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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | 基于潜在分类模型的农田生态补偿标准测算——一个离散选择实验模型的实证显示文摘确立科学合理的生态标准是建立和提高社会主义生态文明的关键。本文对当前我国运用选择实验法对农田生态补偿标准估算多假设受访者同质性偏好的现状,运用潜在分类模型(Latent Class Model,LCM)研究武汉市不同类别特征的市民对农田生态服务价值的保有意愿情况,并进一步运用Gold Latent软件测算基于市民支付意愿的武汉市农田生态补偿标准。研究发现:193.5%的武汉市受访市民愿意为保有和改善农田生态系统的服务功能进行一定额度的农田生态补偿标准支付,但仍有部分比例的受访者对农田生态服务价值的全面认知还不够(如空气质量)。2武汉市不同受访市民对农田生态属性的偏好存在异质性,93%的受访市民属于正常偏好型。另有7%的受访市民属于空气质量偏好型。受访者的收入水平、对农田生态服务价值的意识程度和是否愿意进行一定额度的农田生态补偿支付三个变量是影响其类别归属的决定性因素。3正常偏好型和空气质量偏好型市民对于农田生态补偿的支付意愿分别为6 888.74元/hm^2和518.50元/hm^2,计算得到基于武汉市市民平均支付意愿的农田生态补偿标准为7 407.24元/hm^2。研究结果不仅可以为武汉市农田保护制定出更具针对性和合理的农田生态补偿标准提供初步的科学依据,还可以为农田生态补偿筹集到除了中央政府财政转移之外的来自于农田生态服务受益者的资金支付。 | 杨欣 Michael Burton 张安录 | 2016 | 中国人口·资源与环境2016，26，7： | 22 |
| 3 | The interaction of versican with its binding partners显示文摘Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within theextracellular matrix (ECM). Versican, like other members of its family, has unique N- and C-terminal globular regions,each with multiple motifs. A large glycosaminoglycan-binding region lies between them. This review will begin byoutlining these structures, in the context of ECM proteoglycans. The diverse binding partners afforded to versican byvirtue of its modular design will then be examined. These include ECM components, such as hyaluronan, type Icollagen, tenascin-R, fibulin-1, and -2, fibrillin-1, fibronectin, P- and L-selectins, and chemokines. Versican also binds tothe cell surface proteins CD44, integrin β1, epidermal growth factor receptor, and P-selectin glycoprotein ligand-1.These multiple interactors play important roles in cell behaviour, and the roles of versican in modulating such processesare discussed. | Yao Jiong WU David P. LA PIERRE Jin WU Albert J. YEE Burton B. YANG | 2005 | Cell Research2005，15，7： | 13 |
| 4 | Friend or foe: the role of microRNA in chemotherapy resistance显示文摘 | Haoran LI Burton B YANG | 2013 | Acta Pharmacologica Sinica2013，34，7： | 12 |
| 5 | 麦夸里岛毛皮海豹体内小塑料颗粒的来源和生物聚集显示文摘本文研究了从麦夸里岛上毛皮海豹(Arctocephalus spp.)粪便中发现的164个塑料颗粒(平均长度为4.1mm)。其中41个塑料颗粒的电子显微照片显示,从其形状来看,没有一个可被确定为塑料颗粒原料——通常这样的颗粒是圆柱形和球形的。而海豹粪便中的164个塑料颗粒全都是7种颜色的角形颗粒(原料颗粒通常是透明的或白色的),并可被分为两类:①沿晶体线碎裂的和可能是紫外线分解的;②被磨蚀成带有圆角的不规则形状(擦痕明显可见)。白色、棕色、绿色、黄色以及蓝色是最常见的颜色。在成分上,它们来自于5种聚合物群:聚乙烯93%;聚丙烯4%;多(1-CI-1-聚丁二烯)聚氯丁二烯2%;三聚氰胺-尿素(酚)(甲醛)树脂0.5%以及纤维素(绳纤维)0.5%。较大的群是漂浮的,比重小于海水。这些小塑料是由较大颗粒(碎片)分解而成的。它们看来是被水冲上岸的并在卵石海滩上受到研磨的塑料用品分解而成的。大多数颗粒(70%)肯定是由于经过不断的磨蚀而最后形成今天的形状。据假设,塑料颗粒被冲到海洋中,然后按其大小有选择地被一种中上层鱼——Electrona subaspera——吃掉,而这种鱼后来又被毛皮海豹吃掉。因此,这些塑料颗粒是由这种鱼和海豹在其正常的摄食过程中聚集的。 | Cecilia Eriksson Harry Burton 林宝法 | 2003 | AMBIO-人类环境杂志2003，32，6： | 7 |
| 6 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 7 | 子痫前期:病理生理学和临床意义显示文摘子痫前期是一种常见疾病,尤其影响首次妊娠。其临床表现多样,但通常表现为高血压和蛋白尿。这些全身症状是由于在合体滋养细胞的压力作用下,胎盘释放了可溶性因子。子痫前期主要有早发型和迟发型2种亚型,其他几种亚型目前尚未确定。早发型子痫前期是由于胎盘缺陷而出现,而迟发型子痫前期可能是由于胎盘的正常衰老,以及母体对心血管和代谢疾病的遗传易感性交互产生。子痫前期因胎盘和母体因素产生的原因因人而异。最近的研究主要集中在早孕期的胎盘-子宫相互作用。本文旨在对关于子痫前期的预测、预防和治疗方法的最新文献进行归纳综述。 | Graham J Burton Christopher W Redman James M Roberts Ashley Moffett 秦萌(译) 金滢 潘凌亚(校 | 2019 | 英国医学杂志中文版2019，22，11： | 6 |
| 8 | Arterial vs venous blood gas differences during hemorrhagic shock显示文摘AIM: To characterize differences of arterial(ABG) and venous(VBG) blood gas analysis in a rabbit model of hemorrhagic shock. METHODS: Following baseline arterial and venous blood gas analysis, fifty anesthetized, ventilated New Zealand white rabbits were hemorrhaged to and maintained at a mean arterial pressure of 40 mm Hg until a state of shock was obtained, as defined by arterial p H ≤ 7.2 and base deficit ≤-15 mmol/L. Simultaneous ABG and VBG were obtained at 3 minute intervals. Comparisons of p H, base deficit, p CO2, and arteriovenous(a-v) differences were then made between ABG and VBG at baseline and shock states. Statistical analysis was applied where appropriate with a significance of P < 0.05. RESULTS: All 50 animals were hemorrhaged to shockstatus and euthanized; no unexpected loss occurred. Significant differences were noted between baseline and shock states in blood gases for the following parameters: p H was significantly decreased in both arterial(7.39 ± 0.12 to 7.14 ± 0.18) and venous blood gases(7.35 ± 0.15 to 6.98 ± 0.26, P < 0.05), base deficit was significantly increased for arterial(-0.9 ± 3.9 m Eq/L vs-17.8 ± 2.2 m Eq/L) and venous blood gasses(-0.8 ± 3.8 m Eq/L vs-15.3 ± 4.1 m Eq/L, P < 0.05). p CO2 trends(baseline to shock) demonstrated a decrease in arterial blood(40.0 ± 9.1 mm Hg vs 28.9 ± 7.1 mm Hg) but an increase in venous blood(46.0 ± 10.1 mm Hg vs 62.8 ± 15.3 mm Hg), although these trends were non-significant. For calculated arteriovenous differences between baseline and shock states, only the p CO2 difference was shown to be significant during shock.CONCLUSION: In this rabbit model, significant differences exist in blood gas measurements for arterial and venous blood after hemorrhagic shock. A widened p CO2 a-v difference during hemorrhage, reflective of poor tissue oxygenation, may be a better indicator of impending shock. | Kristopher Burton Williams Ashley Britton Christmas Brant Todd Heniford Ronald Fong Sing Joseph Messick | 2014 | World Journal of Critical Care Medicine2014，3，2： | 6 |
| 9 | Parenting preschoolers with autism: Socioeconomic influences on wellbeing and sense of competence显示文摘BACKGROUND Previous research suggests that parents raising a child with autism experience higher levels of psychological distress than parents of typically developing children and parents of children with other developmental disorders. Little is known, however, about the intersection between the effects of socioeconomic status(SES) on the wellbeing and sense of parental competency of parents of preschoolers with autism and how it relates to child symptom severity.AIM To examine the relationship between their child's symptom severity, SES, as measured by neighbourhood advantage and occupational status, on the psychological wellbeing and perceived parenting competence among parents of preschoolers with autism.METHODS Parents of 117 preschool-aged children with a diagnosis of autism spectrum disorder(ASD), 107 mothers and 54 fathers, completed questionnaires about their child's symptoms of ASD and functioning, their own perceptions of their wellbeing and parental competence on entry to an early intervention program in Sydney, Australia. Parents also provided demographic information pertaining to their occupation, level of education attained and address(postcode). All children were also assessed for their severity of symptoms using the Autism Diagnostic Observation Schedule. The Australian Socioeconomic Index of occupationalstatus as a measure of familial SES and the Index of Relative Socio-economic Advantage and Disadvantage as a measure of neighbourhood advantage were used to examine the impact of SES on parental sense of competence and wellbeing.RESULTS Compared to normative populations, both mothers and fathers in our sample reported significantly higher levels of parenting sense of efficacy but lower levels of interest in the parenting role. Mothers also displayed higher levels of satisfaction. Both mothers and fathers displayed higher levels of depression than normative populations with mothers also reporting greater levels of stress and anxiety. Child symptom severity was associated with maternal parenting competency with these relationships amplified among mothers with higher familial SES and who lived in areas of greater neighbourhood advantage.Increased adaptive functioning was associated with better maternal wellbeing,particularly among mothers who lived in areas of greater neighbourhood advantage. Contrastingly, paternal parenting competence was generally not influenced by child adaptive functioning or symptom severity, although for those in higher familial SES brackets, children's symptom severity and maladaptive symptoms were negatively related to paternal sense of parenting efficacy. There was a trend towards moderate relationships between lower familial SES and greater depression, stress and anxiety among fathers, but no relationship with their child's ASD symptom severity or functioning.CONCLUSION SES differentially impacts wellbeing and sense of parenting competence and its relationship to the impact of child symptoms for mothers and fathers of preschoolers with autism. | Nisha E Mathew Karen L O Burton Anne Schierbeek Rudi ?rn?ec Amelia Walter Valsamma Eapen | 2019 | World Journal of Psychiatry2019，9，2： | 6 |
| 10 | (1,3;1,4)-β-D-Glucans in Cell Walls of the Poaceae, Lower Plants, and Fungi: A Tale of Two Linkages显示文摘( 1,3 ; 1,4 )-- D-Glucans 由 unbranched 和 unsubstituted 链组成( 1,3 )-并且( 1,4 )-- glucosyl 残余,在哪个比率( 1,4 )-- D-glucosyl 残余到( 1,3 )-- D-glucosyl 残余看起来影响多糖并且因此的不仅物理化学的性质它在房间墙中的功能的性质,而且它由不同植物种类的采纳在进化期间。( 1,3 ; 1,4 )-- D-glucans 作为在 Poaceae 的细胞墙中的非有纤维质的矩阵阶段多糖广泛地分布式,它最近相对演变并且由草和商业地重要的谷物组成种,而是他们不太通常在更低的脉管的植物被发现例如马尾,在水藻并且在真菌。(1,3; 1,4 )-- D-glucans 经常被认为主要房间墙主要是部件,但是最近的观察显示他们能也位于某些纸巾的第二等的墙。涉及 depolymerisation 的酶(1,3; 1,4 )-- D-glucans 很好被描绘了。相反,在净化为负责的酶的起始的困难( 1,3 ; 1,4 )-- D-glucan 生合成在编码的基因的鉴定减缓了进步( 1,3 ; 1,4 )-- D-glucan synthases ,但是新兴的比较 genomics 和联系技术允许贡献的基因的至少一些( 1,3 ; 1,4 )--在要鉴别的 Poaceae 的 D-glucan 合成。类似的基因和酶是否也调停(1,3; 1,4 )-- 在更低的植物和真菌的 D-glucan 生合成还没被知道。这里,我们比较不同好结构(1,3; 1,4 )-- 越过植物王国的 D-glucans,最近在他们的生合成被含有,并且考虑房间生物学的方面的基因的现在的当前的信息(1,3; 1,4 )-- 在 Poaceae 的 D-glucan 生合成。 | Rachel A. Burton Geoffrey B. Fincher | 2009 | Molecular Plant2009，2，5： | 5 |
| 11 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 12 | Targeting circular RNAs as a therapeutic approach: current strategies and challenges显示文摘Significant progress has been made in circular RNA(circRNA)research in recent years.Increasing evidence suggests that circRNAs play important roles in many cellular processes,and their dysregulation is implicated in the pathogenesis of various diseases.CircRNAs are highly stable and usually expressed in a tissue-or cell type-specific manner.Therefore,they are currently being explored as potential therapeutic targets.Gain-of-function and loss-of-function approaches are typically performed using circRNA expression plasmids and RNA interference-based strategies,respectively.These strategies have limitations that can be mitigated using nanoparticle and exosome delivery systems.Furthermore,recent developments show that the cre-lox system can be used to knockdown circRNAs in a cell-specific manner.While still in the early stages of development,the CRISPR/Cas13 system has shown promise in knocking down circRNAs with high specificity and efficiency.In this review,we describe circRNA properties and functions and highlight their significance in disease.We summarize strategies that can be used to overexpress or knockdown circRNAs as a therapeutic approach.Lastly,we discuss major challenges and propose future directions for the development of circRNA-based therapeutics. | Alina T.He Jinglei Liu Feiya Li Burton B.Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 13 | NATURAL PRODUCTIVITY OF ACRYLIC ACID AND DIMETHYL SULPHIDE DURING A SUMMER BLOOM OF PHAEOCYSTIS POUCHETII IN ANTARCTIC COASTAL WATER显示文摘Water samples were collected over P. pouchelii bloom period beginning in November 1988, in 15m water column, from 10km offshore of Davis Station, Vestfold Hill, Antarctica. The concentrations of acrylic acid and dimethyl sulphide (DMS), which are toxic compounds in the water samples, were determined by HPLC and GC. The result shows that the concentration of acrylic acid varies in 0.001-0.510vmol·L-1 and the concentration of DMS in 0.003-0.588 mol·L-1 during P. pouchetii bloom. Both the increased since late December 1988 and reached the highest concentration in early January 1989, then they decreased rapidly and returned to lower level from middle January to February in agreement with variation in cell number of the unicell alga P. pouchetii. The correlation coefficients between acrylic acid and P. pouchetii and between DMS and P. pouchetii are all 0.998. It is undoubted that P. pouchetii produced acrylic acid and DMS. The highest productivity of acrylic acid and DMS were 9.76×10-8 | Andrew Davidson Harry Burton | 1992 | Chinese Journal of Polar Science1992，3，1： | 5 |
| 14 | Testing Unconstrained Optimization Software显示文摘 | Jorge J. Moré Burton S. Garbow Kenneth E. Hillstrom | 1981 | ACM Transactions on Mathematical Software (TOMS)1981，，1： | 4 |
| 15 | 亚致死浓度噻虫嗪对西方蜜蜂免疫相关基因表达的影响显示文摘【目的】新烟碱类农药是目前全球应用最广泛的一类农药,大量研究表明亚致死量新烟碱类农药能够影响蜜蜂的采集、学习和记忆等行为。本文主要探究亚致死浓度新烟碱类农药噻虫嗪对西方蜜蜂5种免疫相关基因:Abaecin类抗菌肽(ABA)、Hymenoptaecin类抗菌肽(HYM)、防御素(Defensin,DEF)、葡萄糖脱氢酶(Glucose dehydrogenase,GLD)和溶解酵素(Lysozyme,LYS)表达及蜜蜂个体生存的影响。【方法】(1)通过饲喂管法确定噻虫嗪对蜜蜂的经口性急性毒性;(2)对蜜蜂长期(10 d)饲喂亚致死浓度(100、10、2.2μg·kg^(-1)噻虫嗪,然后运用荧光定量PCR技术检测了蜜蜂免疫相关基因的表达变化,并统计各组蜜蜂的存活率。【结果】(1)噻虫嗪对蜜蜂经口性半数致死浓度LC_(50)=692μg·kg^(-1);(2)亚致死浓度噻虫嗪对ABA、DEF和LYS表达没有显著影响;但能够极显著的降低HYM表达水平(P<0.01);100μg·kg^(-1)噻虫嗉处理能显著增加蜜蜂GLD表达(P<0.05)。【结论】研究表明亚致死浓度噻虫嗪能够抑制蜜蜂免疫相关基因HYM表达,这对于从分子水平上探究新烟碱类农药对蜜蜂健康和生存的影响具有一定的生物学意义。 | 施腾飞 王宇飞 Sawyer Burton 齐磊 余林生 | 2017 | 应用昆虫学报2017，54，4： | 4 |
| 16 | Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis显示文摘AIM:To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer(CC)or high grade dysplasia(HGD).METHODS:This is a single center(Lenox Hill Hospital)retrospective cohort and descriptive study of extensive ulcerative colitis(UC)for 20 years or more with a minimum of 3 surveillance colonoscopies and biopsies performed after the first 10 years of UC diagnosis.Data analyzed included:duration of UC,date of diagnosis of(CC)or(HGD),number of surveillance colonoscopies,and biopsies showing histological inflammation and its severity in each of 6 segments when endoscopic appearance is normal.Two subgroups of patients were compared:group 1 patients who developed CC/HGD and group 2 patients who did not develop CC/HGD.RESULTS:Of 115 patients with longstanding UC reviewed,68 patients met the inclusion criteria.Twenty patients were in group 1 and 48 in group 2.We identified the number of times for each patient when the endoscopic appearance was normal but biopsies nevertheless showed inflammation.Overall,histological disease activity in the absence of gross/endoscopic disease was found in 31.2%(95%CI:28%-35%)of colonoscopies performed on the entire cohort of 68 patients.Histological disease activity when the colonoscopy showed an absence of gross disease activity was more common in group 1 than group 2 patients,88%(95%CI:72%-97%)vs 59%(95%CI:53%-64%).Only 3/20(15%)of patients in group 1 ever had a colonoscopy completely without demonstrated disease activity(i.e.,no endoscopic or histological activity)as compared to 37/48(77%)of patients in group 2,and only 3.3%(95%CI:0.09%-8.3%)of colonoscopies in group 1 had no histological inflammation compared to23%(95%CI:20%-27%)in group 2.CONCLUSION:Progression to HGD or CC in extensive ulcerative colitis of long standing was more frequently encountered among those patients who demonstrate persistent histological inflammation in the absence of gross mucosal disease.Our findings support including the elimination of histological inflammation in the definition of mucosal healing,and support this endpoint as an appropriate goal of therapy because of its risk of increasing dysplasia and colon cancer. | Burton I Korelitz Keith Sultan Megha Kothari Leo Arapos Judy Schneider Georgia Panagopoulos | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 17 | En bloc resection for locally advanced cancer of the pancreas: Is it worthwhile?显示文摘 | Aaron R. Sasson M.D. John P. Hoffman M.D. Eric A. Ross Ph.D. Steven A. Kagan James F. Pingpank M.D. Burton L. Eisenberg M.D | 2002 | Journal of Gastrointestinal Surgery2002，，2： | 4 |
| 18 | Choice of laxatives and colonoscopic preparation in pregnant patients from the viewpoint of obstetricians and gastroenterologists显示文摘AIM: To elucidate the preferences of gastroenterologists at our institution and compare them to those of obstetricians when making decisions in the pregnant patient, including which type of bowel preparations to use for ? exible sigmoidoscopy or colonoscopy, as well as which laxatives can be used safely. METHODS: Surveys were mailed to all attending gastroenterologists (n = 53) and obstetricians (n = 99) at our institution. Each survey consisted of the 14 most common laxative or motility agents used in pregnancy and inquired about the physician’s prescribing habits in the past as well as their willingness to prescribe each medication in the future. The survey also listed four common bowel preparations used prior to colonoscopy and sigmoidoscopy and asked the physician to rank the order of the preferred agent in each case. RESULTS: With regard to common laxatives, both gastroenterologists and obstetricians favor the use of Metamucil, Colace, and Citrucel. Both groups appear to refrain from using Fleets Phosphosoda and Castor oil. Of note, obstetricians are less inclined to use PEG solution and Miralax, which is not the case with gastroenterologists. In terms of comparing bowel preparations for colonoscopy, 50% of gastroenterologists prefer to use PEG solution and 50% avoid the use of Fleets Phosphosoda. Obstetricians seem to prefer Fleets Phosphosoda (20%) and tend to avoid the use of PEG solution (26%). With regard to bowel preparation for sigmoidoscopy, both groups prefer Fleets enema the most (51%), while magnesium citrate is used least often (38%). CONCLUSION: It is clear that preferences in the use ofbowel cleansing preparations between the two groups exist, but there have not been many case controlled human studies in the pregnant patient that give clear cut indications for using one versus another drug. In light of the challenge of performing controlled trials in pregnant women, more extensive surveys should be undertaken to gather a larger amount of data on physicians’ experiences and individual preferences. | Jeevan Vinod Jennifer Bonheur Burton I Korelitz Georgia Panagopoulos | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 19 | Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity显示文摘Recent studies have shown that global translational reprogramming is an early activation event in pattern-triggered immunity,when plants recognize microbe-associated molecular patterns.However,it is not fully known whether translational regulation also occurs in subsequent immune responses,such as effector-triggered immunity(ETI).In this study,we performed genome-wide ribosome profiling in Arabidopsis upon RPS2-mediated ETI activation and discovered that specific groups of genes were translationally regulated,mostly in coordination with transcription.These genes encode enzymes involved in aromatic amino acid,phenylpropanoid,camalexin,and sphingolipid metabolism.The functional significance of these components in ETI was confirmed by genetic and biochemical analyses.Our findings provide new insights into diverse translational regulation of plant immune responses and demonstrate that translational coordination of metabolic gene expression is an important strategy for ETI. | Heejin Yoo George H.Greene Meng Yuan Guoyong Xu Derek Burton Lijing Liu Jorge Marques Xinnian Dong | 2020 | Molecular Plant2020，13，1： | 4 |
| 20 | Abnormalities of uterine cervix in women with inflammatory bowel disease显示文摘AIM: To evaluate the prevalence of abnormalities of the uterine cervix in women with inflammatory bowel disease (IBD) when compared to healthy controls. METHODS: One hundred and sixteen patients with IBD [64 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC)] were matched to 116 healthy controls by age (+/- 2 years) at the time of most recent papanicolaou (Pap) smear. Data collected consisted of age, race, marital status, number of pregnancies, abortions/miscarriages, duration and severity of IBD, Pap smear results within five years of enrollment, and treatment with immunosuppressive drugs. Pap smear results were categorized as normal or abnormal including atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LGSIL), and high-grade squamous intraepithelial lesion (HGSIL). RESULTS: The median age at the time of Pap smear was 46 (range: 17-74) years for the IBD group and matched controls (range: 19-72 years). There were more Caucasian subjects than other ethnicities in the IBD patient group (P = 0.025), as well as fewer abortions (P = 0.008), but there was no significant difference regarding marital status. Eighteen percent of IBD patients had abnormal Pap smears compared to 5% of controls (P = 0.004). Subgroup analysis of the IBD patients revealed no significant differences between CD and UC patients in age, ethnicity, marital status, number of abortions, disease severity, family history of IBD, or disease duration. No significant difference was observedin the number of abnormal Pap smears or the use of immunosuppressive medications between CD and UC patients (P = 0.793). No definitive observation could be made regarding HPV status, as this was not routinely investigated during the timeframe of our study. CONCLUSION: Diagnosis of IBD in women is related to an increased risk of abnormal Pap smear, while type of IBD and exposure to immunosuppressive medications are not. This has significant implications for women with IBD in that Pap smear screening protocols should be conscientiously followed, with appropriate investigation of abnormal results. | Jyoti Bhatia Jason Bratcher Burton Korelitz Katherine Vakher Shlomo Mannor Maria Shevchuk Gworgia Panagopoulos Adam Ofer Ecaterina Tamas Panayota Kotsali Oana Vele | 2006 | World Journal of Gastroenterology2006，12，38： | 3 |
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