|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | Gangliosides activate Trk receptors by inducing the release of neurotrophins显示文摘 | Rabin SJ Bachis A Mocchetti I | 2002 | J Biol Chem2002，277，49： | 1 |
| 3 | Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates 显示文摘 | Lange BM Bachi A Wilm M | 2000 | EMBO J2000，19，： | 1 |
| 4 | A short history of LIM domains (1993-2002):from protein interaction to degradation显示文摘 | Retaux S Bachy I | 2002 | Mol Neurobiol2002，26，23： | 1 |
| 5 | Standard Distance Measmes And Related Methods For Spalial Analysis 显示文摘 | Bachi R | 1962 | Papers of Ttle Regional Sci- ence Association1962，，10： | 1 |
| 6 | Gangliosides prevent excitotoxicity through activation of Trk B receptor显示文摘 | Bachis A Rabin SJ Del Fiacco M | 2002 | Neurotox Res2002，4，： | 1 |
| 7 | The ehemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gp120 neurotoxicity in cerebellar granule cells显示文摘 | Bachis A Mocchetti I | 2004 | J Neurosci Res2004，75，1： | 1 |
| 8 | Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases显示文摘 | Acquas E Bachis A Nosheny RL | 2004 | Neurotox Res2004，5，8： | 1 |
| 9 | Proteomic analysis of grapevine resis- tance induced by Trichoderma harzianum T39 reveals specific de- fence pathways activated against Downy Mildew显示文摘 | PALMIERI M C PERAZZOLLI M MATAFORA V MORETTO M BACHI A PERTOT I | 2012 | Journal of Ex- perimental Botany2012，63，17： | 1 |
| 10 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation:a report from the French Society of Bone Marrow and Cellular Therapy显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，5： | 1 |
| 11 | Gangliosidesprevent excitotoxicity through activation of Trk B receptor 显示文摘 | Bachis A Rabin SJ Del Fiacco M | 2002 | Neurotox Res2002，4，： | 1 |
| 12 | Quantitative proteomics as a new piece of the systems biology puzzle显示文摘 | Bachi A Bonaldi T | 2008 | Joumal of Proteomics2008，71，3： | 1 |
| 13 | Ganglioside prevent excitoxicity through activation of TrkB receptor显示文摘 | Bachis A Robin SJ Del Fiacco M | 2002 | Neurotox Res2002，4，3： | 1 |
| 14 | The impact of immunosuppressive drugs on the analysis of T cell activation显示文摘 | Rovira P Mascarell L Truffa Bachi P | 2000 | Curr Med Chem2000，7，： | 1 |
| 15 | Gangliosides prevent excitotoxicity through activation of TrkB receptor显示文摘 | Bachis A Rabin SJ Del Fiaceo M | 2002 | Neurotox Res2002，4，3： | 1 |
| 16 | Free radical and grape seed proanthocy anidin extract:importance in human health and disease prevention显示文摘 | Debasis Bagchi Manashi Bachi Sidney J Stohs | 2000 | Toxicology2000，148，： | 1 |
| 17 | Chemokine receptors and neurotrophie factors : Potential therapy against AIDS dementia显示文摘 | Mocchetti I Bachis A Masliah E | 2008 | J Neurosci Res2008，86，2： | 1 |
| 18 | Enantioselective total synthesis of (-)-α-Kainic acid显示文摘 | Bachi M D Melman A | 1998 | Pure and applied chemistry1998，70，： | 1 |
| 19 | Gangliosides activate Trk receptors by inducing the release of neurotrophins显示文摘 | Rabin SJ Bachis A Mocchetti | 2002 | Biol Chem2002，277，49： | 1 |
| 20 | Stereoselective synthesis of (±)-α-Kainic acid using free radical key reactions显示文摘 | Bachi M D Bar-Ner N Melman A | 1996 | The Journal of Organic Chemistry1996，61，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员