - catenin - mediated human primary melanoma progression 显示文摘 | Balint K Xiao M Pinnix CC | 2005 | J Clin Invest2005，115，： | 1 |
| 20 | Viscous drag reduction using streamwise-aligned riblets显示文摘 | Wallace J M Balint J L | 1992 | AIAA Journal1992，30，4： | 1 |
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