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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	The reactions between Ca-based solids and gases representative of those found in a fluidized-bed incinerator显示文摘	LAWRENCE A D BU J	2000	Chemical Engineering Science2000，55，24：	2
3	Insulin receptor substrate 2 plays important roles in 17beta-estradiol-induced bone formation 显示文摘	BU YH PENG D ZHOU HD	2009	J Endocrinol Invest2009，32，8：	1
4	Topological structure analysis of the protein-protein interaction network in budding yeast 显示文摘	Bu D Zhao Y Cai L	2003	Nucleic Acids Research2003，31，9：	1
5	In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow显示文摘	Hu H Wang J Bu D	2009	PLOS ONE2009，4，11：	1
6	Localization of MV-algebras and lu-groups显示文摘	Bu§neag D Piciu D	2003	Algebra univers2003，50，：	1
7	Castleman's tumours and production of autoantibody in paraneoplastic pemphigus 显示文摘	Wang L Bu D Yang Y	2004	Lancet2004，363，：	1
8	Distributed access control with priva-cy support in wireless sensor networks 显示文摘	HE D BU J ZHU S	2011	IEEE Transactions onWireless Communications2011，10，10：	1
9	The effects of mulching on maize growth, yield and water use in a semi-arid region显示文摘	Bu L D Liu J L Zhu L	2013	Agricultural Water Management2013，123，：	1
10	A note on the formulas for the Drazin inverse of the sum of two matrices显示文摘	Bu C J Zhang C D	2013	Linear Algebra and its Appl2013，439，3：	1
11	Monolithic mesoporous silica templated by microemulsion liquid crystals 显示文摘	Feng P Y Bu X H Galen D	2000	Journal of American Chemical Society2000，122，5：	1
12	Lanthanum-substituted Bismuth Titanate for Use in Non-volatile Memorise显示文摘	Kang B S Bu S D	1999	Nature1999，401，：	1
13	In vitro culture and characteriza- tion of a mammary eplthelial cell line from Chinese Holstein dair ycow显示文摘	Hu H Wang J Bu D	2009	PLoS One2009，4，11：	1
14	Host-guest symmetry and charge matching in two germanates with intersecting three-dimen- sional channels显示文摘	BU X 'FENG P STUCKY G D	2000	Chem Mater2000，12，：	1
15	Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy 显示文摘	Jia WW Bu X Philips D	2004	Can J Physiol Pharmacol2004，82，：	1
16	Lanthanum- Substituted Bismuth Titanate for Use in Non-Volatile Memories显示文摘	PARK B H KANG B S BU S D	1999	Nature1999，401，：	1
17	Lanthanum-Substituted Bismuth Titanate for Use in Nonvolatile Memories 显示文摘	Park B H Kang B S Bu S D	1999	Nature (London)1999，401，：	1
18	Castleman's tumours and production of autoantibody in paraneoplastic pemphigus 显示文摘	Wang L Bu D Yang Y	2004	Lancet2004，363，9408：	1
19	Intragraft cytokine expression and tolerance induction in rat renal allografts 显示文摘	Saagi BM Fisher RA Bu D	1999	Transplantation1999，67，4：	1
20	Lanthanum - substituted bismuth titanate for use in non - volatile memories显示文摘	Park B H Kang B S Bu S D	1999	Nature1999，401，：	1

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